DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRIG3 and cyr1

DIOPT Version :9

Sequence 1:	NP_700356.2	Gene:	LRIG3 / 121227	HGNCID:	30991	Length:	1119	Species:	Homo sapiens
Sequence 2:	NP_596159.1	Gene:	cyr1 / 2540810	PomBaseID:	SPBC19C7.03	Length:	1692	Species:	Schizosaccharomyces pombe

Alignment Length:	1123	Identity:	230/1123 - (20%)
Similarity:	380/1123 - (33%)	Gaps:	338/1123 - (30%)

- Green bases have known domain annotations that are detailed below.

Human    58 LDCSRKRLARLPEPLPSWVAR----LDLSHNRLSFIKASSMSHL--QSLREVKLNNNELETIPNL 116
            ||.|..  .|.|...|....|    |::|.|.:..:.....|.|  .||:|:.:.||:|..:|:.
pombe   458 LDISNN--LRSPRGKPITALRQLEVLNMSRNDIYELDPLIFSGLSRNSLKELNIANNKLFFLPHS 520

Human   117 GPVSANITLLSLAGNRIVEILPEHLKEFQSLETLDLSSNNISELQTAFPAL-QLKYLYLN----S 176
            .....|:|.|.|:.|..| ..|..:.|...||||:.|.|.:|::.:...:| :||:|||.    |
pombe   521 TRYLVNLTYLDLSYNNFV-TFPLIITELSQLETLNFSHNLLSQISSKIGSLVKLKHLYLQFNDLS 584

Human   177 NR--------------------------------------------------------------V 179
            ||                                                              :
pombe   585 NRLPQEIGLLKNLETIDLSYNAITNIASLSECPKLNSINVACNLLSFYEYSNPSATFIDFSFCPL 649

Human   180 TSMEPG-------YF-----------DNLANTLL---VLKLNRN--------------------- 202
            |:::|.       ||           |::..||:   .:|:|.|
pombe   650 TTIDPAFSYSNLVYFDISHAKLIGLKDSVIETLVNVETVKVNYNHFTSISDAISAMQNLKYLSCT 714

Human   203 --RISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWG---- 261
              .:|.:.|.:.||..|.||:|:.|.||......:| :.:||.:.:..|.:.|:.......
pombe   715 NCEMSYVSPNLGKLKHLVHLDLHANNIKIFPEEVWQ-VSSLKVVNLSSNILEKIKLPVATSKKLT 778

Human   262 --LSNMEILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLTFNHLS 324
              :|.::|::....|.........:.:..::||:|..|.:......|.|:.:.|..|:|::|:|:
pombe   779 RTISQLKIMRTLSGNPVSSLSSQEFVMPTVEELYLVDNRLGNDCFTALEYFKCLKVLNLSYNYLT 843

Human   325 RLDDSSFLGLSLLNTLHIGNNRVSYIADCAFRGLSS-----LKTLDLKNNEISWTIEDMNGAFSG 384
            .:....|...|.|..|.:..|.::.::      :||     |:||....|.:|  ....|.|.|
pombe   844 EIPSKFFQNFSDLKHLFVSGNELANLS------ISSTAQVLLETLYANGNRLS--SFPKNEALS- 899

Human   385 LDKLRRLILQGNRIRSIT-----KKAFTGLDALEHLDLSDNAIMSLQGNAFSQMKKLQQLHLNTS 444
             ..||.|.:..|.::::.     ||:.|.|..||:|:||        ||.:.:..:.:..:...|
pombe   900 -KSLRFLDISTNNLQNLAVEKAEKKSLTKLPQLEYLNLS--------GNTWFRFSEHEDTNFTKS 955

Human   445 SLLCDCQLKWLPQWVAENNFQS--------FVNASCAHPQLLK-------GRSIFAVSPDGFVCD 494
            .|.   .||:|........|.:        |:..:...|.:|:       .|||..:|....|.:
pombe   956 YLK---NLKFLSIMDLNTKFSNAPSDVLNHFIQRNSPQPNILRYGVCGYLSRSIPVISACELVVN 1017

Human   495 DFPKPQITVQPETQSAIK-GSN---LSFICSAASSSDSPMTFAWKKDNELLHDAEMENYAHLRAQ 555
            :|..||.::.....|.|. |.|   |.|:....:|..:....|....:|.:.:|....:..|..:
pombe  1018 NFLHPQSSLYCVLDSDISAGKNNRVLKFVYDNLASCLAHEINAADSSSEQICNALRRGFLRLNKK 1082

Human   556 GGEVMEYTTILRLREVEFASEGKYQCVISNHFGSSYSVKAKLTVNMLPSFTKTPMDLTIRAGAMA 620
            .|.|:.|       ::..:|||.   |.||:.                    |.|:::.:..:|.
pombe  1083 LGNVIHY-------DLRKSSEGD---VDSNYV--------------------TTMNISEKGYSMD 1117

Human   621 RLECAAVG------HPAPQIAWQKDGGTDFPAARERR---------MH-VMPEDDVFFIVDVKIE 669
            . .|..:|      :.....|:..:.||.......|.         || |...|::..|||....
pombe  1118 S-SCLDIGVSIILVYVRDTRAFVANVGTSMAIMSTRNDSEPTTLSVMHDVYNRDEIRRIVDSCGF 1181

Human   670 DIGVYSCTAQNSAGSIS----------ANA-------TLTVLETPSFLRPLLDRTVTKGETAVLQ 717
            ..|....|...:.|.:|          .|.       ...:|....|...|..||       |:.
pombe  1182 ISGEIKSTTTRAIGRLSQFPGVQAVPYVNVQYLSELNEFIILANQEFWSVLSKRT-------VID 1239

Human   718 CIAGGSPPPKLNWTKDDSPLVVTERHFFAAGNQLLIIVDSDVSDAGKYTCEMSNTLGTERGNVRL 782
            .:......|.|..||.....:.    :.|..|.|::||:.:    |.:. |.|......||:.:.
pombe  1240 VVRANRHSPLLASTKLRDYAIA----YGAEKNVLVVIVELN----GLFE-ENSLNFNQLRGDEKT 1295

Human   783 SVIPTPTCDSPQMTAPSLDDDGWATVGVVIIAVVCCVV-------GTSLVWVVIIYHTRRRNEDC 840
            ..|.... |:........||...|.:...:.....|:.       .::|:|        .|:
pombe  1296 LAISEKN-DNMSFVQDLPDDSSLARMNREVSPPKGCIAMVFTDIKNSTLLW--------ERH--- 1348

Human   841 SITNTDETNLPADIPSYLSSQGTLADRQ----DGYVSSESGSHHQFVTSSGAGFFLPQHDSSGTC 901
                      |..:.|.:.:..|:..||    .||.          |.:.|..|.:        |
pombe  1349 ----------PIAMRSAIKTHNTIMRRQLRATGGYE----------VKTEGDAFMV--------C 1385

Human   902 HIDNSSEADVEAATDLFLC-----PFLGSTGPMYLKGNVYG----SDPFETYHTGCSP------- 950
            .      ..|.||  |..|     ..|.:..|..:..:|.|    ....|..:.|.|.
pombe  1386 F------QTVPAA--LLWCFSVQLQLLSADWPNEIVESVQGRLVLGSKNEVLYRGLSVRIGVNYG 1442

Human   951 ------DPRTVLMDHYEP 962
                  ||.|..||:|.|
pombe  1443 VTVSELDPITRRMDYYGP 1460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRIG3	NP_700356.2	LRR	20..395	CDD:227223	101/464 (22%)
		leucine-rich repeat	58..74	CDD:275378	5/15 (33%)
		LRR_RI	<65..>245	CDD:238064	64/296 (22%)
		LRR 1	75..96		4/24 (17%)
		leucine-rich repeat	78..99	CDD:275378	6/26 (23%)
		LRR 2	99..120		7/20 (35%)
		leucine-rich repeat	100..115	CDD:275378	5/14 (36%)
		LRR 3	122..142		7/19 (37%)
		leucine-rich repeat	123..146	CDD:275378	7/22 (32%)
		LRR 4	146..167		7/20 (35%)
		leucine-rich repeat	147..168	CDD:275380	8/21 (38%)
		LRR 5	168..189		12/104 (12%)
		leucine-rich repeat	169..192	CDD:275380	13/106 (12%)
		LRR 6	193..214		7/46 (15%)
		leucine-rich repeat	194..216	CDD:275380	8/47 (17%)
		LRR 7	216..237		7/20 (35%)
		leucine-rich repeat	217..240	CDD:275380	8/22 (36%)
		LRR 8	240..261		4/20 (20%)
		leucine-rich repeat	241..264	CDD:275380	4/28 (14%)
		LRR_RI	262..>446	CDD:238064	45/193 (23%)
		LRR 9	264..285		2/20 (10%)
		leucine-rich repeat	265..288	CDD:275380	2/22 (9%)
		LRR 10	288..309		5/20 (25%)
		leucine-rich repeat	289..312	CDD:275380	6/22 (27%)
		LRR 11	312..333		6/20 (30%)
		leucine-rich repeat	313..336	CDD:275380	6/22 (27%)
		LRR 12	336..357		3/20 (15%)
		leucine-rich repeat	337..360	CDD:275380	3/22 (14%)
		LRR 13	360..382		7/26 (27%)
		leucine-rich repeat	361..385	CDD:275380	8/23 (35%)
		LRR_8	387..442	CDD:290566	15/59 (25%)
		LRR 14	387..408		6/25 (24%)
		leucine-rich repeat	388..411	CDD:275380	8/27 (30%)
		LRR 15	411..432		7/20 (35%)
		leucine-rich repeat	412..435	CDD:275380	7/22 (32%)
		LRRCT	446..494	CDD:214507	13/62 (21%)
		Ig_3	498..585	CDD:290638	20/90 (22%)
		I-set	499..599	CDD:254352	22/103 (21%)
		I-set	603..693	CDD:254352	21/122 (17%)
		Ig_1	620..694	CDD:143240	18/106 (17%)
		I-set	697..784	CDD:254352	19/86 (22%)
		IGc2	711..774	CDD:197706	13/62 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1073..1093
cyr1	NP_596159.1	Ad_cyc_g-alpha	155..200	CDD:129025
		UBQ	292..387	CDD:294102
		leucine-rich repeat	409..430	CDD:275380
		leucine-rich repeat	431..454	CDD:275380
		LRR_RI	<441..616	CDD:238064	43/160 (27%)
		leucine-rich repeat	455..477	CDD:275380	6/20 (30%)
		LRR_8	476..537	CDD:290566	18/60 (30%)
		leucine-rich repeat	478..503	CDD:275380	5/24 (21%)
		leucine-rich repeat	504..526	CDD:275380	6/21 (29%)
		leucine-rich repeat	527..549	CDD:275380	7/22 (32%)
		LRR_8	548..607	CDD:290566	16/58 (28%)
		leucine-rich repeat	550..572	CDD:275380	8/21 (38%)
		leucine-rich repeat	573..596	CDD:275380	8/22 (36%)
		leucine-rich repeat	597..618	CDD:275380	0/20 (0%)
		leucine-rich repeat	661..684	CDD:275380	5/22 (23%)
		leucine-rich repeat	685..707	CDD:275380	3/21 (14%)
		leucine-rich repeat	708..730	CDD:275380	4/21 (19%)
		LRR_RI	<724..941	CDD:238064	58/235 (25%)
		leucine-rich repeat	754..783	CDD:275380	4/28 (14%)
		leucine-rich repeat	784..807	CDD:275380	2/22 (9%)
		leucine-rich repeat	808..831	CDD:275380	6/22 (27%)
		LRR_8	832..889	CDD:290566	16/62 (26%)
		leucine-rich repeat	832..855	CDD:275380	6/22 (27%)
		leucine-rich repeat	856..877	CDD:275380	5/26 (19%)
		leucine-rich repeat	879..901	CDD:275380	8/25 (32%)
		leucine-rich repeat	902..930	CDD:275380	8/27 (30%)
		PP2C	1032..1268	CDD:278884	52/277 (19%)
		CYCc	1300..1488	CDD:214485	38/209 (18%)
		Nucleotidyl_cyc_III	1323..1519	CDD:299850	34/185 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910