Protein Alignment AEBP2 and YGR067C

DIOPT Version :10

• Sequence 1: NP_001107648.1
• Gene: AEBP2 / 121536
• HGNCID: 24051
• Length: 517
• Species: Homo sapiens
• Sequence 2: NP_011581.4
• Gene: YGR067C / 852958
• SGDID: S000003299
• Length: 804
• Species: Saccharomyces cerevisiae
• Alignment Length: 217
• Identity: 40/217 - (18%)
• Similarity: 68/217 - (31%)
• Gaps: 95/217 - (43%)

Human   317 RHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPT------------------------------ 351
            ||..:|:|.|||:|.|  |..||..:..|.||:.|
Yeast    25 RHERSHAGVKPFQCQV--CKHSFVRRDLLQRHIRTVHRTFLLSSYASMTGDKADIPVSLGVGDVD 87

Human   352 --------------------------HFSQQNSSKVSSQPK---AKEESPSKAGMNKRRKLKNKR 387
                                      |:...|..|:..|.:   .||.|..|.|.::.:::|::.
Yeast    88 STSPRDIKMETLVNSMIKVNSGLINIHYHSSNVEKMDKQQRCVIGKESSSLKKGKSRFKQVKSRL 152

Human   388 RRSLPRPHDFFDAQTLDAIRHRAIC--FNLSAHIESLGKGHSVVFHSTVIAKRKEDSGKIKLLLH 450
            ..|:  ........:||.|..|.|.  |.       :|..|.|               :.|:..:
Yeast   153 ESSI--SVKILQEYSLDFISSRDILTFFR-------MGVSHLV---------------ENKIFQN 193

Human   451 WMP--------EDILPDVWVNE 464
            :.|        ::::...|:|:
Yeast   194 FFPDLFSSLQNDELVESFWINK 215

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AEBP2	NP_001107648.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..229
		Interaction with RBBP4	209..294
		COG5048	<215..>339	CDD:227381	10/21 (48%)
		C2H2 Zn finger	266..286	CDD:275368
		C2H2 Zn finger	297..322	CDD:275368	2/4 (50%)
		C2H2 Zn finger	330..352	CDD:275368	9/77 (12%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..394		11/44 (25%)
		Interaction with SUZ12. /evidence=ECO:0000269|PubMed:29499137	407..478		10/68 (15%)
		Important for nucleosome binding activity of the PRC2 complex. /evidence=ECO:0000269|PubMed:29499137	495..517
YGR067C	NP_011581.4	C2H2 Zn finger	10..30	CDD:275368	2/4 (50%)
		zf-C2H2	36..57	CDD:395048	9/22 (41%)
		C2H2 Zn finger	38..57	CDD:275368	8/20 (40%)