DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRRK2 and Ac78C

DIOPT Version :9

Sequence 1:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens
Sequence 2:NP_001262138.1 Gene:Ac78C / 40333 FlyBaseID:FBgn0024150 Length:1727 Species:Drosophila melanogaster


Alignment Length:1363 Identity:227/1363 - (16%)
Similarity:417/1363 - (30%) Gaps:495/1363 - (36%)


- Green bases have known domain annotations that are detailed below.


Human   477 LDIMAAVVPKILTVMKRHETSLPVQLEALRAILHFIVPGMPEESREDTEFHHKL---------NM 532
            :|.:..:|...:.:|:|.|..                   |.||.:.|.....:         ||
  Fly   334 VDFVLKIVLAFVWIMRRSELG-------------------PIESDDGTSMATAITWSVCCGIANM 379

Human   533 V-----KKQCFKND-IH-----KLVLAALNRFIGNPGIQKCGLK-------VISSIVHFPDALEM 579
            .     ..:||.|: :|     ..||..:..|:|    |..|..       .|..::..|.|:..
  Fly   380 AICFLGYWRCFANNYLHWAAVCTWVLFNIQGFVG----QGVGFADREYLVWYILFVIFVPYAMLP 440

Human   580 LSLE-----GAMDSVLH-----TLQMYPDDQEI--QCLGLSLIG--YLITKKNV-------FIGT 623
            |.|:     |.:.:..|     .:::...:..|  :|:...:..  .|.|..||       ....
  Fly   441 LPLKWCVVGGTITASCHLAVITIIKLQHGEATINPECVLFQIFANFILYTAINVAGMYTKYLTDR 505

Human   624 GHLLAKILVSSLYRFKDVAEIQTKGFQTIL-AIL------------------KLSASFSKLLVHH 669
            |..||.|........|..:|.:.:..|.:| :||                  .:...|:||.|:.
  Fly   506 GQRLAFIETHKAMEHKKESEKELQRTQKLLDSILPNIVNNQIRSEMYKGTDPTVETQFNKLYVYP 570

Human   670 SFDLVI-------FHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLKNVMLERACDQNNSIMVEC 727
            ..::.|       |.:::|....|:..:.||.....|.::|.|::...|.|...|       ..|
  Fly   571 MDNVSILFADIKGFTELASKTSAQQLVKILNDLFARFDRIAEDNHCLRVKLLGDC-------YYC 628

Human   728 LLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSREQDVR----KALTISIGKGDSQIIS 788
            :....:|..:.:...:    ||..|:...:::.:       :|||    ..|.:.||.....::.
  Fly   629 VSQFESDNWKTRPDHA----VCSVETGLHMIKAI-------KDVRLHTHVDLNMRIGIHSGSVMC 682

Human   789 LLL--RRLALDVANNSICL------GGF------------CIG---KVEPSWLG----------- 819
            .:|  ::...||.:|.:.:      ||.            |:.   :|||...|           
  Fly   683 GVLGNKKWHFDVWSNDVIIANHMESGGIPGRVHISEATLKCLNDAYEVEPGNGGCRDNHLKMLNV 747

Human   820 ---------PLFPDKTSNLRKQTNIASTLARMVIRYQMKSAVEEG------------TASGSDGN 863
                     ||.|.:....|...::|.::|.........:|:.:.            ||:|:||.
  Fly   748 KTYLIKRTEPLRPKRRFGTRSSAHLAGSVATAAPPCATPTALPKSISASGSGSIGGVTATGNDGA 812

Human   864 FSEDVLSKFDEWTFIPDSSMDSVFAQSDD----------------LDSE-------------GSE 899
            ..:....::.....:|......:..|...                :||.             |:.
  Fly   813 SIDGRSLEYAATIAVPAQQPTQLLQQQQKKNISLNSLPNVVEGVAMDSRRIRNGCGVMGGAGGTG 877

Human   900 GSFLVKKKSNSISVGEFYRDAVLQ--------RCS-PNLQRHSNSLGPIFDHE---DLLKR--KR 950
            |........:::|.......|.|:        .|| .||....:..|.|.:.|   |.:..  .:
  Fly   878 GGGTGPCGMSTVSSPTAMMSAPLEVQLRPRNGACSIQNLAEAIDGKGLIIEDESTTDWIPEIPFK 942

Human   951 KILSSDDSLR---SSKLQSHMRHSDSISSLASE------------------REYITSLDLSAN-- 992
            .:.|.:|.|.   |..:.:...|..|::.|..|                  |||:....|...  
  Fly   943 NLNSPEDGLNRADSILVDTKEDHRVSVAVLDEEIDEFIEQNIQINSNKEIRREYLNPWTLKFKDK 1007

Human   993 -------ELRD-------------------------------IDALS------QKCCISVHLEHL 1013
                   :||:                               |..||      ..||:.|..|..
  Fly  1008 SQEQKFCQLREDMFRSNMLCVFVIWIFMVLCQVIIIPRCTRLIICLSVGTVILTFCCVLVMAEEF 1072

Human  1014 EKLE----------LHQN---------------ALTSFPQQLCETLKSLTHLDLHSNKFTSFPSY 1053
            ..|.          :||.               .|::....||.:...:...|.||.       :
  Fly  1073 PGLPRCLKTNSAKLVHQRQRRTLFICGVIVSMCMLSAIGLVLCPSSTYIGTADEHSR-------F 1130

Human  1054 LLKMSCIANLDVSRNDI----------------------GPSVVLDPTVKCPTLKQFNLSYNQLS 1096
            |..:|..:|:.::..:.                      ||:.::|.|...|:.:....:.|.|:
  Fly  1131 LRMVSPYSNISMTEKEFKLNVYLSATIHHNITISTPASGGPTPLVDITSSGPSDEFVRSTLNALT 1195

Human  1097 FVPENLTDVVEKLEQ---LILEGNKISGICSPLRLKELKILNLSKNHISSLSENFLEACPKVESF 1158
            .   |||..:.:..:   |...|:.:|            :.|||.:..|     .:::...||..
  Fly  1196 L---NLTPPLPQSHRPYTLTTNGHSVS------------LSNLSYSDAS-----VMQSSSDVEGQ 1240

Human  1159 SARMNFLA--------------------------AMPFLPPSMTILKL-SQNKFSCIPEAILNLP 1196
            .|...:|.                          ||.....::.::|. |.:.||.:..:.|.:|
  Fly  1241 CAHPEYLVFTWVLCLVSLATALKLYYLVKALMALAMVAFYTTLIMMKFGSGDSFSLVELSRLGMP 1305

Human  1197 ------------------HLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISILDLSEKAYL 1243
                              |.|.::::|. :.::     ||....|||....:..::.|...|..|
  Fly  1306 LGVQMLILLISFLVMVCYHARLVEVTSR-LDFI-----WKEQAERELTNMKSNRALNDTLIKNIL 1364

Human  1244 WSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDF 1308
            ...|...:||.....|:..:   :.||..:..:.....:.|.:|.....|.....|:|:..:|| 
  Fly  1365 PDHVATYYLSDEHTDELYSK---MHNLCGVMFASIPNFQDFYSEDIDNGKACIRILNEIICDFD- 1425

Human  1309 KHIGCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMKTKKSDLGMQSATVGIDV 1373
                       ..|::....:|.    |:..||.|                     ..|..|::.
  Fly  1426 -----------ELLEEPRFASVE----KIKTVGAT---------------------YMAAAGLNH 1454

Human  1374 KDWPIQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMKPWLFNI 1438
            :.  :::|.:...|.|.::.:||           |..::.|         .:...||...  |.:
  Fly  1455 EH--LRLRGETSEDSVCDLVEFA-----------FAMKQKL---------EEINGDAFNN--FQL 1495

Human  1439 KARASSSPVIL------------------VGTHLDVSDEKQRKACMSKITKELLNKRGFPAIR 1483
            :....|.|::.                  |.:.:|.:.|..| ..:.:.|.|||..||:..::
  Fly  1496 RVGICSGPLVSGVIGARKPVYDIWGNTVNVASRMDSTGENWR-VQVPENTAELLCSRGYTCVK 1557

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969 115/670 (17%)
LRR 1 983..1004 7/66 (11%)
leucine-rich repeat 985..1012 CDD:275380 9/72 (13%)
LRR 1012..>1286 CDD:227223 59/368 (16%)
LRR 2 1012..1033 6/45 (13%)
leucine-rich repeat 1013..1036 CDD:275380 6/47 (13%)
LRR 3 1036..1057 4/20 (20%)
leucine-rich repeat 1037..1084 CDD:275380 10/68 (15%)
LRR 4 1059..1080 4/42 (10%)
LRR 5 1084..1105 5/20 (25%)
leucine-rich repeat 1085..1108 CDD:275380 5/22 (23%)
LRR 6 1108..1129 3/23 (13%)
leucine-rich repeat 1109..1130 CDD:275380 3/23 (13%)
LRR 7 1130..1150 4/19 (21%)
leucine-rich repeat 1131..1174 CDD:275380 10/68 (15%)
LRR 8 1174..1196 5/22 (23%)
leucine-rich repeat 1175..1197 CDD:275380 6/40 (15%)
LRR 9 1197..1218 3/20 (15%)
leucine-rich repeat 1198..1221 CDD:275380 4/22 (18%)
LRR 10 1221..1241 4/19 (21%)
leucine-rich repeat 1222..1246 CDD:275380 6/23 (26%)
LRR 11 1246..1267 4/20 (20%)
leucine-rich repeat 1247..1269 CDD:275380 4/21 (19%)
LRR 12 1269..1291 4/21 (19%)
RocCOR 1334..1507 CDD:206741 28/168 (17%)
COR 1527..1740 CDD:318343
STKc_LRRK2 1884..2135 CDD:270970
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
Ac78CNP_001262138.1 AC_N <288..551 CDD:292831 44/239 (18%)
CYCc 526..729 CDD:214485 38/220 (17%)
Guanylate_cyc 566..753 CDD:278633 36/204 (18%)
DUF1053 929..1020 CDD:283888 16/90 (18%)
CYCc 1353..1554 CDD:214485 46/265 (17%)
Guanylate_cyc 1381..1576 CDD:278633 39/242 (16%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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