DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment LRRK2 and Gycalpha99B

DIOPT Version :9

Sequence 1:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens
Sequence 2:NP_477088.2 Gene:Gycalpha99B / 43493 FlyBaseID:FBgn0013972 Length:676 Species:Drosophila melanogaster


Alignment Length:599 Identity:115/599 - (19%)
Similarity:202/599 - (33%) Gaps:223/599 - (37%)


- Green bases have known domain annotations that are detailed below.


Human   217 DEEEI------VLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAMKAFPMSERIQEVSCCLLH 275
            ::||:      :.|:...:..|..|.|  |.|   |....::|.:..:.:|...:::      |.
  Fly    29 EDEELSDDALTLTHLQMAIQLLTAPSN--EDL---NTAVTSLVAKYRQNWPNIHKLK------LD 82

Human   276 RLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISAL-------SCLALLTETIF--LNQDLEE 331
            ..|..:..|...|.::.|.::|    ..|.:|.:|..|       .|...:.|..|  |..||:|
  Fly    83 PQTFKSCANYDYLADIQELLLK----MDEASASEILVLLGEELITCCCTGIIERAFRCLGTDLQE 143

Human   332 ------------KNENQENDDEG-------------EEDKLFW-LEACYKALTWHRKNKHVQEAA 370
                        |.:.::..|.|             |...:.| |....||||            
  Fly   144 FLGSLDGVYDVLKLQEEDVTDTGFVCAGEGELIFTSERPVIAWLLLGSLKALT------------ 196

Human   371 CWALNNLLMYQNSLHEKIGDEDGHFPAHR----------EVMLSMLMHSSSK---EVFQASANAL 422
                  .::|:..::.||...:|....:|          :.||.....|.||   |..|.|.::.
  Fly   197 ------RMLYKVDVNIKIEPVEGDARRYRYLFSLVKDNSQTMLMGRPTSVSKTIPETVQRSNSSN 255

Human   423 STLLEQN-VNFRKILLSKGIHLNVLELMQ-----KHIHSPEVAESGCKMLNHLFEGSNTSLDIMA 481
            ::.|:.| .:|.|:.....|....|||:|     ..::.|.:|:.||:        :.|..|...
  Fly   256 ASDLQMNSSSFCKMFPWHFIMNEQLELVQLGRGFSKLYKPYMADFGCQ--------ATTYFDFKR 312

Human   482 AVVPKILTVMKR---HETSLP----------------VQLEALRAILH--------FIVPGMP-- 517
               ||.||:..|   ..|..|                :.||....::|        ||  |.|  
  Fly   313 ---PKGLTMKFRDIVRRTYTPFLIGLNNPPGAVDFPAIGLEIKGQMVHCPESNSLLFI--GSPFL 372

Human   518 -----------------------------EESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRF 553
                                         |::|.......:::.:     ||.|.:         
  Fly   373 DGLDGLTCNGLFISDIPLHDATREVILVGEQARAQDGLRRRMDKI-----KNSIEE--------- 423

Human   554 IGNPGIQKCGLKVISSIVH--FP-DALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGY--L 613
             .|..:.|...|.: |::|  || :..|.|.|..::|:     :.|||   :..|...::|:  :
  Fly   424 -ANSAVTKERKKNV-SLLHLIFPAEIAEKLWLGSSIDA-----KTYPD---VTILFSDIVGFTSI 478

Human   614 ITKKNVFIGTGHLLAKILVSSLYR-------FKDVAEIQTKGFQTILA----------------- 654
            .::...|      :...::..||:       |.||.:::|.|....:|                 
  Fly   479 CSRATPF------MVISMLEGLYKDFDEFCDFFDVYKVETIGDAYCVASGLHRASIYDAHKVAWM 537

Human   655 ILKLSASFSKLLVH 668
            .||:..:.||.:.|
  Fly   538 ALKMIDACSKHITH 551

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969 115/599 (19%)
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 1012..>1286 CDD:227223
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1084 CDD:275380
LRR 4 1059..1080
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1150
leucine-rich repeat 1131..1174 CDD:275380
LRR 8 1174..1196
leucine-rich repeat 1175..1197 CDD:275380
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1241
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
leucine-rich repeat 1247..1269 CDD:275380
LRR 12 1269..1291
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Gycalpha99BNP_477088.2 HNOB 76..208 CDD:285002 28/159 (18%)
HNOBA 259..451 CDD:285003 42/220 (19%)
CYCc 430..619 CDD:214485 29/137 (21%)
Guanylate_cyc 457..647 CDD:278633 20/109 (18%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

Return to query results.
Submit another query.