DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRIG3 and Lrig3

DIOPT Version :9

Sequence 1:	NP_700356.2	Gene:	LRIG3 / 121227	HGNCID:	30991	Length:	1119	Species:	Homo sapiens
Sequence 2:	NP_796126.4	Gene:	Lrig3 / 320398	MGIID:	2443955	Length:	1117	Species:	Mus musculus

Alignment Length:	1119	Identity:	962/1119 - (85%)
Similarity:	1023/1119 - (91%)	Gaps:	2/1119 - (0%)

- Green bases have known domain annotations that are detailed below.

Human     1 MSAPSLRARAAGLGLLLCAVLGRAGRSDSGGRGELGQPSGVAAERPCPTTCRCLGDLLDCSRKRL 65
            |.||.|||..|.|||||||.|||||.:.|||.|..||.....|:||||..|.||||||||||:||
Mouse     1 MGAPGLRAATAALGLLLCAGLGRAGPAGSGGHGAPGQLLDDDAQRPCPAACHCLGDLLDCSRRRL 65

Human    66 ARLPEPLPSWVARLDLSHNRLSFIKASSMSHLQSLREVKLNNNELETIPNLGPVSANITLLSLAG 130
            .|||:|||:||.||||||||||||:.||:||||||:||||||||||||||||.:||||..|||||
Mouse    66 VRLPDPLPAWVTRLDLSHNRLSFIQTSSLSHLQSLQEVKLNNNELETIPNLGSISANIRQLSLAG 130

Human   131 NRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLL 195
            |.|.:||||.|:.||||||||||:||||||:||||.|||||||:|:|||:|||||||||||:|||
Mouse   131 NAIDKILPEQLEAFQSLETLDLSNNNISELRTAFPPLQLKYLYINNNRVSSMEPGYFDNLASTLL 195

Human   196 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFW 260
            |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   196 VLKLNRNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFW 260

Human   261 GLSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 325
            ||||||:||||||||||||||||||||||:|||||||||||||||||||||||||||||||||||
Mouse   261 GLSNMEVLQLDHNNLTEITKGWLYGLLMLRELHLSQNAINRISPDAWEFCQKLSELDLTFNHLSR 325

Human   326 LDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRR 390
            |||||||||||||.||||||:||||||||||||:|||||||:|||||||||||:|||||||:||:
Mouse   326 LDDSSFLGLSLLNALHIGNNKVSYIADCAFRGLTSLKTLDLRNNEISWTIEDMSGAFSGLDRLRQ 390

Human   391 LILQGNRIRSITKKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWL 455
            ||||||||||||||||.|||.|||||||.|||||||.|||||||||||||||||||||||||:||
Mouse   391 LILQGNRIRSITKKAFAGLDTLEHLDLSGNAIMSLQSNAFSQMKKLQQLHLNTSSLLCDCQLRWL 455

Human   456 PQWVAENNFQSFVNASCAHPQLLKGRSIFAVSPDGFVCDDFPKPQITVQPETQSAIKGSNLSFIC 520
            |||||||||||||||||||||||||||||.|||||||||||||||||||||||||||||::||.|
Mouse   456 PQWVAENNFQSFVNASCAHPQLLKGRSIFTVSPDGFVCDDFPKPQITVQPETQSAIKGSDVSFTC 520

Human   521 SAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQGGEVMEYTTILRLREVEFASEGKYQCVISN 585
            |||||||||||||||||||.|.||||||||||||||||:||||||||||.|||.|||||||||||
Mouse   521 SAASSSDSPMTFAWKKDNEALQDAEMENYAHLRAQGGELMEYTTILRLRNVEFTSEGKYQCVISN 585

Human   586 HFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 650
            |||||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   586 HFGSSYSVKAKLTINMLPSFTKTPMDLTIRAGAMARLECAAVGHPAPQIAWQKDGGTDFPAARER 650

Human   651 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSISANATLTVLETPSFLRPLLDRTVTKGETAV 715
            ||||||||||||||||||||||||||||||||||:||||||||||||||||||||||||||||||
Mouse   651 RMHVMPEDDVFFIVDVKIEDIGVYSCTAQNSAGSVSANATLTVLETPSFLRPLLDRTVTKGETAV 715

Human   716 LQCIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 780
            |||||||||||:|||||||||||||||||||||||||||||||||||||||||||||||||||||
Mouse   716 LQCIAGGSPPPRLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNV 780

Human   781 RLSVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNT 845
            |||||||||||||.|||||||.|||||||||||||||||||||||||||||||||||||||||||
Mouse   781 RLSVIPTPTCDSPHMTAPSLDGDGWATVGVVIIAVVCCVVGTSLVWVVIIYHTRRRNEDCSITNT 845

Human   846 DETNLPADIPSYLSSQGTLADRQDGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTCHIDNSSEAD 910
            ||||||||||||||||||||||||||:|||||||||||||||.||||||||.:||||.|:|||||
Mouse   846 DETNLPADIPSYLSSQGTLADRQDGYISSESGSHHQFVTSSGGGFFLPQHDGAGTCHFDDSSEAD 910

Human   911 VEAATDLFLCPFLGSTGPMYLKGNVYGSDPFETYHTGCSPDPRTVLMDHYEPSYIKKKECYPCSH 975
            ||||:|.|||||:|||||:||:||:|..||||.|..|||.||||.||||.|.||: |::.:.|:.
Mouse   911 VEAASDPFLCPFVGSTGPVYLQGNLYSPDPFEVYLPGCSSDPRTALMDHCESSYV-KQDRFSCAR 974

Human   976 PSEESCERSFSNISWPSHVRKLLNTSYSHNEGPGMKNLCLNKSSLDFSANPEPASVASSNSFMGT 1040
            ||||.||||..:|.|| |.|||.:::|..|||..::.|||||||:|||..|||.|..||||||||
Mouse   975 PSEEPCERSLKSIPWP-HSRKLTDSTYPPNEGHTVQTLCLNKSSVDFSTGPEPGSATSSNSFMGT 1038

Human  1041 FGKALRRPHLDAYSSFGQPSDCQPRAFYLKAHSSPDLDSGSEEDGKERTDFQEENHICTFKQTLE 1105
            |||.||||||||:||..||.|||||..:.|:.|||:|||.|||:.||||||:||||.||::|...
Mouse  1039 FGKPLRRPHLDAFSSSAQPPDCQPRPCHGKSLSSPELDSESEENDKERTDFREENHRCTYQQIFH 1103

Human  1106 NYRTPNFQSYDLDT 1119
            .||||:.|..|.||
Mouse  1104 TYRTPDCQPCDSDT 1117

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRIG3	NP_700356.2	LRR	20..395	CDD:227223	323/374 (86%)
		leucine-rich repeat	58..74	CDD:275378	12/15 (80%)
		LRR_RI	<65..>245	CDD:238064	154/179 (86%)
		LRR 1	75..96		16/20 (80%)
		leucine-rich repeat	78..99	CDD:275378	17/20 (85%)
		LRR 2	99..120		18/20 (90%)
		leucine-rich repeat	100..115	CDD:275378	13/14 (93%)
		LRR 3	122..142		13/19 (68%)
		leucine-rich repeat	123..146	CDD:275378	14/22 (64%)
		LRR 4	146..167		18/20 (90%)
		leucine-rich repeat	147..168	CDD:275380	17/20 (85%)
		LRR 5	168..189		17/20 (85%)
		leucine-rich repeat	169..192	CDD:275380	19/22 (86%)
		LRR 6	193..214		20/20 (100%)
		leucine-rich repeat	194..216	CDD:275380	21/21 (100%)
		LRR 7	216..237		20/20 (100%)
		leucine-rich repeat	217..240	CDD:275380	22/22 (100%)
		LRR 8	240..261		20/20 (100%)
		leucine-rich repeat	241..264	CDD:275380	22/22 (100%)
		LRR_RI	262..>446	CDD:238064	170/183 (93%)
		LRR 9	264..285		19/20 (95%)
		leucine-rich repeat	265..288	CDD:275380	21/22 (95%)
		LRR 10	288..309		19/20 (95%)
		leucine-rich repeat	289..312	CDD:275380	21/22 (95%)
		LRR 11	312..333		20/20 (100%)
		leucine-rich repeat	313..336	CDD:275380	22/22 (100%)
		LRR 12	336..357		18/20 (90%)
		leucine-rich repeat	337..360	CDD:275380	20/22 (91%)
		LRR 13	360..382		19/21 (90%)
		leucine-rich repeat	361..385	CDD:275380	21/23 (91%)
		LRR_8	387..442	CDD:290566	48/54 (89%)
		LRR 14	387..408		18/20 (90%)
		leucine-rich repeat	388..411	CDD:275380	20/22 (91%)
		LRR 15	411..432		17/20 (85%)
		leucine-rich repeat	412..435	CDD:275380	20/22 (91%)
		LRRCT	446..494	CDD:214507	45/47 (96%)
		Ig_3	498..585	CDD:290638	78/86 (91%)
		I-set	499..599	CDD:254352	91/99 (92%)
		I-set	603..693	CDD:254352	88/89 (99%)
		Ig_1	620..694	CDD:143240	72/73 (99%)
		I-set	697..784	CDD:254352	85/86 (99%)
		IGc2	711..774	CDD:197706	61/62 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1093		15/19 (79%)
Lrig3	NP_796126.4	LRR 1	75..98		18/22 (82%)
		LRR_8	76..133	CDD:290566	47/56 (84%)
		leucine-rich repeat	76..99	CDD:275378	18/22 (82%)
		LRR_RI	81..324	CDD:238064	219/242 (90%)
		LRR 2	99..120		18/20 (90%)
		leucine-rich repeat	100..146	CDD:275378	34/45 (76%)
		LRR_8	122..179	CDD:290566	43/56 (77%)
		LRR 3	122..143		14/20 (70%)
		LRR 4	146..168		18/21 (86%)
		leucine-rich repeat	147..168	CDD:275380	17/20 (85%)
		LRR_8	168..227	CDD:290566	54/58 (93%)
		leucine-rich repeat	169..192	CDD:275380	19/22 (86%)
		LRR 5	169..189		16/19 (84%)
		LRR 6	193..214		20/20 (100%)
		leucine-rich repeat	194..216	CDD:275380	21/21 (100%)
		LRR_8	215..275	CDD:290566	58/59 (98%)
		LRR 7	216..237		20/20 (100%)
		leucine-rich repeat	217..240	CDD:275380	22/22 (100%)
		LRR 8	240..261		20/20 (100%)
		leucine-rich repeat	241..264	CDD:275380	22/22 (100%)
		LRR_RI	262..>446	CDD:238064	170/183 (93%)
		LRR_8	263..323	CDD:290566	57/59 (97%)
		LRR 9	264..285		19/20 (95%)
		leucine-rich repeat	265..288	CDD:275380	21/22 (95%)
		LRR 10	288..309		19/20 (95%)
		leucine-rich repeat	289..312	CDD:275380	21/22 (95%)
		LRR_8	312..371	CDD:290566	54/58 (93%)
		LRR 11	312..333		20/20 (100%)
		leucine-rich repeat	313..336	CDD:275380	22/22 (100%)
		LRR 12	336..357		18/20 (90%)
		leucine-rich repeat	337..360	CDD:275380	20/22 (91%)
		LRR_8	359..422	CDD:290566	54/62 (87%)
		LRR 13	360..382		19/21 (90%)
		leucine-rich repeat	361..385	CDD:275380	21/23 (91%)
		LRR 14	387..408		18/20 (90%)
		leucine-rich repeat	388..411	CDD:275380	20/22 (91%)
		LRR 15	411..432		17/20 (85%)
		leucine-rich repeat	412..433	CDD:275380	18/20 (90%)
		LRRCT	446..494	CDD:214507	45/47 (96%)
		I-set	499..599	CDD:254352	91/99 (92%)
		Ig	500..587	CDD:299845	78/86 (91%)
		I-set	603..693	CDD:254352	88/89 (99%)
		Ig_1	620..694	CDD:143240	72/73 (99%)
		I-set	697..784	CDD:254352	85/86 (99%)
		IGc2	711..774	CDD:197706	61/62 (98%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1093		52/73 (71%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83952081
Domainoid	1	1.000	523	1.000	Domainoid score	I6894
eggNOG	1	0.900	-	-		E2759_KOG4194
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H62452
Inparanoid	1	1.050	1951	1.000	Inparanoid score	I1711
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG49439
OrthoDB	1	1.010	-	-		D161719at2759
OrthoFinder	1	1.000	-	-		FOG0001817
OrthoInspector	1	1.000	-	-		oto127620
orthoMCL	1	0.900	-	-		OOG6_104558
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3392
SonicParanoid	1	1.000	-	-		X1179
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	18	18.200