DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LRRK2 and Gyc89Da

DIOPT Version :9

Sequence 1:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens
Sequence 2:	NP_001036718.1	Gene:	Gyc89Da / 42001	FlyBaseID:	FBgn0038435	Length:	667	Species:	Drosophila melanogaster

Alignment Length:	757	Identity:	131/757 - (17%)
Similarity:	248/757 - (32%)	Gaps:	244/757 - (32%)

- Green bases have known domain annotations that are detailed below.

Human  1890 FGSVYRAA--YEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMELA-- 1950
            :|.:|.:.  |..||..|.|:.|             :||:......|.....|.|..|:.::|
  Fly     2 YGMLYESVQHYVQEEYGVDIWRK-------------VCHIIDCKHNSFKTHQIYPDKLMPDIAEA 53

Human  1951 ------------------------SKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMII 1991
                                    |....|::::.........||....:|:.  :|:      .
  Fly    54 LSACTGESFDFCMNFFGRCFVRFFSNFGYDKMIRSTGRYFCDFLQSIDNIHLI--MRF------T 110

Human  1992 YRDLKPHNVLLFTLYPNAAIIA-KIADYGIAQYCCRMGIKTSEGTPGFRAPEVARGNVIYNQQAD 2055
            |..:|..::.|..:..|.|:|. :.:..|:::|.  :|..|          ||||         :
  Fly   111 YPKMKSPSMQLTNMDDNGAVILYRSSRTGMSKYL--IGQMT----------EVAR---------E 154

Human  2056 VYSFGLLLYDILT----TGG-----RIVEG-----LKFPNEFDELEIQGKL------PDPVKE-- 2098
            .|...:..|.|.:    :||     ::.:|     :|:..:||..|...|.      |..:|.
  Fly   155 FYGLEIKAYVIESQNDISGGTAGPIKLTDGPLTVIVKYRLDFDNREYMAKRVNTEAHPSQLKMPT 219

Human  2099 ------YGCAPWPMV-----------EKLIKQCLKENPQERPTS---AQVFDILNSAELVCLTRR 2143
                  ....|:..|           ||:::..:..||...|.|   ..|.|:..     |  ||
  Fly   220 VKLDVFLDLFPFTFVLNHDMKITHAGEKIVETWIMHNPGANPKSFIGTHVMDLFQ-----C--RR 277

Human  2144 ILLPKNVIVECMVATHHNSRNASIW---------------LGCGHTDRGQLSFLDLNTEGYTSEE 2193
               ||:..::              |               :..||......:.|:::.|.|...:
  Fly   278 ---PKDTTID--------------WDTLIQMRAVLFEFELIRTGHNRAAYDAVLNMDFENYDEMD 325

Human  2194 VADSRILCLALVHLPVEKESWIVSGTQSGTLLVINTEDGKKRHT-------------LEKMTDSV 2245
            :.:::.:.||...  ...||..|...:|.....|:...|::|.:             ..|..||:
  Fly   326 LNEAQTMALAKAQ--EFSESHPVDDDESAREDEIDPATGERRSSQGLRSILLKGQMFYIKDVDSL 388

Human  2246 --TC--------------LYCNSFSKQSKQKNFLLVGTAD-GKLAIFEDKTVKLKGAAPLKILNI 2293
              .|              ||.|..:.....:..::.|... .||.|..:|..:..
  Fly   389 IFLCSPLIENLDELHGIGLYLNDLNPHGLSRELVMAGWQHCSKLEIMFEKEEQRS---------- 443

Human  2294 GNVSTPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFTI---QKLIETRTSQLFSYAAFSDSNII 2355
                      .|...|.|....|...|.::........|   .:|.|.:..|     :|.:.::|
  Fly   444 ----------DELEKSLELADSWKRQGDELLYSMIPRPIAERMRLSEEQVCQ-----SFEEVSVI 493

Human  2356 TVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKHKMSYSGRVKTLCLQ 2420
            .:             .|:.|:|:....:.|.:..|:.|.:|....::|......|  :|:|:.:
  Fly   494 FL-------------EVMNVYDEGLNSIQGAMQTVNTLNKVFSALDEEIISPFVY--KVETVGM- 542

Human  2421 KNTALWIGTGGGHILLLDLSTRRLIRVIYNFCN-SVRVMMTAQLGSLKNVMLVLGYNR-KNTEGT 2483
                :::...|..    |::...    ..:.|: ::|||...:...:.:|.:.:|.|. ....|.
  Fly   543 ----VYMAVSGAP----DVNPLH----AEHACDLALRVMKKFKAHDMGDVAIRVGINSGPVVAGV 595

Human  2484 QKQKEIQSCLTVWDINLPHEVQNLEK--HIEVRKELAEKMRR 2523
            ..||..:.||....:|....:::...  .|::.|...:|:|:
  Fly   596 VGQKVPRYCLFGDTVNTASRMESSSDPWKIQLSKYTGDKVRQ 637

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380
		LRR 8	1174..1196
		leucine-rich repeat	1175..1197	CDD:275380
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1241
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970	58/315 (18%)
		WD 1	2139..2183		8/58 (14%)
		WD 2	2188..2228		7/39 (18%)
		WD 3	2233..2276		12/72 (17%)
		WD 4	2281..2327		5/45 (11%)
		WD 5	2333..2377		7/43 (16%)
		WD 6	2402..2438		5/35 (14%)
		WD 7	2443..2497		12/55 (22%)
Gyc89Da	NP_001036718.1	HNOB	2..161	CDD:285002	36/200 (18%)
		HNOBA	218..476	CDD:285003	48/303 (16%)
		CYCc	457..643	CDD:214485	37/214 (17%)
		Guanylate_cyc	485..662	CDD:278633	33/186 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900