DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRIG3 and cdc11

DIOPT Version :9

Sequence 1:NP_700356.2 Gene:LRIG3 / 121227 HGNCID:30991 Length:1119 Species:Homo sapiens
Sequence 2:NP_588419.1 Gene:cdc11 / 2539149 PomBaseID:SPCC1739.11c Length:1045 Species:Schizosaccharomyces pombe


Alignment Length:555 Identity:129/555 - (23%)
Similarity:217/555 - (39%) Gaps:160/555 - (28%)


- Green bases have known domain annotations that are detailed below.


Human    31 GRGELGQP-------SGV--AAERPCPTTCRCLGDLLDCSRKRLARL---PEPL-PSW--VARLD 80
            ||.|.|.|       ||:  .|::....:       ...||:.:.::   .||. |.|  :.:||
pombe   552 GRYENGSPIPFISSGSGLKSKADKDAEYS-------FSVSRQSIIQILSDVEPYEPFWKRIIQLD 609

Human    81 LSHNRL-SFIKASSMSHLQSLREVKLNNNELE-------TIPNLGPVSANITLLSLAGNRIVEIL 137
            :|...| |.|..|.:  ..|:.|:.|..||:.       ||.:|..|...::.|:...|.:    
pombe   610 ISRRHLDSLIGLSEL--CPSIEELTLEGNEIAYLTGCPVTIRDLNAVENRLSSLTSFSNLL---- 668

Human   138 PEHLKEFQSLETLDLSSNNISELQTAFPALQLKYLYLNSNRVTSMEPGYFDNLANTLLVLKLN-- 200
                    :|:.||:|.|.:.:|......:.|:.|.::||.:.|:     |.:.:...:|||:  
pombe   669 --------NLQYLDISYNQLEDLTGLSSLIHLRELKVDSNHLWSL-----DGIQHLDGLLKLSAC 720

Human   201 RNRISAIPPKMFKLPQLQHLELNRNKIKNVDGLTFQGLGALKSLKMQRNGVTKLMDGAFWGLSNM 265
            .|||..:......|.:|:.|.|..|:|:.::.::                          .|.|:
pombe   721 NNRIKELSFTNSNLHRLEELLLGNNEIEEIEEIS--------------------------SLQNL 759

Human   266 EILQLDHNNLTEITKGWLYGLLMLQELHLSQNAINRISPDAWEFCQKLSELDLT-FN------HL 323
            .:||||:|.||.:...  ..::.|:.|.:|.|||:::..|.:...:.| .:||. ||      .|
pombe   760 MVLQLDNNKLTNLKAS--QPMIHLRILRISNNAIHQLEVDQFPHLRTL-YMDLNRFNRPPDIRRL 821

Human   324 SRLDDSSF-----------LGLSL-LNTLHIGNNRVSYIA-DC--AFRG---------------- 357
            .||.:.||           :..|| :..|::.||  :::. ||  .|.|                
pombe   822 KRLVNFSFRTQDPEASNFVIQPSLDIRNLYLSNN--TFVTLDCKHMFLGVRYLELANVQLKEVPK 884

Human   358 -----LSSLKTLDLKNNEISWTIEDMNGAFSGLDKLRRLILQGNRIRSITK--KAFTGLDALEHL 415
                 :.:|:.|||.:|.|| .||.:    ..|..:.||.|.||||:.:..  .....|..|..|
pombe   885 YIATSMPNLRVLDLSHNYIS-DIESL----KPLQMIHRLYLVGNRIKKMRNLCDILANLKQLNVL 944

Human   416 DLS------------DNAIMSLQGNAFSQMKKLQQLHLNTSSLLCDCQLKWLPQWVAENN----- 463
            ||.            |::|..|...:..|....|:.|....    |.|.:|..:.:|.::     
pombe   945 DLRMNPLNFNIYPVIDDSIYELSAASKYQQSINQKGHHRKE----DPQKQWQEKELAFSSTLSEA 1005

Human   464 -------FQSFVNASCAHPQLLKGRSIFAVSPDGF 491
                   :...:..:|.|.:.|.|..:...|...|
pombe  1006 WRTRRKMYAEAILLACPHLEWLDGSDVSQSSRAAF 1040

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRIG3NP_700356.2 LRR 20..395 CDD:227223 104/431 (24%)
leucine-rich repeat 58..74 CDD:275378 4/19 (21%)
LRR_RI <65..>245 CDD:238064 46/195 (24%)
LRR 1 75..96 8/23 (35%)
leucine-rich repeat 78..99 CDD:275378 7/21 (33%)
LRR 2 99..120 8/27 (30%)
leucine-rich repeat 100..115 CDD:275378 6/21 (29%)
LRR 3 122..142 2/19 (11%)
leucine-rich repeat 123..146 CDD:275378 2/22 (9%)
LRR 4 146..167 6/20 (30%)
leucine-rich repeat 147..168 CDD:275380 6/20 (30%)
LRR 5 168..189 5/20 (25%)
leucine-rich repeat 169..192 CDD:275380 6/22 (27%)
LRR 6 193..214 6/22 (27%)
leucine-rich repeat 194..216 CDD:275380 7/23 (30%)
LRR 7 216..237 5/20 (25%)
leucine-rich repeat 217..240 CDD:275380 5/22 (23%)
LRR 8 240..261 0/20 (0%)
leucine-rich repeat 241..264 CDD:275380 1/22 (5%)
LRR_RI 262..>446 CDD:238064 63/240 (26%)
LRR 9 264..285 8/20 (40%)
leucine-rich repeat 265..288 CDD:275380 7/22 (32%)
LRR 10 288..309 7/20 (35%)
leucine-rich repeat 289..312 CDD:275380 7/22 (32%)
LRR 11 312..333 10/38 (26%)
leucine-rich repeat 313..336 CDD:275380 10/40 (25%)
LRR 12 336..357 7/24 (29%)
leucine-rich repeat 337..360 CDD:275380 7/46 (15%)
LRR 13 360..382 9/21 (43%)
leucine-rich repeat 361..385 CDD:275380 9/23 (39%)
LRR_8 387..442 CDD:290566 18/68 (26%)
LRR 14 387..408 7/22 (32%)
leucine-rich repeat 388..411 CDD:275380 8/24 (33%)
LRR 15 411..432 7/32 (22%)
leucine-rich repeat 412..435 CDD:275380 8/34 (24%)
LRRCT 446..494 CDD:214507 10/58 (17%)
Ig_3 498..585 CDD:290638
I-set 499..599 CDD:254352
I-set 603..693 CDD:254352
Ig_1 620..694 CDD:143240
I-set 697..784 CDD:254352
IGc2 711..774 CDD:197706
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1073..1093
cdc11NP_588419.1 leucine-rich repeat 608..627 CDD:275380 7/20 (35%)
leucine-rich repeat 628..669 CDD:275380 10/52 (19%)
LRR_4 648..688 CDD:289563 11/51 (22%)
LRR_RI 667..952 CDD:238064 81/337 (24%)
LRR_4 669..710 CDD:289563 12/45 (27%)
leucine-rich repeat 670..691 CDD:275380 6/20 (30%)
leucine-rich repeat 714..736 CDD:275380 7/21 (33%)
leucine-rich repeat 737..758 CDD:275380 6/46 (13%)
LRR_8 758..812 CDD:290566 18/56 (32%)
leucine-rich repeat 759..780 CDD:275380 7/22 (32%)
leucine-rich repeat 781..801 CDD:275380 7/19 (37%)
leucine-rich repeat 802..823 CDD:275380 6/21 (29%)
leucine-rich repeat 824..869 CDD:275380 11/46 (24%)
LRR_8 868..925 CDD:290566 16/61 (26%)
leucine-rich repeat 870..892 CDD:275380 0/21 (0%)
LRR_4 891..931 CDD:289563 17/44 (39%)
leucine-rich repeat 893..914 CDD:275380 10/25 (40%)
leucine-rich repeat 915..940 CDD:275380 8/24 (33%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.