| Sequence 1: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_729905.2 | Gene: | CG10738 / 39516 | FlyBaseID: | FBgn0036368 | Length: | 1250 | Species: | Drosophila melanogaster |
| Alignment Length: | 625 | Identity: | 126/625 - (20%) |
|---|---|---|---|
| Similarity: | 240/625 - (38%) | Gaps: | 175/625 - (28%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1623 KGIISRR-------DVEKFLSKKRKFPKNYMSQYFKLLEKFQ-IALPIGEEYL-LVPSSLSD--- 1675
Human 1676 ---------HRPVIELPHCENSEIIIRLYEMPYFPMG-----------------FWSRLINRLLE 1714
Human 1715 ISPYMLSGRER-------ALRPNRMYWRQG--IYLNWSPEA---YCL------------------ 1749
Human 1750 -VGSEVLDNH---------PESFLKI---------TVPSCRKGCILLGQVVDHIDSLMEEWFPGL 1795
Human 1796 LEIDICGEGETLLKKWALYSFNDGEEHQKILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLI 1860
Human 1861 LADLPRNI-------MLNNDELEFEQAPEFLLGDGSFGSVYR--AAYEGEEVAVKIFNKHT--SL 1914
Human 1915 RLLRQELVVLCHLHHPSLISLLAAGIRPR--MLVMELASKGSLDRLLQQDKASLTRTLQHRIALH 1977
Human 1978 VAD---GLRYLHSAMIIYRD-LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPG- 2037
Human 2038 ---------FRAPEVARGN----VIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFDELEIQ 2089
Human 2090 GKLPDPVKEYGCAPWPM------VEKLIKQCLKENPQERP 2123 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | ||
| LRR 1 | 983..1004 | ||||
| leucine-rich repeat | 985..1012 | CDD:275380 | |||
| LRR | 1012..>1286 | CDD:227223 | |||
| LRR 2 | 1012..1033 | ||||
| leucine-rich repeat | 1013..1036 | CDD:275380 | |||
| LRR 3 | 1036..1057 | ||||
| leucine-rich repeat | 1037..1084 | CDD:275380 | |||
| LRR 4 | 1059..1080 | ||||
| LRR 5 | 1084..1105 | ||||
| leucine-rich repeat | 1085..1108 | CDD:275380 | |||
| LRR 6 | 1108..1129 | ||||
| leucine-rich repeat | 1109..1130 | CDD:275380 | |||
| LRR 7 | 1130..1150 | ||||
| leucine-rich repeat | 1131..1174 | CDD:275380 | |||
| LRR 8 | 1174..1196 | ||||
| leucine-rich repeat | 1175..1197 | CDD:275380 | |||
| LRR 9 | 1197..1218 | ||||
| leucine-rich repeat | 1198..1221 | CDD:275380 | |||
| LRR 10 | 1221..1241 | ||||
| leucine-rich repeat | 1222..1246 | CDD:275380 | |||
| LRR 11 | 1246..1267 | ||||
| leucine-rich repeat | 1247..1269 | CDD:275380 | |||
| LRR 12 | 1269..1291 | ||||
| RocCOR | 1334..1507 | CDD:206741 | |||
| COR | 1527..1740 | CDD:318343 | 29/163 (18%) | ||
| STKc_LRRK2 | 1884..2135 | CDD:270970 | 66/270 (24%) | ||
| WD 1 | 2139..2183 | ||||
| WD 2 | 2188..2228 | ||||
| WD 3 | 2233..2276 | ||||
| WD 4 | 2281..2327 | ||||
| WD 5 | 2333..2377 | ||||
| WD 6 | 2402..2438 | ||||
| WD 7 | 2443..2497 | ||||
| CG10738 | NP_729905.2 | PBP1_Speract_GC_like | 41..441 | CDD:107365 | 34/198 (17%) |
| ANF_receptor | 67..416 | CDD:279440 | 31/173 (18%) | ||
| PK_GC-A_B | 570..853 | CDD:270944 | 67/284 (24%) | ||
| TyrKc | 597..847 | CDD:197581 | 65/254 (26%) | ||
| HNOBA | <862..907 | CDD:285003 | |||
| CYCc | 886..1078 | CDD:214485 | |||
| Guanylate_cyc | 913..1099 | CDD:278633 | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG2114 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||