DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Brca1 and nopo

DIOPT Version :9

Sequence 1:	NP_033894.3	Gene:	Brca1 / 12189	MGIID:	104537	Length:	1812	Species:	Mus musculus
Sequence 2:	NP_611305.1	Gene:	nopo / 37083	FlyBaseID:	FBgn0034314	Length:	435	Species:	Drosophila melanogaster

Alignment Length:	461	Identity:	91/461 - (19%)
Similarity:	159/461 - (34%)	Gaps:	124/461 - (26%)

- Green bases have known domain annotations that are detailed below.

Mouse    22 LECPICLELI---KEPVSTKCDHIFCKFCMLKLLNQKKGPSQCPLCKNEITKRSLQGSTRFSQLA 83
            |.|.||.||.   .|..:|.|.|:|...|:.:.|::.|   .||.|:|:.|.|::  ...:..||
  Fly     4 LNCVICAELFGQADEVFATVCGHMFHHNCLNQWLDRSK---TCPQCRNKCTTRNI--FRVYFNLA 63

Mouse    84 EELLRIMAAFELDTGM---QLTNGF----SFSKKRNNSCERLNE----EASIIQSV-GYRNRVRR 136
            .     :....:|.|.   ||.|..    ...|:||...:::.:    :...:::: |...:|::
  Fly    64 N-----LDVSHIDVGSLQEQLDNAMLSMKMVEKERNKDEQQIRDLKETQKKCLKTIAGLEQKVQK 123

Mouse   137 LPQVEPGNATLKD--------SLGVQLSNLGIVRSVKKNRQTQPRK------KSVYIELDSDSSE 187
                       ||        .:||..|:..:|..::|..:|...:      .|..:...|..::
  Fly   124 -----------KDFLISSYVEQIGVLKSDAHVVDGLRKENKTLKSQIQSMEGISAILAAGSADAD 177

Mouse   188 ETVTKPGD-----------------CSVRDQELLQTAPQEAGDEGKLHSAEEAACEFSEGIRNIE 235
            ..:....|                 |..:..||.........|   |....|...:..|.:.::|
  Fly   178 RLLKNEADPHVLANWVSTLKRELRQCESKKTELRNVVKVVQND---LRKEIELKRKLEERVSHLE 239

Mouse   236 H--HQCSDDLNPTENHATERHPEKCQSISISNVCVEPCGTDAHASSLQPE----TSSLLLIED-- 292
            .  :|..:.|...||        |...:...|.   .||.:::..:|:.|    |.|..:.|:
  Fly   240 SDLYQAQEKLQAFEN--------KTAYLDSPNA---SCGLNSNILALKREERRTTISPTVKENIK 293

Mouse   293 RMNAEKAEFCN-KSKQPGIAVSQQSRWAASKGTCNDRQVPSTGEKVGPNADSLSDREKWTHPQSL 356
            |:....:.:.| ||...|:|....::  .:.|....:..|..|  ||......|...:.|
  Fly   294 RIEESTSPYLNIKSSSVGLAHLLNTK--GNIGLAKSKISPIKG--VGGGVSMTSGTIRKT----- 349

Mouse   357 CPENSGATTDVPWITLNSSVQKVNEWFSRTGEMLTSDSASARRHESNAEAAVVLEVSNEVDGGFS 421
                            :|.:.:....|.:...:|.|.|:||....:.         ||.|..|..
  Fly   350 ----------------SSDLSEKYSIFKKPRLLLGSSSSSALTATTG---------SNFVYNGMG 389

Mouse   422 SSRKTD 427
            .|.|.|
  Fly   390 GSEKVD 395

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Brca1	NP_033894.3	rad18	15..>172	CDD:273165	40/172 (23%)
		RING-HC_BRCA1	18..65	CDD:319412	16/45 (36%)
		RING-HC finger (C3HC4-type)	24..64	CDD:319412	15/42 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..198		6/55 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	321..362		7/40 (18%)
		BRCT_assoc	342..503	CDD:372330	16/86 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	492..581
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	640..767
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	864..899
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	947..995
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1030..1056
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1147..1185
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1205..1230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1244..1289
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1313..1343
		Interaction with PALB2. /evidence=ECO:0000250	1353..1380
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1437..1547
		BRCT_BRCA1_rpt1	1593..1689	CDD:349367
		BRCT_BRCA1_rpt2	1700..1797	CDD:349353
nopo	NP_611305.1	zf-RING_2	5..47	CDD:290367	15/44 (34%)
nopo	NP_611305.1	zf-rbx1	<5..47	CDD:289448	15/44 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3349
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.030