Protein Alignment FGD4 and exc-5

DIOPT Version :10

• Sequence 1: XP_047284247.1
• Gene: FGD4 / 121512
• HGNCID: 19125
• Length: 922
• Species: Homo sapiens
• Sequence 2: NP_001294029.1
• Gene: exc-5 / 177692
• WormBaseID: WBGene00001366
• Length: 861
• Species: Caenorhabditis elegans
• Alignment Length: 868
• Identity: 202/868 - (23%)
• Similarity: 375/868 - (43%)
• Gaps: 144/868 - (16%)

Human    85 VPPCSTSSTTTLVGENVSEEEAQGINGNRPAKHSAASPKPQVPPKPLHLQNSPSSNIHQTPRHKA 149
            |||......|.:  :...|||...::|......:...           |.......:.:|.|.|.
 Worm    63 VPPVDLEGGTLI--DATEEEEIDPVDGCTVRVFTYRI-----------LSADEMEELTKTVRQKI 114

Human   150 LPSAKPRMEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGL 214
            .......|..:|...:.....||..::|               .|:|....:.           .
 Worm   115 KFDCTQTMRSLKMIGSEANVVEKSQRIS---------------GDIKGMKPIE-----------F 153

Human   215 TTTPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEPLL 279
            :...:|..|.||..|...||....|         :....||:........:...|..::....|.
 Worm   154 SNNSKQICLDQHSLQLDPNDEQDQQ---------ISRVLNQVPNTFMSLLSREKDMFVKLYPELF 209

Human   280 -----DTHIVNGERDETATAPASPTTDSCDGNASDSS-------------------------YRT 314
                 ::.::.....|..|.|...||.....:.|.||                         |:.
 Worm   210 EKMRTESSLIPSTTTEIITNPDGSTTTRVKSSKSYSSHFSRQETYVNGVKKMSKSKFRAFVEYKG 274

Human   315 PGIGPVLPLEERGAETETKVQERENGESPLE---LEQLDQHHEMK--------ETNEQKLHKIAN 368
            |..|..:.|.: |.|.|....|:|:.::.|.   ..::|...::.        :...||....|.
 Worm   275 PDGGFQVKLSD-GDEFELSEDEQEDDDTSLSQSCYSEIDSESDITGPSPKTDLDKRYQKAWYAAK 338

Human   369 ELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQ 433
            ||:.:|:.||::|.||...|..:|::|.   ....:.:.::.:|:||:..||:...||:|.:.::
 Worm   339 ELVDSEQRYVDKLKLLGDTFRNRLIKEE---LITNDKITRLLANVSSLYQFHNTHFLPQLLESIR 400

Human   434 EWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQ 498
            :|.||.||.::::|.|||||||.||...:|.|.:|.:.:.:: .:|..||:||:||..|..|.|.
 Worm   401 DWHTTKRIANVVRKQAPFLKMYSEYTNNYDRATKLFEELKKK-KKFADVVKEIEKQAECEGLPLG 464

Human   499 HHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIY 563
            ||::.||||:.||::||::|.:.|.|..:|::|...:||::..||:|:|..::|::...|::|:.
 Worm   465 HHLICPVQRVMRYQLLLQEYKKHLQPSDVDFDDTTVALELVLQAAAHANEMMKKLDRFGKVIEVQ 529

Human   564 EMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVG 628
            |.||....:|:|..||:|.|.:.|:::.....:||::||||::::....:..:..||:.:|....
 Worm   530 EQLGNSISLVSPGRELLKSGSVQKISSTTEKTEERFIFLFNDLVILASERKMIGVSKYKLRAVFS 594

Human   629 IDGMKIVETQNEEYPHTFQV-----SGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETF-- 686
            ...|::.|..|.|..|:|.:     :|.:|.:||...:.::|.:|:.::...||.......||
 Worm   595 ASHMQVCEGDNLEREHSFYLRGSDGTGPKRCVELFTPTQKEKNDWVDSIFSIIDEAKAHSLTFTS 659

Human   687 --RNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKC 749
              |::|:::|:                  ...|...|..|...|..|: |...|..|...:|.||
 Worm   660 SSRSSISENNN------------------NSIESKHCADCDIEFGFLS-RGSKCVKCSRRLCKKC 705

Human   750 SDYKAQLEYDGGKLSKVCKDCYQ------IISGFTDSEEKKRKGILEIESAEVSGNSVV-CSFLQ 807
            ...:.    :..|..::|..|.:      |...|: ::...|:.:|::.:   .|:.|: .|.::
 Worm   706 FGRRR----NESKKHRICDTCTKNMDLDGIPRSFS-TQSNMRRNLLQLPA---KGSGVLHSSQIR 762

Human   808 YMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKL-TQSK 871
            :..........:.|:  :|...:|.|.:.:|:.|.|.:||.|..|    :......:|.: ..::
 Worm   763 FRGSLGKLLDRFMVV--RDDFCMYTYSSEEDICALAMLPLPGCEV----KMCGEKFTFSVRVGAR 821

Human   872 SVHSFAADSEELKQKWLKVILLA 894
            .:::..|:.|:.:.|||.::.||
 Worm   822 RMYTMTAEDEQTQMKWLAILDLA 844

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
FGD4	XP_047284247.1	RhoGEF	363..547	CDD:238091	68/183 (37%)
		PH1_FDG4	579..672	CDD:275434	25/97 (26%)
		FYVE_FGD1_2_4	710..774	CDD:277280	14/69 (20%)
		PH2_FGD1-4	793..895	CDD:270056	22/104 (21%)
exc-5	NP_001294029.1	RhoGEF	336..514	CDD:214619	68/181 (38%)
		PH1_FGD1-4_like	545..643	CDD:275423	25/97 (26%)
		FYVE	676..727	CDD:214499	13/55 (24%)
		PH-like	<773..845	CDD:473070	19/78 (24%)