Sequence 1: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
---|---|---|---|---|---|---|---|---|---|
Sequence 2: | NP_511156.2 | Gene: | rut / 32406 | FlyBaseID: | FBgn0003301 | Length: | 2248 | Species: | Drosophila melanogaster |
Alignment Length: | 972 | Identity: | 176/972 - (18%) |
---|---|---|---|
Similarity: | 312/972 - (32%) | Gaps: | 307/972 - (31%) |
- Green bases have known domain annotations that are detailed below.
Human 1137 SKNHISSLSENFLEAC--PKVESFSARMNFLAA-----MPFLPPSMTILKLS-----------QN 1183
Human 1184 KFSCIPEAI-LNLP-HLRSLDMSSNDIQYLPGPAHWKSLNLRELLFSHNQISIL-------DLSE 1239
Human 1240 KAYLWSRVEKLHLSHNK-----LKEIPPEIGCLENLTS-------LDVSYNLELRSFPNEMGKLS 1292
Human 1293 KIW-DLP-LDELHLNFDFKHIGCKA----KDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLL 1351
Human 1352 QQLMKTKKSDLGMQSATVGIDVKDWPIQIRDK---RKRDLVLNVWDFAGREEFYSTHPHFMTQRA 1413
Human 1414 LYLAVYDLSKGQAEVDAMKP----W--LFNIKARASSSPVILVGTHLDVSDEKQRKACMSKITKE 1472
Human 1473 LLNKRGFPAIRDYHF-------VNATEESDALAKLRKTIINESLNFKIRDQLVVGQLI--PDCYV 1528
Human 1529 ELEKIILSERKNVPIEFPVIDRKRLLQLVRENQLQLD-----ENELPHAVHFLNESGVLL---HF 1585
Human 1586 QDPALQL--------SDLYFVEPKWL-CKIMAQILTVKVEGCP-----------KHPKGIISRRD 1630
Human 1631 VEKFLSKKRKF-------------------PKNYMSQYFKLLEKFQ----------IALPIGEEY 1666
Human 1667 LLVPSSLSDHRPV-----IELPHCENSEIIIRLYEMPYFP------------MGFWSRLINRLLE 1714
Human 1715 ISPYMLSGRERALR------------PNRMYWRQGIYLNWSPEAYCLVGSEVLDNHPESFLKITV 1767
Human 1768 PSCRKGCILL-GQVVDHIDSLMEEWFPGLLEIDICGEGETLLKKWALYSFNDGEEHQ----KILL 1827
Human 1828 DDLMKKAEEGDLL-----VNPDQPRL---------TIPISQIAPDLILADLPRNIMLNNDELEFE 1878
Human 1879 QAPEFLLGDGSFGSVYRAAYEGEEVAVKIFNKHTSLRLLRQELVVLCHLHHPSLISLLAAGI 1940 |
Gene | Sequence | Domain | Region | External ID | Identity |
---|---|---|---|---|---|
LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | ||
LRR 1 | 983..1004 | ||||
leucine-rich repeat | 985..1012 | CDD:275380 | |||
LRR | 1012..>1286 | CDD:227223 | 40/187 (21%) | ||
LRR 2 | 1012..1033 | ||||
leucine-rich repeat | 1013..1036 | CDD:275380 | |||
LRR 3 | 1036..1057 | ||||
leucine-rich repeat | 1037..1084 | CDD:275380 | |||
LRR 4 | 1059..1080 | ||||
LRR 5 | 1084..1105 | ||||
leucine-rich repeat | 1085..1108 | CDD:275380 | |||
LRR 6 | 1108..1129 | ||||
leucine-rich repeat | 1109..1130 | CDD:275380 | |||
LRR 7 | 1130..1150 | 3/12 (25%) | |||
leucine-rich repeat | 1131..1174 | CDD:275380 | 11/43 (26%) | ||
LRR 8 | 1174..1196 | 6/33 (18%) | |||
leucine-rich repeat | 1175..1197 | CDD:275380 | 6/34 (18%) | ||
LRR 9 | 1197..1218 | 4/20 (20%) | |||
leucine-rich repeat | 1198..1221 | CDD:275380 | 3/22 (14%) | ||
LRR 10 | 1221..1241 | 5/26 (19%) | |||
leucine-rich repeat | 1222..1246 | CDD:275380 | 7/30 (23%) | ||
LRR 11 | 1246..1267 | 6/25 (24%) | |||
leucine-rich repeat | 1247..1269 | CDD:275380 | 7/26 (27%) | ||
LRR 12 | 1269..1291 | 4/28 (14%) | |||
RocCOR | 1334..1507 | CDD:206741 | 30/188 (16%) | ||
COR | 1527..1740 | CDD:318343 | 45/298 (15%) | ||
STKc_LRRK2 | 1884..2135 | CDD:270970 | 13/57 (23%) | ||
WD 1 | 2139..2183 | ||||
WD 2 | 2188..2228 | ||||
WD 3 | 2233..2276 | ||||
WD 4 | 2281..2327 | ||||
WD 5 | 2333..2377 | ||||
WD 6 | 2402..2438 | ||||
WD 7 | 2443..2497 | ||||
rut | NP_511156.2 | AC_N | <17..255 | CDD:292831 | |
CYCc | 230..425 | CDD:214485 | |||
Guanylate_cyc | 266..438 | CDD:278633 | |||
DUF1053 | 624..696 | CDD:283888 | |||
SLC5-6-like_sbd | <742..>893 | CDD:294310 | 25/117 (21%) | ||
CYCc | 924..1134 | CDD:214485 | 46/254 (18%) | ||
Guanylate_cyc | 954..1151 | CDD:278633 | 40/239 (17%) | ||
Blue background indicates that the domain is not in the aligned region. |
Tool | Simple Score | Weighted Score | Original Tool Information | |||
---|---|---|---|---|---|---|
BLAST Result | Score | Score Type | Cluster ID | |||
Compara | 0 | 0.000 | Not matched by this tool. | |||
Domainoid | 0 | 0.000 | Not matched by this tool. | |||
eggNOG | 1 | 0.900 | - | - | E1_COG2114 | |
Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
Homologene | 0 | 0.000 | Not matched by this tool. | |||
Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
Isobase | 0 | 0.000 | Not matched by this tool. | |||
OMA | 0 | 0.000 | Not matched by this tool. | |||
OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
Panther | 0 | 0.000 | Not matched by this tool. | |||
Phylome | 0 | 0.000 | Not matched by this tool. | |||
RoundUp | 0 | 0.000 | Not matched by this tool. | |||
SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
TreeFam | 0 | 0.000 | Not matched by this tool. | |||
User_Submission | 0 | 0.000 | Not matched by this tool. | |||
1 | 0.900 |