DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Blm and Blm

DIOPT Version :9

Sequence 1:NP_031576.4 Gene:Blm / 12144 MGIID:1328362 Length:1419 Species:Mus musculus
Sequence 2:NP_524319.2 Gene:Blm / 41366 FlyBaseID:FBgn0002906 Length:1487 Species:Drosophila melanogaster


Alignment Length:1553 Identity:478/1553 - (30%)
Similarity:716/1553 - (46%) Gaps:329/1553 - (21%)


- Green bases have known domain annotations that are detailed below.


Mouse    15 QLQRHSARKLNNQP--SLSKPKSLGFTFKKKTSEGDVSVTSVSVVKTPALSDKD-----VNVSEA 72
            :|::|:...|:..|  .||..|....:.||.||. |:||:.::.:.... ||:|     |....:
  Fly    82 KLKKHTYLDLSVSPLAKLSAKKYARDSPKKPTSL-DLSVSPLAELLAKK-SDRDSPKKPVQNENS 144

Mouse    73 FSF---TESP---------LHKPKQQAK--------------------------IEGF-FKHFPG 98
            :::   :|||         |.||.|:.:                          ::.| |:.||.
  Fly   145 YTYRGLSESPVENKSIGDTLRKPPQKERKTSIVWLSDSPEKKVTQNERKILDSPLQRFSFEDFPN 209

Mouse    99 RQQSKGTCSEPSLPATVQTAQDTLCTTPKTPTAKKLPVAVFKKLEFSSSADSLSDWADMDDFDMS 163
            ::...               :..|.|.|.:|...: ||...:|..:.:...::.|          
  Fly   210 KENGN---------------RHHLLTLPDSPPPPQ-PVKKPEKTMWQNETKTIQD---------- 248

Mouse   164 ASDAFAS-LAKNPATRVST-------AQKMKKTKRNFFKPPPRKA---------NAVKTDLTPPS 211
             .|:.|: |..|....:||       ....|.:.||.|:..|.|:         .:.|.:..|..
  Fly   249 -KDSPANPLVSNNLASISTLLDSSRAPNTYKGSSRNLFEDSPEKSGSGEQGYKLGSAKENEIPTK 312

Mouse   212 PECLQVDLTKESEEEEEEEEEAEGADCLSRDVICIDNDSAS--EELTEKDT-------QESQSLK 267
            |      .|...|........:..|....|..:..||..|.  ::|.:.|.       |.:::||
  Fly   313 P------ATASLERNSVTSSPSPAAPLKPRYSVAFDNSLADYLKDLAQNDNFSIDPNKQNTETLK 371

Mouse   268 AHLGAERGDSEKKSHEDEAVFHSVQNTEYFEHNDNDYD-IDFVPP---------SPEEIISTASS 322
            :.||..|                  || |.|..:.... ||.:|.         .|...:.....
  Fly   372 STLGFFR------------------NT-YVELMEKYCSLIDQIPAMHFNEIAGFQPNTFLKLKVM 417

Mouse   323 SLKCSSMLKDLDDS-DKEKGILSTSEELLSKPE-EMTTHK------SDAGTSK-----------D 368
            ..|..:..:.:.:| ||::..|...:|.|.|.| ||...:      |.:...|           :
  Fly   418 RQKFKARTQLVQNSLDKKESQLKAEQEALEKEEIEMQAEQAQQTVLSSSSPEKSRPIMPLPKVQE 482

Mouse   369 CDAQQIRIQQQLIHVMEHICKLVD-----TVPTDELEALNCGTELLQQRNIRRKLLAEAGFNGND 428
            ...::|..:.||||   .:|...|     :.|.|        |:|:.:   |::|:       ||
  Fly   483 IKDEKIPNRNQLIH---DLCGEPDNFSPPSSPRD--------TQLIPK---RQQLI-------ND 526

Mouse   429 VRLLGSLWRHRPDSLDNTVQGDSCPVGHPNKELNSPYLLSHSPSTEECLPTTTPGKTGFSATPKN 493
              |.|     .||        |..|   |:|: |.|:||.   ..||.:              .:
  Fly   527 --LCG-----EPD--------DFSP---PSKQ-NDPHLLR---KCEELV--------------HD 555

Mouse   494 LFERPLLNSHLQKSFVSSNWAETPRMENRNESTDFPG---------SVLTSTTVKAQSKQAASGW 549
            |.|.|  :.:|.:|.:.....|..::....:.|...|         .:|.....:.|..|   |.
  Fly   556 LCEEP--DDYLAQSMMLDGDLEEEQLNGPTQGTTTSGMDDDEDDLEGLLAEIEDEHQKMQ---GR 615

Mouse   550 NVERHGQASYDID-------------NFNIDDFDDDDDDDDWENIMHNFPASKSSTATYPPIKEG 601
            ..|.:|.:..:::             |.::||....:.|:.....||:..|:..|.     :...
  Fly   616 RSEFNGYSYKELEAVKVKEKHKETPINISLDDDGFPEYDEAMFEQMHSQAAANKSR-----VSSA 675

Mouse   602 GPVKSLSERISSAKAKFLPVVSTAQNTNLSESIQNCSDKLAQNLSSKNPKHE----HFQSLNFPH 662
            ||..|.|            ||.|.|.:.|.      |.||:.|..: |..::    .|....|.|
  Fly   676 GPSTSKS------------VVPTKQTSALH------SQKLSGNFHA-NVHNDGITGEFDGQKFEH 721

Mouse   663 TKEMMKIFHKKFGLHNFRTNQLEAINAALLGEDCFILMPTGGGKSLCYQLPACVSPGVTIVISPL 727
            :..:|......|||.:||.|||:.|||.|||.|||:||||||||||||||||.::.|||||||||
  Fly   722 STRLMHGLSYSFGLKSFRPNQLQVINATLLGNDCFVLMPTGGGKSLCYQLPAILTEGVTIVISPL 786

Mouse   728 RSLIVDQVQKLTSFDIPATYLTGDKTDSEAANIYLQLSKKDPIIKLLYVTPEKVCASNRLISTLE 792
            :|||.||:.||.|.||.|..|:|::..::...||..|..:.|::|||||||||:.:|.|...||:
  Fly   787 KSLIFDQINKLASLDICAKSLSGEQKMADVMAIYRDLESQPPMVKLLYVTPEKISSSARFQDTLD 851

Mouse   793 NLYERKLLARFVIDEAHCVSQWGHDFRQDYKRMNMLRQKFPSVPVMALTATANPRVQKDILTQLK 857
            .|.....::||||||||||||||||||.|||::.:|:::||:||.:||||||.|||:.|||.||.
  Fly   852 TLNSNNYISRFVIDEAHCVSQWGHDFRPDYKKLGVLKKRFPNVPTIALTATATPRVRLDILAQLN 916

Mouse   858 ILRPQVFSMSFNRHNLKYYVLPKKPKKVAFDCLEWIRKHHPYDSGIIYCLSRRECDTMADTLQRE 922
            :...:.|..||||.||:|.|||||......|...:||....:.|||||||||:|||..:..:.::
  Fly   917 LKNCKWFLSSFNRSNLRYRVLPKKGVSTLDDISRYIRSKPQHFSGIIYCLSRKECDETSKKMCKD 981

Mouse   923 GLAALAYHAGLSDSARDEVQHKWINQDNCQVICATIAFGMGIDKPDVRFVIHASLPKSMEGYYQE 987
            |:.|::|||||:|:.|:..|..|:. ...:|||||:||||||||||||||:|.|||||:||||||
  Fly   982 GVRAVSYHAGLTDTDRESRQKDWLT-GKMRVICATVAFGMGIDKPDVRFVLHYSLPKSIEGYYQE 1045

Mouse   988 SGRAGRDGEISHCVLFYTYHDVTRLKRLIMMEKDGNYHTKETHVNNLYSMVHYCENITECRRIQL 1052
            :|||||||:::.|:|:|.|.|:.|:|:::..:|...|:.|:.||:|||.:|.||||:|:|||.|.
  Fly  1046 AGRAGRDGDVADCILYYNYSDMLRIKKMLDSDKALQYNVKKIHVDNLYRIVGYCENLTDCRRAQQ 1110

Mouse  1053 LAYFGEKGFNPDFCKKYPDVSCDNCCKTKDYKTKDVTDDVKNIIRFVQEHSSSPGTRNIGPAGRF 1117
            |.||||. |..:.|.:..:.:||||...:.||..|..:..:...|.|::..|.        ..||
  Fly  1111 LDYFGEH-FTSEQCLENRETACDNCINKRAYKAVDALEHARKAARAVKDLCSG--------RSRF 1166

Mouse  1118 TLNMLVDIFLGSKSAKV------KSGIFGKGTTYSRHNAERLFKKLILDKILDEDLYINANDQPI 1176
            ||..:.|:..|||..|:      |:...|....:.:::..||.:|:::|..|.||| |..||.|.
  Fly  1167 TLLHIADVLKGSKIKKIIDFNHHKTPHHGVLKDWDKNDVHRLLRKMVIDGFLREDL-IFTNDFPQ 1230

Mouse  1177 AYVMLGTKAHSVLSGHLKVDFMETENSSSIKKQKALVAKVSQ------------REEVVKKCLGE 1229
            ||:.||.....::.|....:|..|:|:   |:.||.|..||.            ..|:.::|..:
  Fly  1231 AYLYLGNNISKLMEGTPNFEFAVTKNA---KEAKAAVGSVSDGATSSTADGQSGMREIHERCYTD 1292

Mouse  1230 LTEVCKLLGKVFGVHYFNIFNTATLKKLAESLSSDPEVLLQIDGVTEDKLEKYGAEVIPVLQKYS 1294
            |.::|:.:.....|...:|.|...||.:||:|....:.:..|..||:...:||||:::.:...|:
  Fly  1293 LLDLCRTIASQRNVTMASIMNIQALKSMAETLPITEKDMCSIPHVTKANFDKYGAKLLEITSNYA 1357

Mouse  1295 ------EWTVPAEDGSPGARGAPE----DTEEEEEEAPVSSHYFAN-------QTRNERKRKKMS 1342
                  :..:..|:....|:..|.    :.|..:.:..|:|...||       .:....||||:.
  Fly  1358 SEKLLMQAVLDEEEEQAAAKQRPSTSGWNNESVDWDMAVASQGNANTSGASGFNSFRAGKRKKIY 1422

Mouse  1343 ATHKPKRRRTSYGGFRAKGGSTTCRKTTSKSKFYGVTGS-RSASCASQATSSASRKLG 1399
            .:...||.:||       ..|...|||||.....|..|: |:.|.||.|:...|:|.|
  Fly  1423 KSGASKRYKTS-------TTSPAARKTTSARGRGGRAGAKRAESSASSASGWKSKKTG 1473

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
BlmNP_031576.4 BLM_N 4..371 CDD:292819 88/456 (19%)
BDHCT 382..417 CDD:285334 8/39 (21%)
BDHCT_assoc 433..658 CDD:292821 50/250 (20%)
recQ_fam 668..1151 CDD:129701 243/488 (50%)
DEAD 680..852 CDD:278688 104/171 (61%)
HELICc 872..1003 CDD:238034 73/130 (56%)
RecQ_Zn_bind 1008..1077 CDD:292742 30/68 (44%)
RQC 1087..1189 CDD:214936 31/107 (29%)
HRDC 1221..1297 CDD:128635 20/81 (25%)
BlmNP_524319.2 RQC 1140..1253 CDD:286470 37/118 (31%)
HRDC 1286..1352 CDD:278967 18/65 (28%)
RecQ 729..1359 CDD:223588 290/647 (45%)
DEAD 739..908 CDD:278688 100/168 (60%)
HELICc 931..1061 CDD:238034 74/129 (57%)
RecQ_Zn_bind 1066..1134 CDD:292742 31/67 (46%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167849802
Domainoid 1 1.000 215 1.000 Domainoid score I2714
eggNOG 1 0.900 - - E1_COG0514
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 574 1.000 Inparanoid score I1044
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D360651at33208
OrthoFinder 1 1.000 - - FOG0001239
OrthoInspector 1 1.000 - - oto94451
orthoMCL 1 0.900 - - OOG6_100352
Panther 1 1.100 - - LDO PTHR13710
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X2611
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.760

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