DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Bmp1 and Cubn

DIOPT Version :9

Sequence 1:NP_001346950.1 Gene:Bmp1 / 12153 MGIID:88176 Length:991 Species:Mus musculus
Sequence 2:NP_727348.2 Gene:Cubn / 326235 FlyBaseID:FBgn0052702 Length:3750 Species:Drosophila melanogaster


Alignment Length:865 Identity:205/865 - (23%)
Similarity:319/865 - (36%) Gaps:261/865 - (30%)


- Green bases have known domain annotations that are detailed below.


Mouse   326 ACGETLQDSTGNFSSPEYPNGYSAHMHCVWRISVTPGEKIILNFTSMDLYRSRL-------CWYD 383
            ||...|.:..|..:||.|||...:...|.:.||......|.|......|.....       |...
  Fly   852 ACDYKLNNEQGTITSPGYPNLTRSDRICTYTISTATNTVISLKRIDFQLTNGESDDDDNDECLTT 916

Mouse   384 YVEVRDGFWRKAPLRGRFCGGKLPEP-IVSTDSRLWVEFRSSSNWVGKGFFAVYEAI------CG 441
            .:.:.||..||  :.|.:||...||. .||..:.|.:...:..:.:|:||...|.|:      ||
  Fly   917 NLRINDGLNRK--ILGPYCGKNQPEENFVSETNYLQLHLSTDVDSMGRGFKFEYRALATGNDKCG 979

Mouse   442 GDVKKDNGHIQSPNYPDDYRPSKVCIWRIQVSEGFHVGLTFQSFEIERHDSCAYDYLEVRDG--- 503
            |...:...||:.|.:.|.|.....|.|.|.......:.|.:.||.:|....|.|||||:.|.   
  Fly   980 GVHTRSGDHIRLPVHDDSYAGEATCYWVIMAPANKAIRLHWNSFSLENAVDCIYDYLEIYDSLGA 1044

Mouse   504 --HSESSNLIGRYCGYEKPDDIKSTSSRLWLKFVSDGSINKAGFAVNF-FKEVDECSRPNRGGCE 565
              :.|.|..:.:|||...|:|:.|.|.:|.||||||.|.:..||.:.: |::             
  Fly  1045 QVNDERSKPLAKYCGNSVPEDLLSHSRQLVLKFVSDYSESDGGFDLTYTFED------------- 1096

Mouse   566 QRCLNTLGSYKCSCDPGYELAPDKRRCEAACGGFLTKLNGSITSPGWPKEYPPNKNCIWQLVAPT 630
                                       .|.|||.:...:|.:|||.:|..|....:|.|.|....
  Fly  1097 ---------------------------RAKCGGHIHASSGELTSPEYPANYSAGLDCDWHLTGTI 1134

Mouse   631 QYRISLQFDFFETEGNDVCKYDFVEVRSGLTADSKLHGKFCGSEKPEVITSQYNNMRVEFKSDNT 695
            .:.:.:|.:.||.|.:..|..|::|||:|...||.|.|:|||.:.|..|....:.||:...:|:.
  Fly  1135 DHLLEIQVENFELEQSPNCSADYLEVRNGGGTDSPLIGRFCGRDIPARIPGFSHEMRLILHTDSA 1199

Mouse   696 VSKKGFK---------------------------------AH----------------------- 704
            ::.:||:                                 ||                       
  Fly  1200 INGRGFRLRWRIFAFGCGGSLRSNMGAISSPRYPNSYPNMAHCEWRISLHPGSGISLLIEDLELE 1264

Mouse   705 -----FFSD---------------KDECSKD-----------NGGC---QQDCVNTFG----SYE 731
                 ::..               |..|..|           |.|.   ..|..|||.    ||:
  Fly  1265 GLSNCYYDSVKIYTGIKLPNQSPCKVLCKDDDLHNPLIQLENNKGTIVFDSDASNTFRGFRISYK 1329

Mouse   732 CQC-----------------------------------------------------------RSG 737
            ..|                                                           ..|
  Fly  1330 ANCIRNLTATTGTIESLNYMEPFWETIPINCSWTIRAPKGNRVLVEVSHLARHEQHVPTATMPGG 1394

Mouse   738 FVLHDNKH------------------------------DCKEAGCEHKVTSTSGTITSPNWPDKY 772
            ..:.|.::                              |.:..||..::..|.|...|||:|..|
  Fly  1395 LYIVDGRNVQEIVTPQAMNISGEVLTVVHNASNVNFQLDYRIDGCMEELRGTFGFFQSPNYPKMY 1459

Mouse   773 PSKKECTWAISSTPGHRVKLTFVEMDIESQPECAYDHLEVFDGRDAKAPVLGRFCGSKKPEPVLA 837
            |:..||.|.|:......::||...:|:|..|.|..|.|.|.:.::: ..|..|.|||.....:.:
  Fly  1460 PNNLECYWLITVEQDSAIELTINNIDLEDSPNCTKDALTVSNHKNS-VEVHERHCGSTTKLVITS 1523

Mouse   838 TGNRMFLRFYSDNSVQRKGFQASHST---ECGGQVRADVKTKDLYSHAQFGDNNYPGGVDCEWVI 899
            :|:|:.:||.||||....||:|::.|   .|||::.|.....:..::..    |||....|||.:
  Fly  1524 SGHRLHVRFISDNSHNGLGFEATYRTVKATCGGKLTARNGVIESPNYPL----NYPAHSRCEWQV 1584

Mouse   900 VAEEGYGVELVFQTFEVEEET--DCGYDYIELFD--GYDSTAPRLGRYCGSGPPEE--VYSAGDS 958
            ...:.:  ::||:..::..|:  ||.:||:|.:|  ..|:...||.:.||....::  :.|:.:.
  Fly  1585 EVSQHH--QIVFEMADLNLESGYDCNWDYLEAYDLTEDDTEGERLFKVCGDETEDDKLLSSSSNM 1647

Mouse   959 VLVKFHSDDTISKKGFHLRY 978
            .:|:|.|||::|||||.|.:
  Fly  1648 AVVRFISDDSVSKKGFRLHF 1667

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Bmp1NP_001346950.1 ZnMc_BMP1_TLD 126..325 CDD:239808
CUB 327..436 CDD:278839 30/116 (26%)
CUB 440..549 CDD:278839 41/113 (36%)
FXa_inhibition 560..592 CDD:317114 0/31 (0%)
CUB 596..705 CDD:278839 38/169 (22%)
FXa_inhibition 712..747 CDD:317114 13/141 (9%)
CUB 752..861 CDD:278839 38/108 (35%)
CUB 865..978 CDD:278839 36/118 (31%)
CubnNP_727348.2 EGF_CA 156..190 CDD:238011
EGF_CA 192..233 CDD:238011
EGF_CA 282..322 CDD:214542
EGF_3 328..366 CDD:289699
EGF 430..457 CDD:278437
EGF_CA 469..503 CDD:238011
CUB 509..622 CDD:238001
CUB 627..737 CDD:238001
CUB 744..849 CDD:294042
CUB 853..970 CDD:238001 31/118 (26%)
CUB 978..1094 CDD:238001 41/115 (36%)
CUB 1100..1211 CDD:238001 36/110 (33%)
CUB 1216..1330 CDD:238001 13/113 (12%)
CUB 1446..1549 CDD:238001 37/103 (36%)
CUB 1554..1667 CDD:238001 36/118 (31%)
CUB 1792..1899 CDD:238001
CUB 1910..1998 CDD:294042
CUB 2019..2133 CDD:238001
CUB 2140..2242 CDD:238001
CUB 2263..2379 CDD:238001
CUB 2385..2511 CDD:238001
CUB 2516..2630 CDD:238001
CUB <2833..2892 CDD:294042
CUB 2898..3008 CDD:238001
CUB 3011..3127 CDD:238001
CUB 3130..3241 CDD:238001
CUB 3254..3363 CDD:238001
CUB 3379..3508 CDD:238001
CUB 3531..3601 CDD:294042
CUB 3623..3733 CDD:238001
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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