DRSC/TRiP Functional Genomics Resources

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Protein Alignment Bmi1 and Su(z)2

DIOPT Version :10

Sequence 1:NP_031578.2 Gene:Bmi1 / 12151 MGIID:88174 Length:324 Species:Mus musculus
Sequence 2:NP_001260933.1 Gene:Su(z)2 / 36432 FlyBaseID:FBgn0265623 Length:1396 Species:Drosophila melanogaster


Alignment Length:341 Identity:103/341 - (30%)
Similarity:155/341 - (45%) Gaps:55/341 - (16%)


- Green bases have known domain annotations that are detailed below.


Mouse     9 ITELNPHLMCVLCGGYFIDATTIIECLHSFCKTCIVRYLETSKYCPICDVQVHKTRPLLNIRSDK 73
            :.:.:..:.|.||.||.||.||:..|.|::|::||:::|..:.|||.|.....|....||::||.
  Fly    26 VRQFHDLITCRLCRGYMIDPTTVDYCYHTYCRSCILKHLLRAVYCPECKASGGKEINELNLKSDD 90

Mouse    74 TLQDIVYKLVPGLFKNEMKRRRDFYAAHPSADAANGSNEDRGEVADEEKRIITDDEIISLSIEFF 138
            ||:.::|||||||::.|.|...||...|...|          |...:|....|..|:||||:|:.
  Fly    91 TLRSLIYKLVPGLYQRECKELADFKEQHDLVD----------EQTTDEPEFFTTTELISLSLEYH 145

Mouse   139 DQSRLDRKVNKEKPKEEVNDKRYLRCPAAMTVMHLRKFLRSKMDIP---NTFQIDVMYEEEPLKD 200
                 ...:::..| .||....||:|.|.:.|..|::||.||.:|.   ...:::|.|::|.|..
  Fly   146 -----PAMLHQCGP-GEVPPTIYLQCAAGLPVELLKRFLCSKYNIETDNGLVEVEVTYKDEVLPT 204

Mouse   201 YYTLMDIAYIYTWRRNGPLPLKYR----------------------VRPTCKRMKMSHQRDGLTN 243
            .:||||:||.|.|.|..|:...||                      :.|. ..::.|.....:|.
  Fly   205 NFTLMDVAYCYNWSRESPMAFCYRILLYDNEQTKNDENNLSRINQDIEPE-HSVRRSKSAKSVTF 268

Mouse   244 AGELES--DSGSDKANSPAGGVPSTSSCLPSPSTPVQSPHPQFPHISSTMNGTSNSPSANHQSSF 306
            |.:|||  ||||.:         |...|...|.....|.:.:.  .||.......||.:|.:|..
  Fly   269 AEDLESEIDSGSPR---------SKVRCKTPPKVSPSSKNKRL--TSSKREAEPESPVSNFKSLR 322

Mouse   307 ASRPRKSSLNGSSATS 322
            ::..|.|....|...|
  Fly   323 SNDMRYSDYAVSKVKS 338

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Bmi1NP_031578.2 RING-HC_PCGF4 5..101 CDD:438394 37/91 (41%)
Nuclear localization signal. /evidence=ECO:0000255 81..95 8/13 (62%)
RAWUL_PCGF4 130..224 CDD:340685 33/96 (34%)
Interaction with PHC2. /evidence=ECO:0000250|UniProtKB:P35226 160..180 8/19 (42%)
Interaction with E4F1. /evidence=ECO:0000250|UniProtKB:P35226 162..226 26/88 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 232..324 24/93 (26%)
Su(z)2NP_001260933.1 RING-HC_PCGF5 23..117 CDD:438395 37/90 (41%)
RAWUL_PCGF2_like 137..228 CDD:340602 33/96 (34%)

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