DRSC/TRiP Functional Genomics Resources

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Protein Alignment ERP27 and hlk

DIOPT Version :10

Sequence 1:NP_689534.1 Gene:ERP27 / 121506 HGNCID:26495 Length:273 Species:Homo sapiens
Sequence 2:NP_001163065.1 Gene:hlk / 46017 FlyBaseID:FBgn0010482 Length:1786 Species:Drosophila melanogaster


Alignment Length:353 Identity:59/353 - (16%)
Similarity:114/353 - (32%) Gaps:141/353 - (39%)


- Green bases have known domain annotations that are detailed below.


Human    17 CELAAEVAAEVE-------------------KSSDGPGAAQEPTWL---TDVPAAMEFIAATEVA 59
            ||...:|..|:|                   ..:||.|..:.|..:   ..:|...|...:.|..
  Fly  1347 CEQCTKVLEELENIDDDCDKHGITFVKTRDFSVADGYGVHEYPALVYFEGGIPNVFEGELSEEEE 1411

Human    60 VIGFF-----QD-LEIPAVPILHSMVQK-------------------FPGVS--------FGIS- 90
            |:.:.     :| :|:....:|.:||::                   ..|:.        |||. 
  Fly  1412 VLQWLITQKTEDRIELITRQMLETMVEETQYLAVYFYKINCNICDQILEGLELIDDECDVFGIHM 1476

Human    91 ---TDSEVLTHYNI----------TGNTICLFR------------LVDNEQLNLEDEDIESIDAT 130
               .|.::...|:|          .||.: ||.            |:|::...|.|| ||.::..
  Fly  1477 VKIQDPQLAKRYSIKTFPALVYFRNGNPL-LFEGDLQNEQSVLEWLIDDDNRELADE-IEEVNER 1539

Human   131 KLSR----------------------------------------FIEINSLHMVTEYNPVTVIGL 155
            .|.|                                        |::|.|:....:|        
  Fly  1540 MLDRLMAESTLLVVFFYDDDCAECEEILEELEEIDGEADMFGIDFVKIASIQAAKKY-------- 1596

Human   156 FNSVIQIHLLLIMNKASPE-YEENMHRYQKAAKLFQGKILFILVDSGMKENGKVISFFKLKESQL 219
              .::.|..|:...|..|. |:.::|::.|.......:.:|.:.:...:.|.|::... |:|::.
  Fly  1597 --EIVNIPSLVYFRKQVPVLYDGDLHQHDKVITWLTSQDVFEIKNEIEEVNRKMLDKL-LEENEF 1658

Human   220 PALAIYQTLDDEWDTLPTAEVSVEHVQN 247
            .|:..|:      ...|.:..::|.::|
  Fly  1659 LAVFFYE------HNQPDSTAALEKLEN 1680

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ERP27NP_689534.1 Thioredoxin_6 64..250 CDD:463999 46/284 (16%)
PDIA3-binding site. /evidence=ECO:0000269|PubMed:16940051 230..233 0/2 (0%)
Prevents secretion from ER. /evidence=ECO:0000305|PubMed:16940051 270..273
hlkNP_001163065.1 PDI_a_family 50..145 CDD:239259
ER_PDI_fam 381..>670 CDD:273457
PDI_a_family 384..479 CDD:239259
ER_PDI_fam 700..>916 CDD:273457
PDI_a_family 1129..1226 CDD:239259
TRX_family 1433..>1502 CDD:239245 10/68 (15%)
Blue background indicates that the domain is not in the aligned region.

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