DRSC/TRiP Functional Genomics Resources

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Protein Alignment Zfp36l1 and Tis11

DIOPT Version :9

Sequence 1:NP_031590.1 Gene:Zfp36l1 / 12192 MGIID:107946 Length:338 Species:Mus musculus
Sequence 2:NP_001259490.1 Gene:Tis11 / 32222 FlyBaseID:FBgn0011837 Length:436 Species:Drosophila melanogaster


Alignment Length:400 Identity:128/400 - (32%)
Similarity:181/400 - (45%) Gaps:89/400 - (22%)


- Green bases have known domain annotations that are detailed below.


Mouse    11 FDLSEVLCKGNKMLNYSTPSAGGCLLDRKAVGTP--AGGGFPRRHSVTLPSSKFHQNQLLSSLKG 73
            ||.:||. |..:||     .|.|..||::....|  ..||..|  :::.|:....|.|.....:.
  Fly    36 FDCNEVR-KEIRML-----LAHGANLDQQHQQQPHRHHGGLTR--TISQPAQLIQQQQQQHQQQQ 92

Mouse    74 EPAPSLSSRDSRFRDRSFSEGGERLLPTQKQPGSGQ--VNSSRYKTELCRPFEENGACKYGDKCQ 136
            :..|:::|..:...:........:|..||.:|...|  :|:|||||||||||||.|.||||:|||
  Fly    93 QQQPAVASLVTITENLGNMNLHRKLERTQSEPLPPQQPMNTSRYKTELCRPFEEAGECKYGEKCQ 157

Mouse   137 FAHGIHELRSLTRHPKYKTELCRTFHTIGFCPYGPRCHFIHNAEERRA-----LAGGRDLSADRP 196
            ||||.||||::.||||||||.|||||::|||||||||||:|||:|.||     .|.....|..:.
  Fly   158 FAHGSHELRNVHRHPKYKTEYCRTFHSVGFCPYGPRCHFVHNADEARAQQAAQAAKSSTQSQSQS 222

Mouse   197 RLQHSFSFAGFPSAAATAAATGLLDSPTS---------------------ITPPPILSADDLLGS 240
            :...|.:|:...:.::..::.....|.:|                     ::||..:|......|
  Fly   223 QQSSSQNFSPKSNQSSNQSSNSSSSSSSSGGGGGGGNSINNNNGSQFYLPLSPPLSMSTGSDRES 287

Mouse   241 PT-----LPDGTNNPFAF----------------SSQELASLFAPSMGL---------------- 268
            ||     .|..:...|.|                :|...::..|..|||                
  Fly   288 PTGSLSLSPTNSLTSFPFHDALQHGYLASNGAKSNSSASSTSSASGMGLGMSMGIGQGMIIGQGL 352

Mouse   269 -PGGGSPTTFLFRPMSESPHMFDSP---PSPQDSLSDHEGYLSSSSSS-----HSGSDSPTLDNS 324
             .|...|.|     ..|||::..||   |.|.|.:....|..::|..|     .|.|.....:::
  Fly   353 GMGHHGPAT-----PPESPNVPISPVHTPPPYDVVVSGSGAGNNSVGSKQLLQKSVSTPMQQEDT 412

Mouse   325 RRLPIFSRLS 334
            .|||:|:|||
  Fly   413 PRLPVFNRLS 422

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Zfp36l1NP_031590.1 Necessary and sufficient for the association with mRNA decay enzymes and mRNA decay activation. /evidence=ECO:0000250|UniProtKB:Q07352 1..111 25/103 (24%)
Tis11B_N 3..99 CDD:309616 20/89 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 71..113 8/43 (19%)
zf-CCCH <115..>177 CDD:325094 51/61 (84%)
Necessary for mRNA decay activation. /evidence=ECO:0000250|UniProtKB:Q07352 185..338 42/216 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 273..338 21/69 (30%)
Tis11NP_001259490.1 zf-CCCH 136..161 CDD:279036 21/24 (88%)
zf-CCCH 174..198 CDD:279036 20/23 (87%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 61 1.000 Domainoid score I10408
eggNOG 1 0.900 - - E1_COG5063
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 158 1.000 Inparanoid score I4247
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0000616
OrthoInspector 1 1.000 - - oto93285
orthoMCL 1 0.900 - - OOG6_101179
Panther 1 1.100 - - LDO PTHR12547
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2078
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1110.850

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