DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LRRK2 and CG31183

DIOPT Version :9

Sequence 1:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens
Sequence 2:	NP_001287342.1	Gene:	CG31183 / 41927	FlyBaseID:	FBgn0051183	Length:	1417	Species:	Drosophila melanogaster

Alignment Length:	443	Identity:	104/443 - (23%)
Similarity:	178/443 - (40%)	Gaps:	113/443 - (25%)

- Green bases have known domain annotations that are detailed below.

Human  1824 KILLDDLMKK--AEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLG 1886
            |:.|:|:|.:  ||.|   :......|....||:.  |:..|:   :.:|.|.       :..:.
  Fly   564 KVSLEDVMFRDAAERG---LRGSFHSLVKQSSQLT--LMSEDM---VSINGDR-------QIFIP 613

Human  1887 DGSFGSVYRAAYEGEEVAVK---IFNKHTSL-RLLRQELVVLCHLHHPSLISLLAAGI--RPRML 1945
            .|.|        ...:||:|   :.|....| |.|..||..:..|.|..|:....|.:  |...|
  Fly   614 VGMF--------RKSKVAIKPVEVDNVQGLLTRSLMLELKRMKDLQHDHLVKFYGACLDQRRSFL 670

Human  1946 VMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLHSAMIIYRDLKPH-NVLLFTLYPNA 2009
            :.|...||||..:|:.::..|....:..:...:..|:::|||:     |::.| |:.......::
  Fly   671 LTEYCPKGSLQDILENEQFQLDWMFRLSLMHDIVRGMQFLHSS-----DIRSHGNLKSSNCVVDS 730

Human  2010 AIIAKIADYGI-AQYCCRMGIKTSEGTPG---------FRAPEVARGNVIYN------QQADVYS 2058
            ..:.||.|:|: .....|..:::..|...         :.|||:.|  |.:|      |:.|||:
  Fly   731 RFVLKITDFGLHTLRRTRFDLESDGGNCNSHAYWSKLLWTAPELLR--VEHNRPPEGTQKGDVYA 793

Human  2059 FGLLLYDILTTGGRIVEGL----KFPNEFDELEIQGKLPDPVKEYGCAPW-PMVEK--------- 2109
            ||:::::|.|..|....|.    |.|.|..|| ::|..|..:::    |: |.:|.
  Fly   794 FGIIVHEITTRQGPFYLGRCAYEKSPQEIIEL-VKGYNPHRMQK----PFRPELEPNGDTKADIN 853

Human  2110 -LIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRNASIWLGCGH 2173
             :|::|..|:|.|||.    |:.|.|     :.||.                |..|.:     |:
  Fly   854 GIIRRCWAEDPAERPD----FNTLKS-----MIRRF----------------NKDNET-----GN 888

Human  2174 TDRGQLSFLDL---NTEGYTSEEVAD---SRILCLALVH--LPVEKESWIVSG 2218
            .....|..::|   |.|....|...|   .:..|..|::  ||....:.::||
  Fly   889 IVDNLLKRMELYANNLEELVEERTQDYHEEKKKCEKLLYQLLPQSVAAQLISG 941

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380
		LRR 8	1174..1196
		leucine-rich repeat	1175..1197	CDD:275380
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1241
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970	72/288 (25%)
		WD 1	2139..2183		6/43 (14%)
		WD 2	2188..2228		8/36 (22%)
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
CG31183	NP_001287342.1	PBP1_NPR_like	88..498	CDD:107368
		ANF_receptor	108..473	CDD:279440
		PK_GC-A_B	589..883	CDD:270944	82/350 (23%)
		Pkinase_Tyr	613..877	CDD:285015	73/292 (25%)
		HNOBA	<893..938	CDD:285003	10/44 (23%)
		CYCc	917..1108	CDD:214485	6/25 (24%)
		Guanylate_cyc	944..1130	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900