| Sequence 1: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_650551.1 | Gene: | Gyc89Db / 42002 | FlyBaseID: | FBgn0038436 | Length: | 669 | Species: | Drosophila melanogaster |
| Alignment Length: | 636 | Identity: | 119/636 - (18%) |
|---|---|---|---|
| Similarity: | 212/636 - (33%) | Gaps: | 247/636 - (38%) |
- Green bases have known domain annotations that are detailed below.
|
Human 41 DLLVFTYSERASKLFQGKNIHVPLLIVLDSYMRVASVQQVGWSLLCKLIEVC----PG-TMQSLM 100
Human 101 G-----------PQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILD 154
Human 155 EESDIFMLIFDAMHSFPANDEVQKLGCKALHVLFER------VSEEQLTEFVENKDYMILLSALT 213
Human 214 NFKDE--------EEIVLHVLHCLHSLAIPCNNVEVLMSGNVRCYNIVVEAM--KAFPMSERIQE 268
Human 269 VSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQISALSCLALLTETIFLNQDLEEKN 333
Human 334 ENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNNLLMYQNSLHEKIGDEDGHFPAH 398
Human 399 REVMLSMLMHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESGC 463
Human 464 KMLNHLFEGSNTSLD--IMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEF 526
Human 527 HHKLNMVKKQCFKNDIHKLVLAALNRFIGNPGIQ-KCGLK---VISSIVH--------FPDALEM 579
Human 580 LS-LEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYLITKKNVFI---GTGHL 626 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | 119/636 (19%) | |
| LRR 1 | 983..1004 | ||||
| leucine-rich repeat | 985..1012 | CDD:275380 | |||
| LRR | 1012..>1286 | CDD:227223 | |||
| LRR 2 | 1012..1033 | ||||
| leucine-rich repeat | 1013..1036 | CDD:275380 | |||
| LRR 3 | 1036..1057 | ||||
| leucine-rich repeat | 1037..1084 | CDD:275380 | |||
| LRR 4 | 1059..1080 | ||||
| LRR 5 | 1084..1105 | ||||
| leucine-rich repeat | 1085..1108 | CDD:275380 | |||
| LRR 6 | 1108..1129 | ||||
| leucine-rich repeat | 1109..1130 | CDD:275380 | |||
| LRR 7 | 1130..1150 | ||||
| leucine-rich repeat | 1131..1174 | CDD:275380 | |||
| LRR 8 | 1174..1196 | ||||
| leucine-rich repeat | 1175..1197 | CDD:275380 | |||
| LRR 9 | 1197..1218 | ||||
| leucine-rich repeat | 1198..1221 | CDD:275380 | |||
| LRR 10 | 1221..1241 | ||||
| leucine-rich repeat | 1222..1246 | CDD:275380 | |||
| LRR 11 | 1246..1267 | ||||
| leucine-rich repeat | 1247..1269 | CDD:275380 | |||
| LRR 12 | 1269..1291 | ||||
| RocCOR | 1334..1507 | CDD:206741 | |||
| COR | 1527..1740 | CDD:318343 | |||
| STKc_LRRK2 | 1884..2135 | CDD:270970 | |||
| WD 1 | 2139..2183 | ||||
| WD 2 | 2188..2228 | ||||
| WD 3 | 2233..2276 | ||||
| WD 4 | 2281..2327 | ||||
| WD 5 | 2333..2377 | ||||
| WD 6 | 2402..2438 | ||||
| WD 7 | 2443..2497 | ||||
| Gyc89Db | NP_650551.1 | HNOB | 2..161 | CDD:400167 | |
| HNOBA | 218..479 | CDD:400168 | 77/404 (19%) | ||
| Nucleotidyl_cyc_III | 488..665 | CDD:416391 | 42/222 (19%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG2114 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||