Sequence 1: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_620469.2 | Gene: | ACXD / 38284 | FlyBaseID: | FBgn0040507 | Length: | 1162 | Species: | Drosophila melanogaster |
Alignment Length: | 569 | Identity: | 110/569 - (19%) |
---|---|---|---|
Similarity: | 200/569 - (35%) | Gaps: | 184/569 - (32%) |
- Green bases have known domain annotations that are detailed below.
Human 588 SVLHTL---------QMYPDDQEIQC--------LGLSLIGYLITKK------------------ 617
Human 618 ----NVFIGTGH--LLAKI----LVSSLYRFKDVAEIQTKGFQTILAILKLSASFSKLLVHHSFD 672
Human 673 LVI--FHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDYLK------------NVMLERACDQNNSI 723
Human 724 MVECLLLLGADANQAKEGSSLICQVCEKESSPKLVELLLNSGSR-----------------EQDV 771
Human 772 -----------RKALTISIGKGDSQIISLLLRRLALDVANNSI------CLGG--FCI-GKVEPS 816
Human 817 WLGPLFPDKTS-----NLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLS------ 870
Human 871 --KFDEWTFIPDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGE-FYRDAVLQ-RCSPNLQR 931
Human 932 HS------NSL-GPIFDHEDLLKRKRKILSSDDSLRSSKLQSHMRHSDSISSLASEREYITSLD- 988
Human 989 -----------------LSANEL------RDIDALSQKCCISVHLEHLE 1014 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | 99/498 (20%) | |
LRR 1 | 983..1004 | 6/44 (14%) | |||
leucine-rich repeat | 985..1012 | CDD:275380 | 8/50 (16%) | ||
LRR | 1012..>1286 | CDD:227223 | 1/3 (33%) | ||
LRR 2 | 1012..1033 | 1/3 (33%) | |||
leucine-rich repeat | 1013..1036 | CDD:275380 | 1/2 (50%) | ||
LRR 3 | 1036..1057 | ||||
leucine-rich repeat | 1037..1084 | CDD:275380 | |||
LRR 4 | 1059..1080 | ||||
LRR 5 | 1084..1105 | ||||
leucine-rich repeat | 1085..1108 | CDD:275380 | |||
LRR 6 | 1108..1129 | ||||
leucine-rich repeat | 1109..1130 | CDD:275380 | |||
LRR 7 | 1130..1150 | ||||
leucine-rich repeat | 1131..1174 | CDD:275380 | |||
LRR 8 | 1174..1196 | ||||
leucine-rich repeat | 1175..1197 | CDD:275380 | |||
LRR 9 | 1197..1218 | ||||
leucine-rich repeat | 1198..1221 | CDD:275380 | |||
LRR 10 | 1221..1241 | ||||
leucine-rich repeat | 1222..1246 | CDD:275380 | |||
LRR 11 | 1246..1267 | ||||
leucine-rich repeat | 1247..1269 | CDD:275380 | |||
LRR 12 | 1269..1291 | ||||
RocCOR | 1334..1507 | CDD:206741 | |||
COR | 1527..1740 | CDD:318343 | |||
STKc_LRRK2 | 1884..2135 | CDD:270970 | |||
WD 1 | 2139..2183 | ||||
WD 2 | 2188..2228 | ||||
WD 3 | 2233..2276 | ||||
WD 4 | 2281..2327 | ||||
WD 5 | 2333..2377 | ||||
WD 6 | 2402..2438 | ||||
WD 7 | 2443..2497 | ||||
ACXD | NP_620469.2 | AC_N | <42..284 | CDD:292831 | 44/216 (20%) |
CYCc | 254..476 | CDD:214485 | 49/250 (20%) | ||
Nucleotidyl_cyc_III | 321..503 | CDD:299850 | 45/209 (22%) | ||
CYCc | 856..1117 | CDD:214485 | |||
Nucleotidyl_cyc_III | 878..1142 | CDD:299850 | |||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG2114 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 0 | 0.000 | Not matched by this tool. | |||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.900 |