|
Human 10 EEDEETLKKLIVRLNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRV 74
||....||||:||| |:|:|||:.|:|||:||||..:::|...:||..:|:|||:|:.......:
Zfish 29 EELSIRLKKLLVRL-NLQDGKQLGTMVQIIEDLLFLSHTEHCVELFADQNVHVPVLLKCSESASI 92
Human 75 ASVQQ------------VGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKML-TVHN 126
.||| |||||||:|:|:||.|:.:|..|. |:|.:..|:.|||:| ..||
Zfish 93 -KVQQPPAPRSMLNAVDVGWSLLCRLMEICPNTLDNLARPV----DYEFIDAHKQILKVLHEYHN 152
Human 127 ASVNLSVIGLKTLDLLLTSGKITLLILDEES-DIFMLIFDAMHSFPANDEVQKLGCKALHVLFER 190
....:.::.|:.|.|:|.||:|.:.:||||. |:|..|.:||.||...:|||..||.||..|.:.
Zfish 153 KDAKMMMVALRALALMLKSGEIKMQVLDEEEWDVFYSILEAMKSFSDREEVQLQGCTALQPLLQT 217
Human 191 VSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVE 255
|||..|.||:|.||:.::|:||..|.|.|.:||..|..|..||.|.:|||.|||..|:|:::...
Zfish 218 VSEYHLAEFIEKKDHEVVLNALGCFMDSENVVLEALKVLIPLADPASNVETLMSKTVKCHSLTCR 282
Human 256 AMKAFPMSERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLT 320
||..:..||.|||..||||.:.|...::::||||.||:..|||...||:||.||.:|||||:.|.
Zfish 283 AMNTWLDSEAIQEAGCCLLWKFTSKGYYDMLVLNGVHKVAVKACVSYPDNATLQTAALSCLSALA 347
Human 321 ETIFLNQDLEEKNENQENDDEGE----------EDKLFWLEACYKALTWHRKNKHVQEAACWALN 375
|.|..|..|:|: .|:|:::|.: |:.|.|.||||.|...|.::..||||||||||
Zfish 348 ECIVQNGGLDEE-WNEEDEEEQKVLVKKEAAQAEEMLIWREACYTAFERHAEDVKVQEAACWALN 411
Human 376 NLLMYQNSLHEKIGDEDGHFPAHREVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKG 440
:||::.|:.:.. :.:|..|.|..:|.:||:||||.:||||:::.|.||::::...|..|||.|
Zfish 412 SLLLHCNTSNNV--ELEGRPPLHTLIMAAMLLHSSSVKVFQAASSTLRTLIQRHCRIRSPLLSNG 474
Human 441 IHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPVQLEAL 505
||.|::|||:||.:|..|.||.||:::.||:|:..|||....::.:||..:|.|.....||||.|
Zfish 475 IHFNIVELMRKHPNSSAVCESACKLIHTLFQGARASLDDGFLILSQILIALKTHNFLPEVQLEGL 539
Human 506 RAILHFIVP---------GMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQK 561
||.|..:.| .:.:....|. .|.::|.||.....|.:.|.||||||.:..||:
Zfish 540 RASLVLLNPDRSLREHGVSVADPDMVDV----SLQVLKNQCVLEGAHTVYLQALNRFISSESIQE 600
Human 562 CGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHL 626
|||.|::::.....|::::..:||:|:|||||||:|.:::|...||||:.:||:||.:......:
Zfish 601 CGLGVLAALADSSGAVDLMCQQGAIDTVLHTLQMFPQERDIHYWGLSLLFHLISKKKLSRMMVPV 665
Human 627 LAKILVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQF 691
||.:||||:.:.|:.:.:..||.|.:..:|...:|.:..|...:|:..||..:..|..:|:....
Zfish 666 LASVLVSSVRKHKEDSVMLLKGLQVVWKLLDTCSSAAVWLQKEAFEKEIFQILRENTADQRRDPL 730
Human 692 LNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSPK 756
..:.|.|.:|:..|..:...:|||||:..:..|.|||:.||||.|:..:..||:.|.|::.:...
Zfish 731 QGMSCLCLSKMVTDGEILYALLERACEDGDVDMAECLIQLGADVNKKTKSDSLLYQACDRGAPLA 795
Human 757 LVELLLNSGSREQDVRKALTISIGKGDSQIISLLLRRLALDVANNSICLGGFCIGKVEPSWLGPL 821
|:|||::||..||.:|.||::.:.:.|...::|:||||.||..|:::|||...||.::.||:..|
Zfish 796 LLELLVSSGVHEQHLRGALSVCVRRSDDPAVTLILRRLGLDHTNSALCLGSVRIGHMKASWISAL 860
Human 822 FPDKTSNLRKQTNI-----ASTLARMVIRYQMKSAVEEGTASGSD----GNFSEDVLSKFDEWTF 877
..::.| :.||. ...|||.:.:.|.|..:...:...|| |.|:::...
Zfish 861 LSERRS---QSTNTHYSSKGQRLARQISQLQRKKGIVGVSRLSSDVSTSGYFTDEESD------- 915
Human 878 IPDSSM---DSVFAQSDDLDSEGSEG---SFLVKKKSNSISVGEFYRDAVLQRCSPNLQRHSNSL 936
||.: ||:....|:|:|:||:| .|::...|..:| |..|.:|.|.: |.::|.
Zfish 916 --DSHISLEDSLVFMFDELESDGSDGPPHGFMLISDSLEVS-----RRPVWRRRSHS--RRTSSE 971
Human 937 G---------PIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISS-LASEREYITSLDLSA 991
| |:..| ::..::|.... |:|.|| :..:::.:..||||.
Zfish 972 GYHGEADPSVPVQKH-----------ANSHNIRGQGF------SESFSSPVVLDKDPVRLLDLSG 1019
Human 992 NELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLK 1056
|||.|:..|:....:...:|:|.:|:|..|.|:.||..||::|:|||.|||..|.....||.||.
Zfish 1020 NELNDLSCLTDLNSLKKLIENLHRLDLSGNNLSQFPSILCQSLRSLTRLDLQGNHLQCLPSELLS 1084
Human 1057 MSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISG 1121
:..:..|:||||.|||.:.|:|.|..|.|::.|||:||::..|..|....::||:|.||||:||.
Zfish 1085 LPALHTLNVSRNCIGPLLQLEPGVCSPALRRLNLSFNQITVCPFQLRSATQRLEELSLEGNQISE 1149
Human 1122 ICSPLRLKELKILNLSKNHISSLSENFLEACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFS 1186
:..||.|.|||:|::|||.:..:|:|||..|.|:|:|.|.:|.::::|.||..:|.:|||.|.|:
Zfish 1150 LSLPLCLAELKVLDVSKNQVKIVSDNFLAECLKMETFIASVNQISSLPHLPSKITTVKLSHNTFT 1214
Human 1187 CIPEAILNLPHLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLH 1251
.:||.::|||.|||:||.:|.:..||||:.|.|:|||||:||||.||.||||...|.|:|:||||
Zfish 1215 RVPEIVINLPCLRSVDMRNNSVGVLPGPSVWLSVNLRELMFSHNLISALDLSGPVYKWARLEKLH 1279
Human 1252 LSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCKAK 1316
||.|:|.||||:||.||:|||||||:|..|||||:|||||..:||||||.|.|..|.||||.|.|
Zfish 1280 LSFNRLTEIPPQIGMLEDLTSLDVSHNEGLRSFPDEMGKLVHLWDLPLDGLQLQLDLKHIGSKTK 1344
Human 1317 DIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDVKDWPIQIR 1381
||||||||||||||||:|||||::|.:||||::|:||||:.::| ...:..|:.::||| :|
Zfish 1345 DIIRFLQQRLKKAVPYHRMKLMVLGGSGSGKSSLIQQLMRLRRS---QWRSDPGVSIRDWP--VR 1404
Human 1382 DKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNIKARASSSP 1446
.|.||:::||||:|:|.||....|||||:.||:||.:||||||.:|:.|:|||||||||.|...|
Zfish 1405 SKDKRNMMLNVWEFSGGEECSGIHPHFMSSRAVYLVLYDLSKGASEIHAIKPWLFNIKAVAGQCP 1469
Human 1447 VILVGTHLDVSDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESDALAKLRKTIINESLNF 1511
||:||||.|:.:|:..:.|:.|:.|||.::.||||||:.|.::|.|||::|.:|||.|..|.:.|
Zfish 1470 VIVVGTHADLCEERHLQECLLKLQKELQSQPGFPAIRENHVLSACEESESLGRLRKAIYRELIGF 1534
Human 1512 KIRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLDENELPHAVHFL 1576
||:.|.|:|||:|||||||||.:|.||...|.:|||:...||:::::|.||||:|.|||||:|||
Zfish 1535 KIQGQPVMGQLVPDCYVELEKRLLQERSCAPADFPVLRHSRLMEILQETQLQLEEGELPHAIHFL 1599
Human 1577 NESGVLLHFQDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKF 1641
:|:|||||| ||.|||.||||::.:|.|:|::|.|::|..|.....||::.|..||||:.|.|.|
Zfish 1600 SEAGVLLHF-DPVLQLKDLYFIDLQWFCRIISQTLSLKSSGPWDSTKGVVQRSTVEKFVEKSRCF 1663
Human 1642 PKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVIELPHCENSEIIIRLYEMPYFPMGFWS 1706
||::|.||||||||||||||...:.||:||||||||||||||||||||:|||||||||||||:|.
Zfish 1664 PKDHMIQYFKLLEKFQIALPFDHDQLLIPSSLSDHRPVIELPHCENSEVIIRLYEMPYFPMGYWP 1728
Human 1707 RLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITVPSCR 1771
|.|:||||:|.::|.|||:||:|||:|||:||||:||.||||||.:..|:.:|.||:|||||..|
Zfish 1729 RQISRLLEVSAFLLYGREKALKPNRIYWRKGIYLSWSAEAYCLVEALTLEENPASFIKITVPCSR 1793
Human 1772 KGCILLGQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEE 1836
||.:|.||||||||||:||||||||..||.|.|||||||||||||:||:..||:||:||:.....
Zfish 1794 KGRVLFGQVVDHIDSLLEEWFPGLLTTDIHGTGETLLKKWALYSFSDGQNCQKMLLEDLLSNTNA 1858
Human 1837 GDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGE 1901
..|||||:.|..|:|||||:|||:|:|.|.:.:|:.::||.|...|::||||.|||||:|.|:.|
Zfish 1859 DGLLVNPEDPSCTLPISQISPDLVLSDQPSSTILDPEQLEMELTAEYMLGDGGFGSVYKAVYKNE 1923
Human 1902 EVAVKIFNKHTSL----RLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQD 1962
||||||||||.|. ||:||||.||..|.||||:.|||||..|.:||||||..||||.|.:::
Zfish 1924 EVAVKIFNKHASALYVHRLVRQELAVLGRLCHPSLVGLLAAGCNPHILVMELAPYGSLDSLFERE 1988
Human 1963 KASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRM 2027
..||:|.|||||||||||||:||||:|||||||||||||||.|..:|.|:|||.|||||||||.|
Zfish 1989 NGSLSRKLQHRIALHVADGLKYLHSSMIIYRDLKPHNVLLFNLKTDAEIVAKITDYGIAQYCCSM 2053
Human 2028 GIKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQGKL 2092
|:::||||||||||||||||||||.|||||||||||||:||.|.||.:|:|||:||||:.:||||
Zfish 2054 GVRSSEGTPGFRAPEVARGNVIYNVQADVYSFGLLLYDLLTYGERISDGMKFPSEFDEVAVQGKL 2118
Human 2093 PDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVI---VEC 2154
|||||:|||:|||.:|.|:::|::||||:|||||||||.|||||::||.|.: ||: .||
Zfish 2119 PDPVKDYGCSPWPEIESLMRECMRENPQDRPTSAQVFDRLNSAEMLCLMREL----NVVGFPGEC 2179
Human 2155 MVATH-----HNSRNASIWLGCGHTDR--GQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKE 2212
.|.:: :..:|..:|:|.|.:.: |.::.:||.|.|..::|:..|.|||:.::.......
Zfish 2180 FVVSNSGGAANGGKNPHVWIGGGSSSQKLGCVTAVDLETGGSLNQELDRSPILCMVIIRAADSCS 2244
Human 2213 SWIVSGTQSGTLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIFED 2277
.|:|:|::||:|.:::|.:.|..|.|:.:.||||.||.::..:....|::||||||||.|.|:||
Zfish 2245 DWLVAGSESGSLFIMDTINAKVLHRLKSVKDSVTSLYFHTELQHRCLKSYLLVGTADGTLVIYED 2309
Human 2278 KTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTIQKLIETRTSQ 2342
..:|::...|:|.|.:|:|:||||||..|::..||..:|..|||:|..|:.:|.:.:.|:|:...
Zfish 2310 SALKVENGGPVKTLEVGDVNTPLMCLGPSSHPQERRSLWAACGTRIILFTVEFDVCRSIDTKPKP 2374
Human 2343 LFSYAA--FSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFL-----REVMVKE 2400
|||..| ..::.|..:.||..:|::|.....|||||||||::..||||:..| |:..|..
Zfish 2375 LFSLQARVSGEACISRLAVDKHVYVSKTGGHTVEVWDKKTERMVNLIDCMQLLGLSSTRKPKVHS 2439
Human 2401 NKESKHKMSYSGRVKTLCLQKNTALWIGTGGGHILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGS 2465
..:|: .|..|..||.|.:|.:..|||||..|||||:::|:..|::.|...|:|:|.|.:..|.:
Zfish 2440 EDQSR-PMVPSLVVKALLVQHSGTLWIGTRAGHILLVEVSSCHLLQTINPHCHSIRCMGSILLDT 2503
Human 2466 L--KNVMLVLGYNRK-NTEGTQKQKE--IQSCLT----VWDINLPH 2502
| |||:||||..:: :.|..:.|.| :.|.|: .|.|: ||
Zfish 2504 LNRKNVILVLGRRQRIHLEQLKTQSEGFLVSTLSHQNRTWTIH-PH 2548
|