DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRRK2 and CG14877

DIOPT Version :9

Sequence 1:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens
Sequence 2:NP_650507.1 Gene:CG14877 / 41929 FlyBaseID:FBgn0038380 Length:254 Species:Drosophila melanogaster


Alignment Length:250 Identity:44/250 - (17%)
Similarity:95/250 - (38%) Gaps:62/250 - (24%)


- Green bases have known domain annotations that are detailed below.


Human    57 GKNIHVPLLIVL-DSYMRVASVQQVGWSLLCKLIEVCPGTMQS-LMGPQDVGNDWEVLGVHQLIL 119
            |:|..:..|::| |..|..||:.:|     ..:::|....::| .:.|..:..:|          
  Fly    37 GRNCTIRALVLLPDDNMYQASLPRV-----LPILKVAEQQIRSKSLIPSHIDFEW---------- 86

Human   120 KMLTVHNASVNLSVIGLKTLDLLLTSGKITLLILDEESDIFMLIFDAM--HSFPANDEVQKL--- 179
               ..|:...:.|:..:|.:|.::             .....:||..:  :|..|...:.|.   
  Fly    87 ---LAHDTKCDASLGVIKAMDGII-------------KQCAQVIFGPVCDYSLAAVSRITKYFNS 135

Human   180 -GCKALHVLFERVSEEQLTEFVENKDYMILLSALTNFKDEEEIVLHVL---HCLHSLAIPCNNVE 240
             |...:.|.......||......::.||:|.:.:.:|:...|:.::|:   :..||:.....:.:
  Fly   136 QGTPLISVGGSTYDFEQKKTDCNDEFYMLLRTGMLSFETISELTINVMKRHNWSHSIFYYERDGQ 200

Human   241 VLMSGNVRCYNIVVEAMK----------AFP----MSERIQEVSCCLLHRLTLGN 281
            ..::|...|:.::....|          .||    ::.|.:|:      |..:||
  Fly   201 RSVAGMHTCFLMMKSLGKQMRNENMTFAQFPLEPNLTNRTEEM------RREIGN 249

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969 43/249 (17%)
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 1012..>1286 CDD:227223
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1084 CDD:275380
LRR 4 1059..1080
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1150
leucine-rich repeat 1131..1174 CDD:275380
LRR 8 1174..1196
leucine-rich repeat 1175..1197 CDD:275380
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1241
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
leucine-rich repeat 1247..1269 CDD:275380
LRR 12 1269..1291
RocCOR 1334..1507 CDD:206741
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
CG14877NP_650507.1 Periplasmic_Binding_Protein_Type_1 46..>241 CDD:299141 37/225 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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