Protein Alignment SPPL3 and SppL

DIOPT Version :10

• Sequence 1: XP_054227100.1
• Gene: SPPL3 / 121665
• HGNCID: 30424
• Length: 403
• Species: Homo sapiens
• Sequence 2: NP_001163740.1
• Gene: SppL / 43128
• FlyBaseID: FBgn0039381
• Length: 422
• Species: Drosophila melanogaster
• Alignment Length: 389
• Identity: 252/389 - (64%)
• Similarity: 311/389 - (79%)
• Gaps: 22/389 - (5%)

Human    30 SLVDSSQVSTFLISILLIVYGSFRSLNMDFENQDKE--KDSNSSSGSFNGNS---------TNNS 83
            |::|||:|||.|||:||||||||||||::.|.:::|  |.:.|.:....|..         |.:.
  Fly    41 SVMDSSRVSTCLISMLLIVYGSFRSLNIEQEAREREQKKRNESMTNLLTGEPVEKEPNLYFTADK 105

Human    84 IQTIDSTQALFLPIGASVSLLVMFFFFDSVQVVFTICTAVLATIAFAFLLLPMCQYLTRPCSPQN 148
            ..|:|:..||.||:|||:|||:|||||||:|::|.:|||::||:|.||||||||||:.|||:...
  Fly   106 FATLDTMHALCLPLGASISLLIMFFFFDSMQLLFAVCTAIIATVALAFLLLPMCQYIIRPCTDGK 170

Human   149 KISFGCCGRFTAAELLSFSLSVMLVLIWVLTGHWLLMDALAMGLCVAMIAFVRLPSLKVSCLLLS 213
            :.|||.|||||||||.||:|||.:|.|||||||||||||:.||||||.||||||||||||.|||:
  Fly   171 RFSFGFCGRFTAAELFSFTLSVSIVCIWVLTGHWLLMDAMGMGLCVAFIAFVRLPSLKVSTLLLT 235

Human   214 GLLIYDVFWVFFSAYIFNSNVMVKVATQPADNPLDVLSRKLHLGPNVGRDVPRLSLPGKLVFPS- 277
            |||||||||||.|:|||::||||||||:|||||:.:::|||||| .:.||.|:|:|||||||||
  Fly   236 GLLIYDVFWVFLSSYIFSTNVMVKVATRPADNPVGIVARKLHLG-GIVRDTPKLNLPGKLVFPSL 299

Human   278 -STGSHFSMLGIGDIVMPGLLLCFVLRYDNYKKQ--ASGDSCGAPGPANISGRMQKVSYFHCTLI 339
             :|| ||||||:||:||||||||||||||.|||.  .:.|...:| |..:..|:   :||||:|:
  Fly   300 HNTG-HFSMLGLGDVVMPGLLLCFVLRYDAYKKAQGVTSDPTLSP-PRGVGSRL---TYFHCSLL 359

Human   340 GYFVGLLTATVASRIHRAAQPALLYLVPFTLLPLLTMAYLKGDLRRMWSEPFHSKSSSSRFLEV 403
            |||:|||||||:|.:.:||||||||||||||||||.||||||||||||||||.::..|.: |||
  Fly   360 GYFLGLLTATVSSEVFKAAQPALLYLVPFTLLPLLLMAYLKGDLRRMWSEPFIAQQPSKQ-LEV 422

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SPPL3	XP_054227100.1	Peptidase_A22B	80..393	CDD:282158	221/316 (70%)
SppL	NP_001163740.1	Peptidase_A22B	102..413	CDD:282158	221/316 (70%)