DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment LRRK2 and CG3216

DIOPT Version :9

Sequence 1:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens
Sequence 2:	NP_726013.2	Gene:	CG3216 / 37376	FlyBaseID:	FBgn0034568	Length:	1161	Species:	Drosophila melanogaster

Alignment Length:	472	Identity:	107/472 - (22%)
Similarity:	177/472 - (37%)	Gaps:	160/472 - (33%)

- Green bases have known domain annotations that are detailed below.

Human  1767 VPSCRKGCILLGQVVD---HIDSLMEE-----WFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ 1823
            ||.|.    .||...|   :..::|..     .|.||:.:.||
  Fly   519 VPPCG----FLGNSTDCVGNFSTIMYSVFGLLLFLGLVFLVIC---------------------- 557

Human  1824 KILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLP---------RNIMLNNDELEFEQ 1879
              ||...||.::|           |.....::.||.:|.::.         :.:.:.|..|:
  Fly   558 --LLQKQMKLSKE-----------LNNMSWRVRPDDVLIEMGGMFGSKGGLQRLDVENISLQ--- 606

Human  1880 APEFLLGDG-----SFGS----VYR--AAYEGEEVAVKIFN-KHTSLR-LLRQELVVLCHLHHPS 1931
              :|.:..|     ||.|    ||.  ..::||.||:|..| |...|. .|..|:.....:.|.:
  Fly   607 --QFGIHSGRASIASFTSLPPQVYTTIGQFKGERVAIKKVNVKKVDLTPQLLWEIKQARDVSHEN 669

Human  1932 LISLLAAGI---RPRMLVM-ELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH-SAMII 1991
            .:..:.|.|   ||.:|:: |..|:|||..:|:.:...|....:..:...:..|:.||| |.:..
  Fly   670 TVRFVGACIDLPRPTVLILTEYCSRGSLKDVLENEAIELDWNFRMSLIHDIVKGMNYLHNSDVAA 734

Human  1992 YRDLKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTSEGTPG-------------FRAPEV 2043
            :..|:..|.|:     :...:.||:|:|:....          ||.             :.|||:
  Fly   735 HGKLRSCNCLI-----DGRFVLKISDFGLRTLT----------TPSDFVRDQNYYLKLLWIAPEL 784

Human  2044 ARGNVI-----YNQQADVYSFGLLLYDILTTGG------------RIVEGLKFPNEFDELEIQGK 2091
            .....|     ..|:.||||||::|.:|:..||            .|:..::..|.|..|
  Fly   785 LPLTTIPGCCPATQRGDVYSFGIILEEIVNRGGPYQEARQQMDVHTILHKVRQCNGFRPL----- 844

Human  2092 LPDPVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQV----------------FDILNSAE---- 2136
                ::|..|.| .::| |:::|..:|.:||||.:.:                .|:||..|
  Fly   845 ----IRERECPP-DLLE-LMEKCWADNQEERPTFSTIRSNIRTIMKGFCENLMDDLLNRMEQYAN 903

Human  2137 -LVCL----TRRILLPK 2148
             |..|    ||::.|.|
  Fly   904 NLESLVEEKTRQLSLEK 920

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380
		LRR 8	1174..1196
		leucine-rich repeat	1175..1197	CDD:275380
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1241
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970	76/314 (24%)
		WD 1	2139..2183		5/14 (36%)
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
CG3216	NP_726013.2	PBP1_NPR_like	90..496	CDD:107368
		ANF_receptor	107..479	CDD:279440
		PKc_like	616..885	CDD:304357	72/294 (24%)
		TyrKc	627..877	CDD:197581	69/275 (25%)
		HNOBA	<882..939	CDD:285003	10/39 (26%)
		CYCc	918..1109	CDD:214485	2/3 (67%)
		Guanylate_cyc	945..1131	CDD:278633
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900