DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment LRRK2 and ACXC

DIOPT Version :9

Sequence 1:	NP_940980.4	Gene:	LRRK2 / 120892	HGNCID:	18618	Length:	2527	Species:	Homo sapiens
Sequence 2:	NP_609593.1	Gene:	ACXC / 34689	FlyBaseID:	FBgn0040508	Length:	1130	Species:	Drosophila melanogaster

Alignment Length:	814	Identity:	149/814 - (18%)
Similarity:	264/814 - (32%)	Gaps:	298/814 - (36%)

- Green bases have known domain annotations that are detailed below.

Human  1858 DLILADLPRNIMLNNDELEFEQAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLR-LLRQEL 1921
            |:|..|:..|:..|...:.|.     ::.|    ::.||::....   :...:.|.|| .|.||.
  Fly   211 DVISTDILHNLGFNMMGIFFR-----IMND----TMVRASFLDRH---QFIMEETWLRHALLQES 263

Human  1922 VVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRTLQHRIALHVADGLRYLH 1986
            ::|..:..|.:...:...|:.::    ..|:.|.||....     .||.:..:|:.:...:..|:
  Fly   264 ILLDSILPPQIAKPVQEKIKSKI----TQSENSPDRFQMG-----PRTTESFMAIQIHPDVSILY 319

Human  1987 SAMIIYRDLKP----HNV--LLFTLYPNAAIIA------KIADYGIAQYCCRMGIKTSEGTPGFR 2039
            :.::.|..|..    .|:  :|..||....|.|      :|...|...||. .|:.|.:  |...
  Fly   320 ADVVNYTHLTTTLTVGNLVKVLHDLYGRFDIAASNFKVQRIKFLGDCYYCV-AGLTTPD--PDHA 381

Human  2040 APEVARG-NVIYNQQADVYSFGLLLYDI-LTTG---GRIVEGLKFPNEFDELEIQGKLPDPVKEY 2099
            ...|:.| ::|.|.|......||   || :..|   |.::.|:     ..|.::|
  Fly   382 KCCVSLGISMISNIQEVRAERGL---DIDMRIGVHSGSLLAGI-----IGEAKLQ---------- 428

Human  2100 GCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAELVCLTRRILLPKNVIVECMVATHHNSRN 2164
                                         |||..:                  :..:|.|..|..
  Fly   429 -----------------------------FDIWGT------------------DVEIANHLESTG 446

Human  2165 ASIWLGCGHTDRGQLSFLDLNTEGYT----SEEVADSRILCLALVHL---PVEKESWIVS--GTQ 2220
            ..   |..|.....||.  ||...||    :::.....:|.....:|   .|.:||:|.|  |.:
  Fly   447 EP---GYVHVSGRTLSM--LNPADYTILSGTQKAQSDPVLQYIHTYLLTGQVARESFITSIGGVR 506

Human  2221 SGTLLVINTED--GKKRHTLEKMTD-----------------SVTC----------------LYC 2250
            |.::|.:.:.|  ...|.:...|||                 |..|                ::|
  Fly   507 SSSVLEVKSIDRIRSSRPSQSSMTDEFREEFRNMPVGGINLNSPCCRRTRLDTHKKTQREIGIFC 571

Human  2251 NSFSKQSKQKNFL-----------LVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVS------- 2297
            .:|...|.:.|:|           |:....|...|:            ::|:. .|.|
  Fly   572 AAFKDSSLEWNYLHQPDFIFKSSMLLAWGIGCCLIY------------IQIVT-NNFSCTACIVV 623

Human  2298 --------TPLMCLSESTNSTERNVMWGGCGTKIFSFSNDFT---------IQKLIETRTSQ--- 2342
                    |.|:||     :..:||.|...|...|.....::         ||..:..|.:.
  Fly   624 DLVTFFFLTSLLCL-----AWYKNVCWWKSGRYEFRIYGKYSCMAFHIFEKIQHSVSLRITVYLG 683

Human  2343 -LFSYAAFSDSNIITVVVDTALYIAKQNSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKH 2406
             ||||.|     :|:::                           :::|...:.|:...|:|...:
  Fly   684 ILFSYYA-----VISLI---------------------------MLNCDRDMYELSYIESKIYHY 716

Human  2407 KMSYSGRVKTLCLQKNTALWIGTGGGHILL-LDLSTRRL---IRVIYNFCNSVRVM--------- 2458
            :|.     :..|...    |:.|....::| :..:..|:   ::::.:.|.::..:
  Fly   717 EMD-----RDTCFHP----WVFTNMISLILGISYTFARIPFGLKIVISCCETLAYLLIVFFQFAF 772

Human  2459 -----------MTAQLGSLKNVMLVL----------GYNRK-----NTEGTQKQKEI----QSCL 2493
                       |.|:|.....|.::|          .:|.|     |.:...|||..    ||.:
  Fly   773 IFQHSATTTPFMKAELAHCLRVCMMLLTMYAKERQSEFNTKMNYKLNVDLQNKQKAADLTNQSII 837

Human  2494 TVWDINLPHEVQNLEKHIEVRKEL-AEKMRRTSV 2526
            .:.:..||..|.:|..:...:.|| .|..|..||
  Fly   838 ILLNNILPSHVVDLYLNSLAKHELYYENYRMVSV 871

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
LRRK2	NP_940980.4	Required for RAB29-mediated activation. /evidence=ECO:0000269\|PubMed:29212815	1..969
		LRR 1	983..1004
		leucine-rich repeat	985..1012	CDD:275380
		LRR	1012..>1286	CDD:227223
		LRR 2	1012..1033
		leucine-rich repeat	1013..1036	CDD:275380
		LRR 3	1036..1057
		leucine-rich repeat	1037..1084	CDD:275380
		LRR 4	1059..1080
		LRR 5	1084..1105
		leucine-rich repeat	1085..1108	CDD:275380
		LRR 6	1108..1129
		leucine-rich repeat	1109..1130	CDD:275380
		LRR 7	1130..1150
		leucine-rich repeat	1131..1174	CDD:275380
		LRR 8	1174..1196
		leucine-rich repeat	1175..1197	CDD:275380
		LRR 9	1197..1218
		leucine-rich repeat	1198..1221	CDD:275380
		LRR 10	1221..1241
		leucine-rich repeat	1222..1246	CDD:275380
		LRR 11	1246..1267
		leucine-rich repeat	1247..1269	CDD:275380
		LRR 12	1269..1291
		RocCOR	1334..1507	CDD:206741
		COR	1527..1740	CDD:318343
		STKc_LRRK2	1884..2135	CDD:270970	52/268 (19%)
		WD 1	2139..2183		7/43 (16%)
		WD 2	2188..2228		12/48 (25%)
		WD 3	2233..2276		14/86 (16%)
		WD 4	2281..2327		12/60 (20%)
		WD 5	2333..2377		8/47 (17%)
		WD 6	2402..2438		6/36 (17%)
		WD 7	2443..2497		15/95 (16%)
ACXC	NP_609593.1	AC_N	<33..285	CDD:292831	18/85 (21%)
		CYCc	293..468	CDD:214485	48/252 (19%)
		Nucleotidyl_cyc_III	307..466	CDD:299850	43/231 (19%)
		CYCc	833..1060	CDD:214485	12/39 (31%)
		Nucleotidyl_cyc_III	861..1085	CDD:299850	5/11 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG2114
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900