Protein Alignment AEBP2 and hsr1

DIOPT Version :10

• Sequence 1: NP_001107648.1
• Gene: AEBP2 / 121536
• HGNCID: 24051
• Length: 517
• Species: Homo sapiens
• Sequence 2: NP_593553.1
• Gene: hsr1 / 2543251
• PomBaseID: SPAC3H1.11
• Length: 582
• Species: Schizosaccharomyces pombe
• Alignment Length: 400
• Identity: 80/400 - (20%)
• Similarity: 118/400 - (29%)
• Gaps: 158/400 - (39%)

Human   125 LVGSSGGSSSDETRSLSPGAASSSSGDGDGKEGLEEPKGPRGSQGGGGGGSSSSSVVSSGGDEGY 189
            |..|||..|   |.|..|...|..|....|.....|.:....|..||...:|.:..........|
pombe   300 LTVSSGPLS---TASSIPSNCSCPSVKSSGPSYHAEQEVNVNSYNGGIPSTSYNDTPQQSVTGSY 361

Human   190 GTGGGGS-----SATSGGRRGSLE-------MSSDGEPLSRMDSEDSISSTIMDVDSTISSGRST 242
            .:|...|     :.|||....|:|       :.:||....|...:.|...|            |.
pombe   362 NSGETMSTYLNQTNTSGRSPNSMEATEQIGTIGTDGSMKRRKRRQPSNRKT------------SV 414

Human   243 PAMMNGQGSTTSSSKNIAYNCCWDQCQACFNSSPDLADHIRSIHVDGQRGGVFVCLWKGCKVYNT 307
            |....|:          ::.|  .:|...|..|..|..||||:
pombe   415 PRSPGGK----------SFVC--PECSKKFKRSEHLRRHIRSL---------------------- 445

Human   308 PSTSQSWLQRHMLTHSGDKPFKCVVGGCNASFASQGGLARHVPTHFSQ--------QNSSKVSS- 363
                          |:.:|||.|:   |...|:.:..|.:|...|.:.        |.|...||
pombe   446 --------------HTSEKPFVCI---CGKRFSRRDNLRQHERLHVNASPRLACFFQPSGYYSSG 493

Human   364 ------QPKAKEESPSKAGMNKRRKLKNKRRRSLPRPHDFFDAQTLDAIRHRAICFNLSAHIESL 422
                  ||:...|..:|..:|                      |.:|           |:.||:.
pombe   494 APGAPVQPQKPIEDLNKIPIN----------------------QGMD-----------SSQIENT 525

Human   423 GKGHSVVFHSTVIAKRKEDSGKIKLLLHWMPEDILPDVWVNESERHQLKTKVVHLSKLPKDTALL 487
                     :.:::.::..|.:|...:...|..|.|::                |||||..|
pombe   526 ---------NLMLSSQRPLSQQIVPEIAAYPNSIRPEL----------------LSKLPVQT--- 562

Human   488 LDPNIYRTMP 497
              ||  :.||
pombe   563 --PN--QKMP 568

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AEBP2	NP_001107648.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..229		28/115 (24%)
		Interaction with RBBP4	209..294		17/84 (20%)
		COG5048	<215..>339	CDD:227381	21/123 (17%)
		C2H2 Zn finger	266..286	CDD:275368	8/19 (42%)
		C2H2 Zn finger	297..322	CDD:275368	0/24 (0%)
		C2H2 Zn finger	330..352	CDD:275368	5/21 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	352..394		10/56 (18%)
		Interaction with SUZ12. /evidence=ECO:0000269|PubMed:29499137	407..478		8/70 (11%)
		Important for nucleosome binding activity of the PRC2 complex. /evidence=ECO:0000269|PubMed:29499137	495..517		1/2 (50%)
hsr1	NP_593553.1	COG5048	103..582	CDD:227381	79/399 (20%)
		C2H2 Zn finger	425..446	CDD:275368	9/58 (16%)
		C2H2 Zn finger	454..473	CDD:275368	5/21 (24%)