DRSC/TRiP Functional Genomics Resources

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Protein Alignment AEBP2 and YPR015C

DIOPT Version :10

Sequence 1:NP_001107648.1 Gene:AEBP2 / 121536 HGNCID:24051 Length:517 Species:Homo sapiens
Sequence 2:NP_015340.1 Gene:YPR015C / 856125 SGDID:S000006219 Length:247 Species:Saccharomyces cerevisiae


Alignment Length:202 Identity:49/202 - (24%)
Similarity:72/202 - (35%) Gaps:71/202 - (35%)


- Green bases have known domain annotations that are detailed below.


Human   206 SLEMSSDGEPLSRMDSEDSISSTIM-----------------DVDSTISSGRST----PAMMNGQ 249
            ||..:.|  |:.|......|.|.::                 .:.||.:|..:.    |:|.:.|
Yeast    74 SLHQTED--PVWRSSPNSIIFSPVIATPQPFPLTFVERQSCCPIYSTAASSYTAQSVPPSMQHFQ 136

Human   250 GSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVF------------------V 296
            .....:..|..|:                   :.::|: ||..|..                  |
Yeast   137 EENHRAVSNEQYS-------------------LPNVHI-GQNPGTLLSQTQTDLDLIQKQLRAVV 181

Human   297 CLWKGC----KVYNTPSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQQN 357
            .|.|.|    ||.:.|||    |:.|.|.|:||.||||....||.||..:..:.||:.||  |:.
Yeast   182 KLRKQCPICGKVCSRPST----LRTHYLIHTGDTPFKCTWEHCNKSFNVKSNMLRHLRTH--QKK 240

Human   358 SSKVSSQ 364
            .:|...|
Yeast   241 IAKKKHQ 247

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AEBP2NP_001107648.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..229 7/22 (32%)
Interaction with RBBP4 209..294 16/105 (15%)
COG5048 <215..>339 CDD:227381 37/166 (22%)
C2H2 Zn finger 266..286 CDD:275368 0/19 (0%)
C2H2 Zn finger 297..322 CDD:275368 11/28 (39%)
C2H2 Zn finger 330..352 CDD:275368 7/21 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 352..394 4/13 (31%)
Interaction with SUZ12. /evidence=ECO:0000269|PubMed:29499137 407..478
Important for nucleosome binding activity of the PRC2 complex. /evidence=ECO:0000269|PubMed:29499137 495..517
YPR015CNP_015340.1 COG5048 <17..247 CDD:227381 48/200 (24%)
C2H2 Zn finger 187..207 CDD:275370 9/23 (39%)
C2H2 Zn finger 215..237 CDD:275370 7/21 (33%)
Blue background indicates that the domain is not in the aligned region.

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