Sequence 1: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_001262138.1 | Gene: | Ac78C / 40333 | FlyBaseID: | FBgn0024150 | Length: | 1727 | Species: | Drosophila melanogaster |
Alignment Length: | 1363 | Identity: | 227/1363 - (16%) |
---|---|---|---|
Similarity: | 417/1363 - (30%) | Gaps: | 495/1363 - (36%) |
- Green bases have known domain annotations that are detailed below.
Human 477 LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKL---------NM 532
Human 533 V-----KKQCFKND-IH-----KLVLAALNRFIGNPGIQKCGLK-------VISSIVHFPDALEM 579
Human 580 LSLE-----GAMDSVLH-----TLQMYPDDQEI--QCLGLSLIG--YLITKKNV-------FIGT 623
Human 624 GHLLAKILVSSLYRFKDVAEIQTKGFQTIL-AIL------------------KLSASFSKLLVHH 669
Human 670 SFDLVI-------FHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVEC 727
Human 728 LLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVR----KALTISIGKGDSQIIS 788
Human 789 LLL--RRLALDVANNSICL------GGF------------CIG---KVEPSWLG----------- 819
Human 820 ---------PLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEG------------TASGSDGN 863
Human 864 FSEDVLSKFDEWTFIPDSSMDSVFAQSDD----------------LDSE-------------GSE 899
Human 900 GSFLVKKKSNSISVGEFYRDAVLQ--------RCS-PNLQRHSNSLGPIFDHE---DLLKR--KR 950
Human 951 KILSSDDSLR---SSKLQSHMRHSDSISSLASE------------------REYITSLDLSAN-- 992
Human 993 -------ELRD-------------------------------IDALS------QKCCISVHLEHL 1013
Human 1014 EKLE----------LHQN---------------ALTSFPQQLCETLKSLTHLDLHSNKFTSFPSY 1053
Human 1054 LLKMSCIANLDVSRNDI----------------------GPSVVLDPTVKCPTLKQFNLSYNQLS 1096
Human 1097 FVPENLTDVVEKLEQ---LILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESF 1158
Human 1159 SARMNFLA--------------------------AMPFLPPSMTILKL-SQNKFSCIPEAILNLP 1196
Human 1197 ------------------HLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYL 1243
Human 1244 WSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDF 1308
Human 1309 KHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDV 1373
Human 1374 KDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNI 1438
Human 1439 KARASSSPVIL------------------VGTHLDVSDEKQRKACMSKITKELLNKRGFPAIR 1483 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | 115/670 (17%) | |
LRR 1 | 983..1004 | 7/66 (11%) | |||
leucine-rich repeat | 985..1012 | CDD:275380 | 9/72 (13%) | ||
LRR | 1012..>1286 | CDD:227223 | 59/368 (16%) | ||
LRR 2 | 1012..1033 | 6/45 (13%) | |||
leucine-rich repeat | 1013..1036 | CDD:275380 | 6/47 (13%) | ||
LRR 3 | 1036..1057 | 4/20 (20%) | |||
leucine-rich repeat | 1037..1084 | CDD:275380 | 10/68 (15%) | ||
LRR 4 | 1059..1080 | 4/42 (10%) | |||
LRR 5 | 1084..1105 | 5/20 (25%) | |||
leucine-rich repeat | 1085..1108 | CDD:275380 | 5/22 (23%) | ||
LRR 6 | 1108..1129 | 3/23 (13%) | |||
leucine-rich repeat | 1109..1130 | CDD:275380 | 3/23 (13%) | ||
LRR 7 | 1130..1150 | 4/19 (21%) | |||
leucine-rich repeat | 1131..1174 | CDD:275380 | 10/68 (15%) | ||
LRR 8 | 1174..1196 | 5/22 (23%) | |||
leucine-rich repeat | 1175..1197 | CDD:275380 | 6/40 (15%) | ||
LRR 9 | 1197..1218 | 3/20 (15%) | |||
leucine-rich repeat | 1198..1221 | CDD:275380 | 4/22 (18%) | ||
LRR 10 | 1221..1241 | 4/19 (21%) | |||
leucine-rich repeat | 1222..1246 | CDD:275380 | 6/23 (26%) | ||
LRR 11 | 1246..1267 | 4/20 (20%) | |||
leucine-rich repeat | 1247..1269 | CDD:275380 | 4/21 (19%) | ||
LRR 12 | 1269..1291 | 4/21 (19%) | |||
RocCOR | 1334..1507 | CDD:206741 | 28/168 (17%) | ||
COR | 1527..1740 | CDD:318343 | |||
STKc_LRRK2 | 1884..2135 | CDD:270970 | |||
WD 1 | 2139..2183 | ||||
WD 2 | 2188..2228 | ||||
WD 3 | 2233..2276 | ||||
WD 4 | 2281..2327 | ||||
WD 5 | 2333..2377 | ||||
WD 6 | 2402..2438 | ||||
WD 7 | 2443..2497 | ||||
Ac78C | NP_001262138.1 | AC_N | <288..551 | CDD:292831 | 44/239 (18%) |
CYCc | 526..729 | CDD:214485 | 38/220 (17%) | ||
Guanylate_cyc | 566..753 | CDD:278633 | 36/204 (18%) | ||
DUF1053 | 929..1020 | CDD:283888 | 16/90 (18%) | ||
CYCc | 1353..1554 | CDD:214485 | 46/265 (17%) | ||
Guanylate_cyc | 1381..1576 | CDD:278633 | 39/242 (16%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG2114 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 0 | 0.000 | Not matched by this tool. | |||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.900 |