DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRK2 and Ac3

DIOPT Version :9

Sequence 1:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens
Sequence 2:	NP_610116.2	Gene:	Ac3 / 35419	FlyBaseID:	FBgn0023416	Length:	1167	Species:	Drosophila melanogaster

Alignment Length:	977	Identity:	174/977 - (17%)
Similarity:	304/977 - (31%)	Gaps:	406/977 - (41%)

- Green bases have known domain annotations that are detailed below.

Human  1157 SFSAR--------MNFLAAMPFLPPSMTILKLSQNKFSCIPEAI-LNLPHLRSLDMSSNDIQYLP 1212
            |||.|        :|||..:. ||..:..|.||   ..||...| |:||               .
  Fly   156 SFSPRDLLGWAILLNFLVYVT-LPLQLIFLGLS---IGCITYFICLSLP---------------V 201

Human  1213 GPAHWKSLNLRELLFSHNQISILDLSEKAYLWSRVEKLHLSHNKLKEIPPEIGCLENLTSLDVSY 1277
            |.:||.||       ..||     |:..|.|.:....:.|.:..:.|...:...||...||:|..
  Fly   202 GYSHWDSL-------LSNQ-----LAANAVLIATAALIGLLYYFMGEAKQKRAFLEAKKSLEVKM 254

Human  1278 NLELRSFPNEMGKLSKIWDLPLDELHLNFDFKHIGCK---------------------------- 1314
            .:|.:|...|...||.   ||          ||:..|
  Fly   255 VIEEQSAEQERLLLSV---LP----------KHVAIKMREDLGSSSSEAFKKIYMSRHENVSILY 306

Human  1315 --------------AKDIIRFLQQRLKK----AVPYNRMKLMIVG-------------------- 1341
                          |:|:::.|.:...:    |..|.::::.|:|
  Fly   307 ADIVGFTAISSTYSAQDLVKMLNELFARFDRLAEKYQQLRIKILGDCYYCISGAPDERPDHAVLC 371

Human  1342 -NTGSGKTTLLQQLMKTKKSDLGMQSATVGIDV----------KDWPIQIRDKRKRDLVL-NVWD 1394
             :.|......::.:.:...|.:.|:   |||..          :.|...:..|   |:.| |..:
  Fly   372 VHMGLSMVKAIKYVQQKANSPVDMR---VGIHTGAVLAGILGQRQWQFDVYSK---DVELANKME 430

Human  1395 FAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVDA--------------MKPWLFNIKARASSS 1445
            .:|:    :...|...:...:|      .|:.||:|              :|.:......:|.:|
  Fly   431 SSGK----AGRVHISDKTLAFL------NGEFEVEAAFGEKREELLRIAGLKTYFITKVVKAFAS 485

Human  1446 PVILV--------------GTHLD-VSDEKQRKACMSKITKELLNKRGFPAIRDYHFVN--ATEE 1493
            |....              |:..| ||||....|.:.  .:|||.:.   ::.:.|.:.  .|.:
  Fly   486 PCAKKINETQAEIAHPNPNGSTTDIVSDEDDNDATLD--DEELLAQN---SVSNGHQIGIAVTAD 545

Human  1494 SDALAKLRKTIINESLNFK--IRDQLVVGQLIPDCYVELEKIILSERKNVPIEFPVIDRKRLLQL 1556
            .:...||.        |||  ::|:||.    .|.:..|.|     ..|:.:.|.....::|..:
  Fly   546 EEEQVKLE--------NFKQRLKDELVT----RDGHENLTK-----DTNIFLRFKNPQLEQLYAV 593

Human  1557 VRENQLQL---------------DENELPHA-VHFLNESGVLL--------------------HF 1585
            .||....|               ....||.: :||:|.:..|:                    .|
  Fly   594 YREPYSSLPLLAALLVQCIDVLYSYLVLPRSTLHFINIAAPLVPIAMLVVISLAESFSGMLPKFF 658

Human  1586 QDPALQLSDLYFVEPKWLCKIMAQILTVKVEGCPK-----------HPKGIISRRD--------- 1630
            .|.:.:.:|:.||      :.:|.|:.....|...           ..:.|:|..:
  Fly   659 VDVSKRFNDITFV------RELAAIIIALTIGFSNVIDMFFFVTFVRTEHIVSESEFNVTASLES 717

Human  1631 -----VEKFLSKKRKFPKNYMSQYFKLLEKFQIALPIGEEYLLVPSSLSDHRPVI--------EL 1682
                 ||..::.:...|.::       :|:.:.|:|  .|.:|.||.||:...:|        :|
  Fly   718 DINLVVEGMVTAEHLLPASF-------VEQMRDAVP--TERVLYPSYLSNFGVLILIAIAVIAQL 773

Human  1683 PHCENSEIIIRLYEMP-YFPMGFWSRLINRLLEISPYMLSGRERALRPNRMYWRQGIYLNWSPEA 1746
            .|.....:::.:..:. ||                              .::..|.:|
  Fly   774 THLTKILLLLSIAALHCYF------------------------------NIFIMQDLY------- 801

Human  1747 YCLVGSEVLDNHPESFLKITVPSCRKGCIL--------LGQVVDHIDSLMEEWFPGLLEIDICGE 1803
                   .|::..|....|:......|.:|        |.:.:||.|.::.:|     :.::..:
  Fly   802 -------ALEDDFEHQPIISTRYAASGLLLVAALALSTLARHMDHEDRVIFKW-----KTEVAEQ 854

Human  1804 GETLLKKWALYSFNDGEEHQKILL--------------------DDLMKK--AEEGDLLVNPDQP 1846
            .||.         ||..:..:.|:                    |||..:  ||.|.|..:
  Fly   855 KETA---------NDMRQRNEALVYNVLPVHVAEHFMKNTKRSHDDLYSQSYAEVGVLFAS---- 906

Human  1847 RLTIPISQIAPDLILADLPRNIMLNNDELE-----------FE---QAPEF--LLGDGSFGSVYR 1895
                     .|:  .:|......:||..||           |:   :.|:|  ::...:.||.|.
  Fly   907 ---------MPN--FSDFYSEETVNNQGLECLRFLNEVISDFDALLELPQFQDIIKIKTIGSTYM 960

Human  1896 AA 1897
            ||
  Fly   961 AA 962

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223	37/137 (27%)
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380	9/24 (38%)
		LRR 8	1174..1196		7/22 (32%)
		leucine-rich repeat	1175..1197	CDD:275380	8/22 (36%)
		LRR 9	1197..1218		2/20 (10%)
		leucine-rich repeat	1198..1221	CDD:275380	4/22 (18%)
		LRR 10	1221..1241		3/19 (16%)
		leucine-rich repeat	1222..1246	CDD:275380	5/23 (22%)
		LRR 11	1246..1267		2/20 (10%)
		leucine-rich repeat	1247..1269	CDD:275380	3/21 (14%)
		LRR 12	1269..1291		6/21 (29%)
		RocCOR	1334..1507	CDD:206741	38/235 (16%)
		COR	1527..1740	CDD:318343	42/282 (15%)
		STKc_LRRK2	1884..2135	CDD:270970	5/14 (36%)
		WD 1	2139..2183
		WD 2	2188..2228
		WD 3	2233..2276
		WD 4	2281..2327
		WD 5	2333..2377
		WD 6	2402..2438
		WD 7	2443..2497
Ac3	NP_610116.2	AC_N	<127..285	CDD:292831	45/172 (26%)
		CYCc	256..453	CDD:214485	32/225 (14%)
		Guanylate_cyc	294..476	CDD:278633	26/197 (13%)
		CYCc	860..1071	CDD:214485	23/118 (19%)
		Guanylate_cyc	892..1092	CDD:278633	19/86 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900