DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRRK2 and CG42637

DIOPT Version :9

Sequence 1:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens
Sequence 2:NP_001007096.1 Gene:CG42637 / 40153 FlyBaseID:FBgn0261360 Length:1525 Species:Drosophila melanogaster


Alignment Length:963 Identity:171/963 - (17%)
Similarity:327/963 - (33%) Gaps:369/963 - (38%)


- Green bases have known domain annotations that are detailed below.


Human  1376 WP--------IQIRDKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDAMK 1432
            ||        :.:||......||.|...........|........||.:|:.:::|         
  Fly     4 WPFNLLLLLSVAVRDCSNHRTVLTVGYLTALTGDLKTRQGLAISGALTMALDEVNK--------- 59

Human  1433 PWLFNIKARASSSPVILVGTHLDV--SDEKQRKACMSKITKELLNKRGFPAIRDYHFVNATEESD 1495
                        .|.:|...:||:  :|.|......:|...|::                   .|
  Fly    60 ------------DPNLLPNVYLDLRWNDTKGDTVLATKAITEMI-------------------CD 93

Human  1496 ALAKLRKTIINESLNFKIRDQLVVGQLIPD--CYVELEKIILSERKNVPI-----------EFPV 1547
            .:|    ||..                 |:  ||||   .|:|:.:|:|:           ..|.
  Fly    94 GIA----TIFG-----------------PEGPCYVE---AIVSQSRNIPMISYKCAEYRASAIPT 134

Human  1548 IDR---------KRLLQLVR----------------------------------------ENQL- 1562
            ..|         |.||.|:|                                        :|:: 
  Fly   135 FARTEPPDTQVVKSLLALLRYYAWNKFSILYEDVWSPVADLLKDQATKRNMTINHKQSFIDNRVK 199

Human  1563 ---------------QLDENEL--PHAVHFLNESGVLLHFQDPALQLSDLY--------FVE--- 1599
                           ||.:|.:  .....||..:..|:.|.. :::.:.|:        ||:   
  Fly   200 CCEQMLDCCRSGYWYQLVQNTMNRTRIYVFLGAANSLVDFMS-SMETAGLFARGEYMVIFVDMMV 263

Human  1600 ------PKWLCKI-----------------MAQILTVKVEGCPKHPKGIISRRDVEKFLSK---K 1638
                  .|:|.::                 ||:.|.| |...|.....|...:.|:|:.||   .
  Fly   264 YSEREAEKYLRRVDQITFMSNCHSTENFNQMARSLLV-VASTPPTKDYIQFTKQVQKYSSKPPFN 327

Human  1639 RKFPKNYMSQYFKLLEKFQIALPIGEEYL---------LVPSSLSDHRPVIELPHCENSEIIIRL 1694
            .:.|:.::...|   .||   :.|...||         .|...|.:...|:      ..::|..:
  Fly   328 LEIPRLFVESNF---SKF---ISIYAAYLYDSVKLYAWAVDKMLREETRVL------TDDVIFEV 380

Human  1695 YEMPYFPMGFWSRLINRLLEISPYM-LSGRE---------------RALRPNRMYWRQGIYLNWS 1743
                   ....:|:|:.:::...|| ::|.:               .|.:|::......:..|:.
  Fly   381 -------ASNGTRVIDTIIKNRTYMSITGSKIKIDQYGDSEGNFSVLAYKPHKWNNSNNMPCNYH 438

Human  1744 --PEAYCLVGSEVLDNHPESFL---KITVPS-----------------CRK---------GCILL 1777
              |.||...|.|    |||..|   .|..||                 |:|         ..::|
  Fly   439 MVPVAYFHQGEE----HPEYKLINGSIDWPSGGEKPADEPMCGFANELCKKDDTHYTSTVAAVVL 499

Human  1778 GQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVN 1842
            |.::         :..|::.:.|       .:||.:          ::.::.|:.|       ::
  Fly   500 GVLL---------FCSGVITMSI-------YRKWKI----------ELEIEGLLWK-------ID 531

Human  1843 PDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEFLLGDGSF-GSVYRAAYEGEEVAVK 1906
            |::      |...:.:.|::...:..:::..........:|:...|.. |:|.|..      .:|
  Fly   532 PNE------IKGYSGNEIVSSPSKVSLMSAQSYGSRWTNQFVTSTGRLRGAVVRIK------ELK 584

Human  1907 IFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRT 1969
            ...|....|.:.:|:.:|..|.|.::.|.:.|.:.|.  :||.:..:||||..:::.:...|...
  Fly   585 FPRKRDISREIMKEMRLLRELRHDNINSFIGASVEPTRILLVTDYCAKGSLYDIIENEDIKLDDL 649

Human  1970 LQHRIALHVADGLRYLHSAMIIYR-DLKPHNVLLFTLYPNAAIIAKIADYGI--AQYCCR---MG 2028
            ....:...:..|:.|:|::.::|. :||..|.::.:.:     :.::.|:|:  .:.|..   :|
  Fly   650 FIASLIHDLIKGMIYIHNSQLVYHGNLKSSNCVVTSRW-----MLQVTDFGLHELRQCAENESIG 709

Human  2029 IKTSEGTPGFRAPEVARGNVIYNQQADVYSFGLLLYDILTTGG----------RIVEGLKFPNEF 2083
            .........:||||:.|.::..:|:.|||:|.:::|:|.:..|          .||:.:|     
  Fly   710 EHQHYRNQLWRAPELLRNHIHGSQKGDVYAFAIIMYEIFSRKGPFGQINFEPKEIVDYVK----- 769

Human  2084 DELEIQGKLPDPVKEYGCAPWPMVEKL-------------IKQCLKENPQERP 2123
             :|.::|:  ||.:       |.||.:             |:.|..|:|:|||
  Fly   770 -KLPLKGE--DPFR-------PEVESIIEAESCPDYVLACIRDCWAEDPEERP 812

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 1..969
LRR 1 983..1004
leucine-rich repeat 985..1012 CDD:275380
LRR 1012..>1286 CDD:227223
LRR 2 1012..1033
leucine-rich repeat 1013..1036 CDD:275380
LRR 3 1036..1057
leucine-rich repeat 1037..1084 CDD:275380
LRR 4 1059..1080
LRR 5 1084..1105
leucine-rich repeat 1085..1108 CDD:275380
LRR 6 1108..1129
leucine-rich repeat 1109..1130 CDD:275380
LRR 7 1130..1150
leucine-rich repeat 1131..1174 CDD:275380
LRR 8 1174..1196
leucine-rich repeat 1175..1197 CDD:275380
LRR 9 1197..1218
leucine-rich repeat 1198..1221 CDD:275380
LRR 10 1221..1241
leucine-rich repeat 1222..1246 CDD:275380
LRR 11 1246..1267
leucine-rich repeat 1247..1269 CDD:275380
LRR 12 1269..1291
RocCOR 1334..1507 CDD:206741 24/140 (17%)
COR 1527..1740 CDD:318343 56/352 (16%)
STKc_LRRK2 1884..2135 CDD:270970 62/272 (23%)
WD 1 2139..2183
WD 2 2188..2228
WD 3 2233..2276
WD 4 2281..2327
WD 5 2333..2377
WD 6 2402..2438
WD 7 2443..2497
CG42637NP_001007096.1 PBP1_Speract_GC_like 26..445 CDD:107365 80/503 (16%)
ANF_receptor 48..412 CDD:279440 72/448 (16%)
PK_GC-A_B 543..827 CDD:270944 64/296 (22%)
HNOBA <835..881 CDD:285003
CYCc 860..1052 CDD:214485
Guanylate_cyc 887..1074 CDD:278633
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG2114
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.900

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