| Sequence 1: | NP_940980.4 | Gene: | LRRK2 / 120892 | HGNCID: | 18618 | Length: | 2527 | Species: | Homo sapiens |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_728725.2 | Gene: | CG32305 / 317967 | FlyBaseID: | FBgn0052305 | Length: | 1164 | Species: | Drosophila melanogaster |
| Alignment Length: | 1344 | Identity: | 252/1344 - (18%) |
|---|---|---|---|
| Similarity: | 437/1344 - (32%) | Gaps: | 457/1344 - (34%) |
- Green bases have known domain annotations that are detailed below.
|
Human 15 TLKKLIVR-LNNVQEGKQIETLVQILEDLLVFTYSERASKLFQGKNI-----HVPLLIVLDSYMR 73
Human 74 VASVQQVGWSLLCKLIEVCPGTMQSLMGPQDVGNDWEVLGVHQLILKMLTVHNASVNLSVIGLKT 138
Human 139 LDLLLTSGKITLLILDEESDIFMLIFD--AMHSFPANDEVQKLGC-KALHVLFERVSEEQLTEFV 200
Human 201 ENKDYMILLSALTNFKDEEEIVLHVLHCLHSLAIPCNNVEVLMS--GNVRCYNIVVEAMKAFPMS 263
Human 264 ERIQEVSCCLLHRLTLGNFFNILVLNEVHEFVVKAVQQYPENAALQ-ISALSCLALLTETIFLNQ 327
Human 328 DLEEKNENQENDDEGEEDKLFWLE------------ACYKALTWHRKNKHVQEAACWALNNLLM- 379
Human 380 ------YQNSLHEK-IGDE-------DGHFPAHREVMLSMLMHSSSKEVFQASANALSTL-LEQN 429
Human 430 VNFRKILLSKGIHLNVLELMQKHIHSPEVAESGCKMLNHLFEGSNTSLDIMAAVVPKILTVMKRH 494
Human 495 ETS-LPVQLEALRAIL-----HFIVPGMPEESREDTEFHHKLNMVKKQCFKNDIHKLVLAALNRF 553
Human 554 IGNPGIQKCGLKVISSIVHFPDALEMLSLEGAMDSVLHTLQMYPDDQEIQCLGLSLIGYL----- 613
Human 614 -----ITKKNVFIGTGHLLAKILVSSLYRFKDVAE--IQTKGFQTILAILKLSASFSKLLVHHSF 671
Human 672 -DLVIFHQ-----------MSSNIMEQKDQQ-----------FLNLCC----------------- 696
Human 697 ---KCFAK---VAMDDYLKNVMLERACDQNNSIMVECLLLLGADANQAKEGSSLICQVCEKESSP 755
Human 756 KLVEL-LLNSGSREQ-----DVRKALTISIG-----KGDSQIISLLLRRLALDVANNSICL-GGF 808
Human 809 CIGKVEPSWLG------------PLF------PDKTSNLRK--------------QT-------- 833
Human 834 ----NIASTLARMVIRYQ----------------MKSAVEEGTASGSDGNFSEDVLSKFDE---- 874
Human 875 --------------WTFI----------PDSSMDSVFAQSDDLDSEGSEGSFLVKKKSNSISVGE 915
Human 916 FYRDAVLQRCSPNLQRHSNSLGPIFDHE-DLLK-----RKRKILSSDDSLRSSKLQSHMRHSDSI 974
Human 975 SSLA--SEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLELHQNALTSFPQQLCETLKSL 1037
Human 1038 THLDLHSN--------KFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCPTLKQFNLSYN- 1093
Human 1094 ---------QLSFVP------ENLTDVVE---KLEQLILEGNKI 1119 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| LRRK2 | NP_940980.4 | Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815 | 1..969 | 221/1163 (19%) | |
| LRR 1 | 983..1004 | 3/20 (15%) | |||
| leucine-rich repeat | 985..1012 | CDD:275380 | 4/26 (15%) | ||
| LRR | 1012..>1286 | CDD:227223 | 24/135 (18%) | ||
| LRR 2 | 1012..1033 | 1/20 (5%) | |||
| leucine-rich repeat | 1013..1036 | CDD:275380 | 2/22 (9%) | ||
| LRR 3 | 1036..1057 | 5/28 (18%) | |||
| leucine-rich repeat | 1037..1084 | CDD:275380 | 9/54 (17%) | ||
| LRR 4 | 1059..1080 | 4/20 (20%) | |||
| LRR 5 | 1084..1105 | 6/36 (17%) | |||
| leucine-rich repeat | 1085..1108 | CDD:275380 | 8/41 (20%) | ||
| LRR 6 | 1108..1129 | 4/12 (33%) | |||
| leucine-rich repeat | 1109..1130 | CDD:275380 | 4/11 (36%) | ||
| LRR 7 | 1130..1150 | ||||
| leucine-rich repeat | 1131..1174 | CDD:275380 | |||
| LRR 8 | 1174..1196 | ||||
| leucine-rich repeat | 1175..1197 | CDD:275380 | |||
| LRR 9 | 1197..1218 | ||||
| leucine-rich repeat | 1198..1221 | CDD:275380 | |||
| LRR 10 | 1221..1241 | ||||
| leucine-rich repeat | 1222..1246 | CDD:275380 | |||
| LRR 11 | 1246..1267 | ||||
| leucine-rich repeat | 1247..1269 | CDD:275380 | |||
| LRR 12 | 1269..1291 | ||||
| RocCOR | 1334..1507 | CDD:206741 | |||
| COR | 1527..1740 | CDD:318343 | |||
| STKc_LRRK2 | 1884..2135 | CDD:270970 | |||
| WD 1 | 2139..2183 | ||||
| WD 2 | 2188..2228 | ||||
| WD 3 | 2233..2276 | ||||
| WD 4 | 2281..2327 | ||||
| WD 5 | 2333..2377 | ||||
| WD 6 | 2402..2438 | ||||
| WD 7 | 2443..2497 | ||||
| CG32305 | NP_728725.2 | CYCc | 251..449 | CDD:214485 | 49/240 (20%) |
| Nucleotidyl_cyc_III | 292..445 | CDD:299850 | 36/191 (19%) | ||
| CYCc | 814..1056 | CDD:214485 | 43/267 (16%) | ||
| Nucleotidyl_cyc_III | 845..1081 | CDD:299850 | 44/280 (16%) | ||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_COG2114 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 0 | 0.000 | Not matched by this tool. | |||
| RoundUp | 0 | 0.000 | Not matched by this tool. | |||
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 1 | 0.900 | |||||