DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRK2 and Ac76E

DIOPT Version :9

Sequence 1:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens
Sequence 2:	NP_001246838.1	Gene:	Ac76E / 40180	FlyBaseID:	FBgn0004852	Length:	1312	Species:	Drosophila melanogaster

Alignment Length:	749	Identity:	141/749 - (18%)
Similarity:	251/749 - (33%)	Gaps:	248/749 - (33%)

- Green bases have known domain annotations that are detailed below.

Human  1823 QKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGD 1887
            |::.|:  .::.::..||::            :.|..|.|::.|:|||.             :.|
  Fly   252 QRVKLE--CEREQQEQLLLS------------VIPAYIAAEVKRSIMLK-------------MAD 289

Human  1888 G---SFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPRMLVMEL 1949
            .   :.|....:|....|:.|:   :||::.:|..::|...    |...||.|:.     ||..|
  Fly   290 ACQRAGGQASTSATRFHELHVQ---RHTNVTILFADIVNFT----PLSSSLTASD-----LVKTL 342

Human  1950 ASK-GSLDRLLQQDKASLTRTL---------------QH-----RIALHVADGLRYLHSAMIIYR 1993
            ... |..|::.|:::....:.|               ||     .:.|.:.|.:|::..|..|..
  Fly   343 NDLFGRFDQIAQENQCLRIKILGDCYYCVSGLPISRPQHATNCVNMGLQMIDAIRHVREATGINV 407

Human  1994 DLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSE---GTPGFRAPEVARGNVIYNQQAD 2055
            |:                              |:||.|..   |..|.|           ..|.|
  Fly   408 DM------------------------------RIGIHTGNVLCGVLGLR-----------KWQFD 431

Human  2056 VYSFGLLLYDILTTGGRIVEG--------LKFPNEFDELEIQGK-------LPD-PVKEYGCAP- 2103
            |:|..:.|.:.:.:||  |.|        |.|..:..|:| ||:       |.| .|:.|...|
  Fly   432 VWSDDVTLANHMESGG--VAGRVHITKQTLDFLGDKFEVE-QGEGGNRDAYLADHKVESYLIVPP 493

Human  2104 ---WPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL--------VCLTRRILLPKNVIVECMVA 2157
               :......:.:|:::| ...||:.:..:|..:.:.        |.|...:..|..::.|.|..
  Fly   494 KPAYTYSVPRVVECIEQN-DPSPTTEETKEIKETDQSHEATDVADVLLPVTVAPPPAIVDEKMSP 557

Human  2158 THHNSRNASIWLGCGHTDRGQLSFLDLNTEGYTSEEVADSRILCLALVHLPVEKESWIVSGTQSG 2222
            |..||:.|.:     |......:.:.:.......:|..::..:...|:|
  Fly   558 TSINSQEAPL-----HAPLASAASMSIKELSEEEDEADEATAVTEPLMH---------------- 601

Human  2223 TLLVINTEDGKKRHTLEKMTDSVTCLYCNSFSKQSKQKNFLLVGTADGKLAIF-EDKTVKLKGA- 2285
                 ..:|||  :..|...:.......:|.:.:|..|:..|...||..|::. .:..:...||
  Fly   602 -----RDQDGK--NDKEPKANGGHRGSGDSAASESVAKSAALSLPADDLLSMSGSESGISNSGAQ 659

Human  2286 ---------APLKILNIGNVSTPLMCLSESTNSTERNVMWGGCGTKIFSF------SNDFTIQKL 2335
                     .|......|..::..:.::|:...:.|.:...|    :.||      |..|
  Fly   660 AQSSNPASVTPTAAAPAGGAASNSLTVAEAPERSRRKLSVQG----LMSFADRRRSSGAF----- 715

Human  2336 IETRTSQLFSYAAF-SDSNIITVVVDTALYIAKQNSP------VVEVW----------DKKTEKL 2383
            ||.|...:.|..:| |.:..:|           :|.|      .||.|          :.|..|.
  Fly   716 IEGRKLSIHSGESFRSHAGHVT-----------RNRPSSKMTKYVECWGADRPFANIAESKLVKN 769

Human  2384 CGLIDCVHFLREVMVKENKESKHKMSYSG---RVKTLCL-QKNT---ALWIGTGGGH-------- 2433
            .||.........::..|.|  ....::.|   .:|...: .:||   |::......|
  Fly   770 IGLASIAMIESNLLPPERK--CFNFNFFGPPTELKPFTMWYRNTPREAMYRAQPDTHFRFDLICA 832

Human  2434 -ILLLDLSTRRLIRVIYNFCNSVRVMMTAQLGSL 2466
             :|.|.|:..:||.:..|.         |.||||
  Fly   833 FVLFLSLAVVQLIVIELNL---------ALLGSL 857

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380
		LRR 8	1174..1196
		leucine-rich repeat	1175..1197	CDD:275380
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1241
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970	60/297 (20%)
		WD 1	2139..2183		9/43 (21%)
		WD 2	2188..2228		3/39 (8%)
		WD 3	2233..2276		9/43 (21%)
		WD 4	2281..2327		9/61 (15%)
		WD 5	2333..2377		12/60 (20%)
		WD 6	2402..2438		8/51 (16%)
		WD 7	2443..2497		8/24 (33%)
Ac76E	NP_001246838.1	AC_N	<67..289	CDD:292831	11/63 (17%)
		CYCc	259..467	CDD:214485	55/287 (19%)
		Guanylate_cyc	311..469	CDD:278633	42/212 (20%)
		BASP1	510..667	CDD:283191	30/185 (16%)
		CYCc	1079..1283	CDD:214485
		Guanylate_cyc	1101..1305	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900