| Sequence 1: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_732554.1 | Gene: | Takl1 / 318725 | FlyBaseID: | FBgn0046689 | Length: | 393 | Species: | Drosophila melanogaster |
| Alignment Length: | 281 | Identity: | 82/281 - (29%) |
|---|---|---|---|
| Similarity: | 140/281 - (49%) | Gaps: | 48/281 - (17%) |
- Green bases have known domain annotations that are detailed below.
|
Human 1874 ELEFEQA--PEFLLGDGSFGSVYRAAYEGEEVAVKIFN--KHTSLRLLRQELVVLCHLHHPSLIS 1934
Human 1935 LL--AAGIRPRMLVMELASKGSLDRLLQ-QDKASLTRTLQHRIALHVADGLRYLHS--AMIIYRD 1994
Human 1995 LKPHNVLLFTLYPNAAIIAKIADYGIAQYCCRMGIKTS-EGTPGFRAPEVARGNVIYNQQADVYS 2058
Human 2059 FGLLLYDILTTG----------------GRIVEGLKFPNEFDELEIQGKLPDPVKEYGCAPWPMV 2107
Human 2108 EKLIKQCLKENPQERPTSAQV 2128 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | ||
| LRR 1 | 983..1004 | ||||
| leucine-rich repeat | 985..1012 | CDD:275380 | |||
| LRR | 1012..>1286 | CDD:227223 | |||
| LRR 2 | 1012..1033 | ||||
| leucine-rich repeat | 1013..1036 | CDD:275380 | |||
| LRR 3 | 1036..1057 | ||||
| leucine-rich repeat | 1037..1084 | CDD:275380 | |||
| LRR 4 | 1059..1080 | ||||
| LRR 5 | 1084..1105 | ||||
| leucine-rich repeat | 1085..1108 | CDD:275380 | |||
| LRR 6 | 1108..1129 | ||||
| leucine-rich repeat | 1109..1130 | CDD:275380 | |||
| LRR 7 | 1130..1150 | ||||
| leucine-rich repeat | 1131..1174 | CDD:275380 | |||
| LRR 8 | 1174..1196 | ||||
| leucine-rich repeat | 1175..1197 | CDD:275380 | |||
| LRR 9 | 1197..1218 | ||||
| leucine-rich repeat | 1198..1221 | CDD:275380 | |||
| LRR 10 | 1221..1241 | ||||
| leucine-rich repeat | 1222..1246 | CDD:275380 | |||
| LRR 11 | 1246..1267 | ||||
| leucine-rich repeat | 1247..1269 | CDD:275380 | |||
| LRR 12 | 1269..1291 | ||||
| RocCOR | 1334..1507 | CDD:206741 | |||
| COR | 1527..1740 | CDD:318343 | |||
| STKc_LRRK2 | 1884..2135 | CDD:270970 | 80/269 (30%) | ||
| WD 1 | 2139..2183 | ||||
| WD 2 | 2188..2228 | ||||
| WD 3 | 2233..2276 | ||||
| WD 4 | 2281..2327 | ||||
| WD 5 | 2333..2377 | ||||
| WD 6 | 2402..2438 | ||||
| WD 7 | 2443..2497 | ||||
| Takl1 | NP_732554.1 | S_TKc | 15..262 | CDD:214567 | 80/268 (30%) |
| STKc_TAK1 | 17..274 | CDD:270960 | 80/268 (30%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E2759_KOG0192 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||