DRSC/TRiP Functional Genomics Resources

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Protein Alignment LRRK2 and lrk-1

DIOPT Version :10

Sequence 1:NP_940980.4 Gene:LRRK2 / 120892 HGNCID:18618 Length:2527 Species:Homo sapiens
Sequence 2:NP_492839.4 Gene:lrk-1 / 172995 WormBaseID:WBGene00003068 Length:2393 Species:Caenorhabditis elegans


Alignment Length:2615 Identity:557/2615 - (21%)
Similarity:959/2615 - (36%) Gaps:852/2615 - (32%)


- Green bases have known domain annotations that are detailed below.


Human   317 ALLTETIFLNQDLEEKNENQENDDEGEEDKLFWLEACYKALTWHRKNKHVQEAACWALNN----- 376
            |:|.|.:.|..||.:.|.              |:        |:|.::|.:.....|.:|     
 Worm    30 AVLFENVELLADLFKVNP--------------WV--------WNRVDRHGRTPLMLAAHNGKLDS 72

Human   377 ----LLMYQNSLH-------------------------EKIG------DEDGH-------FPAHR 399
                |::..|||:                         .::|      |.:||       ...|.
 Worm    73 LRTILMLSPNSLNLVNDRGKTALHMAAESGETSIVLELVELGSDPMKSDNEGHCALELAQMAGHN 137

Human   400 EVMLSML--MHSSSKEVFQASANALSTLLEQNVNFRKILLSKGIHLNVLELMQKHIHSPEVAESG 462
            ||...::  :...|:::.:|....:|..:..:.:.            |.|:.::.:...:..|. 
 Worm   138 EVAAKLIDAIQKESEDLNEAHTMIISACISGSADV------------VYEISRRFMEKKQSREI- 189

Human   463 CKMLNHLFEGSNTSLDIMAAVVPKILTVMKRHETSLPV-----QLEALRAILHFIVPGMPEESRE 522
                  ||.|.|                 :..||:|.:     .:|.:|.:|.|....:.....:
 Worm   190 ------LFNGRN-----------------EEDETALLIACTNGHIEIVRHLLQFEEHLLQSHVSK 231

Human   523 DTEFHHKLNMVKKQCFKNDIHKLVLAALNRFIGNPG------IQKCG-LKVISSIVHFPDALEML 580
            ||..|..::....:..:..:.|  ...|.:...|.|      ..:|| .:.:|:|::||...|.:
 Worm   232 DTVIHAAVSSQNVEVLQLCLEK--FPQLVKSTNNEGSTCLHWAARCGSSECVSTILNFPFPSEFI 294

Human   581 SLEGAMDSV-LHTLQMYPDDQEIQCLGLSLIGYLITKKNVFIGTGHLLAKILVSSLYRFK--DVA 642
             :|  :|:| ....|:..|..|:.       |...|...:.:..|||   .:|.::..||  .:.
 Worm   295 -IE--IDTVGAPAYQLALDVNEVD-------GECRTAMYLAVAEGHL---EVVKAMTDFKCTSID 346

Human   643 EIQTKGFQTILAILKLSASFSKLLVHHSFDLVIFHQMSSNIMEQKDQQFLNLCCKCFAKVAMDDY 707
            ..|...||..:...:....|.         |..|:|              ||            .
 Worm   347 GRQRCPFQLDVYCTRGRTPFM---------LAAFNQ--------------NL------------P 376

Human   708 LKNVMLERACDQNNSIMVECLLLLGADANQAKE-----GSSLICQVCEKESSPKLVELLLNSGSR 767
            |..::|:...|.|       |.|...|...:.|     ||..:.:....:.. .:|..||:.|:.
 Worm   377 LMTLLLDAGADVN-------LPLAVLDTEYSVEEGRCIGSGALVEAVRSDGL-HIVHFLLDRGAL 433

Human   768 EQDVRKALTISI-GKGDSQIISLLLRRLALD----VANNSICLGGFCIGK-VEPSWLGPLFPDKT 826
            :.| .|||.::. ||.:..|...|:|.:..|    :...:|.:|...:|: :.||   .|.|.|.
 Worm   434 DTD-NKALRLAAQGKNEKLIRVFLVRLVFADPEYKINKKNIDVGQIQVGQSLLPS---SLCPSKA 494

Human   827 SNLRKQTNIASTLARMVIRYQMKSAVEEGTASGSDGNFSEDVLSKFDEWTFIPDSSMDSVFAQSD 891
            :.|                                            .|                
 Worm   495 AQL--------------------------------------------NW---------------- 499

Human   892 DLDSEGSEGSFLVKKKSNSISVGEFYRD---AVLQRCSPNLQRHSNSLGPIFDHEDLLKRKRKIL 953
                             ||.::.:...|   |.....:|.|:....||..|          .::.
 Worm   500 -----------------NSANLEQLQSDWFVAAALHVNPRLRTTRLSLAAI----------TRVD 537

Human   954 SSDDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEKLEL 1018
            .||:.|            ::..|:..:...:.||:|:.|.:|.|:..:    ..:....||.|.|
 Worm   538 LSDNRL------------NTFPSILFQMPSLRSLNLADNSIRKIEIPT----YYISSTSLEILNL 586

Human  1019 HQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSCIANLDVSRNDIGPSVVLDPTVKCP 1083
            ..|.|.....|...:|..|..||:..|:.:..|.|:.                         .||
 Worm   587 RNNQLECIAIQFLSSLPQLQQLDVSKNELSQLPEYIW-------------------------LCP 626

Human  1084 TLKQFNLSYNQLSFVPE-------------------NLTDVVEKLEQLILEG--NKISGICSPLR 1127
            .||:.|.|||:||.:|.                   |.....::...::::.  |..|   :|||
 Worm   627 ALKELNASYNRLSTLPMVARASRGERPRLNNSNNNFNTQSPTQESNPIVVDDPPNVTS---NPLR 688

Human  1128 LKEL--KILNLSKNHISSLSENF-LEACPKVESFSARMNFLAAMPF----LPPSMTILKLSQNKF 1185
            .:.:  ..:||||....||..:| :.:...:.:.:...|.....||    ..|.:.||.:|.|..
 Worm   689 RQNVWQASINLSKVDDDSLFPDFPVTSSNTLTTINLSFNKFHTFPFCLACTCPRLLILNMSNNSM 753

Human  1186 SCIPEAILNLPHLRSLDMSSNDIQ------------------------YLP----GPAH------ 1216
            :.:|.......|||:||:|.|.||                        .||    .||.      
 Worm   754 TSLPPMACVPAHLRTLDLSYNKIQESFIEASPLHVVCHAVPPTTSNGSMLPKRRNSPARQHRSRS 818

Human  1217 ------WKSLN---------------------------LRELLFSHNQ---ISILDLSEKAYLWS 1245
                  .:||:                           |:.|..:.|:   ||:.:.:.|..| .
 Worm   819 KSAVRSQRSLSVSRHHALIDPQKEEESCVHKRHDSLEWLKTLQLAGNRLRSISVTNAASKVLL-P 882

Human  1246 RVEKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFDFKH 1310
            .:..:.:|.|||.:.||::..|..|:.|::|.|..::..|.:.|.||::|.|.|....|....:.
 Worm   883 ALNVMDISDNKLLQAPPDVARLTLLSMLNLSGNTAIKELPPDYGMLSRLWSLSLKGCSLKEPLES 947

Human  1311 I----GCKAKDIIRFLQQRLKKAVPYNRMKLMIVGNTGSGKTTLLQQLMK---TKKSDLGMQSAT 1368
            :    .||..:|:.:|:..|:::..|:.::|||:|:.|.||:.:...|.|   .|:..:  .|.|
 Worm   948 MVNVENCKTVEIVAYLKTILEESKTYHHLRLMILGSDGVGKSVIWDALCKEAVQKRQPI--HSET 1010

Human  1369 VGIDVKDWPIQIR----DKRKRDLVLNVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAEVD 1429
            ..|...:|..:.:    ||....:..:|.||.|:.|::|||.:|:::|:|.|.::.::.|...:.
 Worm  1011 GVIRQAEWKFEAKRSKGDKNLGPVGFSVIDFGGQREYHSTHQYFLSKRSLNLVLWKITDGDEALA 1075

Human  1430 AMKPWLFNIKARASSSPVILVGTHL---------------DVSDEKQRKACMSKITKELL---NK 1476
            .:..||.||.|||.:|.||||||:|               |:.::|.|       |:.::   :|
 Worm  1076 QLDTWLVNIHARAPNSTVILVGTNLDQVASNSSKFGPGYIDIMEQKVR-------TRYMVADADK 1133

Human  1477 RGFPAIRDYHFVNATEESDALAKLRKTIINESLNFKIRDQLVVGQLIPDCYVELEKIILSERKNV 1541
            .|.|.|.|...:|:|..:|..| |..||...:...::..:..:.|.||..|:.|.|:    .|.:
 Worm  1134 SGLPRIVDVILINSTSRNDVKA-LLNTIYRTAWEVRMGKERAMEQQIPSSYIALMKV----TKEL 1193

Human  1542 PIEF-----PVI-------DRKRLLQLVRENQLQLDENELPHAVHFLNESGVLLHFQDPALQLSD 1594
            .:||     |.:       :|.:...:.:..:...|:.|...|..||::.|.|:.|:|..|:  |
 Worm  1194 GVEFRKEGQPAVMTVEAYRERVKKRMISKFGRPFRDDIEFYAACTFLHDCGELVRFEDATLR--D 1256

Human  1595 LYFVEPKWLCKIMAQILTVKVEGCPKHPKGIISRRDVEKFLSKKRKFPKNYM----SQYFKLLEK 1655
            |.||:|.||.:.:..::.::   .|..|.|::|   .:......|.|....:    :|...||.|
 Worm  1257 LIFVDPLWLAEFLTSVVILR---SPNLPAGLLS---TDAINPHTRSFKSGALLMLKTQLLDLLHK 1315

Human  1656 FQIALPIGEEYLLVPSSLSDHRPV-------------------IELPH----------------- 1684
            |::||......||:||.|.|...:                   :..|.                 
 Worm  1316 FELALATQPRQLLIPSLLPDEYRLRSDFLASAVKIRMKMSQWNVRCPSPAGSPTKSPLRRTSPTD 1380

Human  1685 --------------CENSEIIIRLYEMPYFPMGFWSRLINRL---------LEISPYMLSGRERA 1726
                          .::.:::.|:|.:.|.|.||||||:.|:         :| |.:|.:..:||
 Worm  1381 QNGVGSEDVMLQFTYDDDQLLRRIYALAYIPSGFWSRLVTRIVGDKNVCAAIE-SIFMTTSADRA 1444

Human  1727 ---------LRPNRMYWRQGIYLN---------------------------------------WS 1743
                     .:...:.|:.||.|:                                       |:
 Worm  1445 KIADIATKHAKAEWVVWQTGIELHVKGHSLFTLKQFLPLAEVRDIDYSAIDMRAKDEQKRWRTWN 1509

Human  1744 -----PEAYCLVGSEVLDNHPESFLKITVPSCRKG-CILLGQVVDHIDSLMEEWFPGL-LEIDIC 1801
                 |....:|.|..:....:...|:::.:..:| ..||..:.|.:|:|:|:|:|.| ......
 Worm  1510 QPSHRPIVEMVVNSLSISAASQHGRKLSMKTDVEGRSRLLAMISDLLDTLLEDWYPALGTRFVHS 1574

Human  1802 GEGETLLKKWAL------------------------YSFNDGE------EHQK------------ 1824
            .||:.|:.::.|                        .|.:|||      .|.|            
 Worm  1575 SEGDLLVSRYVLCPQCVRDAERNGSRSRTSSSASHRRSQDDGELPITSSSHMKGSRTTGDISKCR 1639

Human  1825 ------ILLDDLMKKAEEGDLLVNPDQPRLTIPISQIAPDLILADLPRNIMLNNDELEFEQAPEF 1883
                  .::::.|....|.:.:..|....|  .:.::|||.:.||:...:.::.|:|:..:    
 Worm  1640 GGVVHCFVIEECMLAGREYNWVECPSHGGL--HMRELAPDTVFADIENALTIHPDQLKRSR---- 1698

Human  1884 LLGDGSFGSVYRAAY---EGE--EVAVKIFN-----------------------KHTSLRLL--- 1917
            :||.|:||.|:||..   .||  |||.|:..                       |..|:...   
 Worm  1699 MLGRGAFGFVFRATVRQPNGELCEVAQKMLEPVDPGPGGRPSALAAYKAAADKWKRDSMEFACRA 1763

Human  1918 ----RQELVVLCHLHHPSLISLLAAGIRPRMLVMELASKGSLDRLLQQDKASLTRT---LQHRIA 1975
                ||||.:|..:.||::|.|:.....|..||:|||..|:|::||...:.:.|:.   :....|
 Worm  1764 YCTSRQELSLLSRMKHPNVIGLVGVCTFPLSLVVELAPLGALNQLLGSHRKAGTKLSLGVIKESA 1828

Human  1976 LHVADGLRYLHSAMIIYRDLKPHNVLLF----TLYPNAAIIAKIADYGIAQYCCRM-GIKTSEGT 2035
            :.||..|.|||||.|||||||..|||.:    ...|...::.|:.||||::..... |.|...||
 Worm  1829 VQVARALEYLHSAHIIYRDLKSENVLGWRFPAPFSPQTDVLLKLGDYGISRSVLPSGGAKGFGGT 1893

Human  2036 PGFRAPEVAR--GNVIYNQQADVYSFGLLLYDILTTGGRIVEGLKFPNEFD----ELEIQGKLPD 2094
            .||.|||:.|  |...|.|:.|.:|||:.||::||        ||||.|.:    |..:.|..|.
 Worm  1894 EGFMAPEIVRFNGEEEYTQKVDCFSFGMFLYELLT--------LKFPFESEEHVKERMLDGARPV 1950

Human  2095 PVKEYGCAPWPMVEKLIKQCLKENPQERPTSAQVFDILNSAEL-----VCLTRRILLPKNVIVEC 2154
            .:......|.||::.|: .|...:|:.||:|:|:.....:.|.     ||.....|.|..::...
 Worm  1951 LLPHELLLPTPMLDLLV-HCWSAHPESRPSSSQLVGFCAAPEFTHLLDVCELGEALPPTQLMAVG 2014

Human  2155 MV--ATHHNSRNASIWL--------GC---GHTDRGQLSFLDLNTEGYTSEEVADSRILC----- 2201
            :.  ....:...|.:||        ||   |..|:   ..::|...|....:|.||...|     
 Worm  2015 ITDEIDDPDDFEAQLWLSGREMVVMGCTQYGFVDQ---KSIELPHRGKYVSKVRDSVWSCDECGQ 2076

Human  2202 LALVHLPVEKESWIVSGTQSGTLL----------VINTEDGKKRHTLEKMTDSVTCLYCNSFSKQ 2256
            :.:..:.:.:...:...:.:|||:          :|...|  |:..|.|:::|      ||.|. 
 Worm  2077 VTVYGISLHETGHLQLPSLNGTLICAPELISNDVLILISD--KQIVLLKLSES------NSVSH- 2132

Human  2257 SKQKNFLLVGTADGKLAIFEDKTVKLKGAAPLKILNIGNVSTPLMCLSESTNSTERNVMWGG--- 2318
                    :||.|..   :|.:|...          :||.||              ..:|.|   
 Worm  2133 --------LGTIDSP---YEIRTATF----------LGNGST--------------RQIWAGHSE 2162

Human  2319 --------CGTKIFSFSNDF-------TIQKLIETRTSQLFSYAAFSDSNIITVVVDTALYIAKQ 2368
                    .....||||:..       .:::|:.::.:|                   .::||.:
 Worm  2163 GRISIHHIASNDSFSFSSSLYLPDDKCIVRQLVGSKDAQ-------------------KVWIALE 2208

Human  2369 NSPVVEVWDKKTEKLCGLIDCVHFLREVMVKENKESKH--KMSYSGRVKTLC---LQKNTA--LW 2426
            .|..|::.:.:..::.|.:|    :|:||  ...|:.|  .|..:.:....|   |::|..  |:
 Worm  2209 KSSKVQMVEVEKRQVTGSLD----IRKVM--PGSETIHTIDMEMASQNYVTCIGLLERNDGDQLY 2267

Human  2427 IGTGGGHILLLDLST 2441
            |||..|.:::...:|
 Worm  2268 IGTSKGLLVIAHATT 2282

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
LRRK2NP_940980.4 Required for RAB29-mediated activation. /evidence=ECO:0000269|PubMed:29212815, ECO:0000269|PubMed:38127736 1..969 124/729 (17%)
LRR 1. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 983..1004 6/20 (30%)
leucine-rich repeat 985..1012 CDD:275380 6/26 (23%)
LRR <1009..1279 CDD:443914 79/367 (22%)
LRR 2. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1012..1033 7/20 (35%)
leucine-rich repeat 1013..1036 CDD:275380 8/22 (36%)
LRR 3. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1036..1057 6/20 (30%)
leucine-rich repeat 1037..1084 CDD:275380 7/46 (15%)
LRR 4. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1059..1080 0/20 (0%)
LRR 5. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1084..1105 10/39 (26%)
leucine-rich repeat 1085..1108 CDD:275380 10/41 (24%)
LRR 6. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1108..1129 5/22 (23%)
leucine-rich repeat 1109..1130 CDD:275380 5/22 (23%)
LRR 7. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1130..1150 7/22 (32%)
leucine-rich repeat 1131..1174 CDD:275380 10/49 (20%)
LRR 8. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1156..1171 3/18 (17%)
LRR 9. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1174..1196 5/21 (24%)
leucine-rich repeat 1175..1197 CDD:275380 5/21 (24%)
LRR 10. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1197..1218 13/60 (22%)
leucine-rich repeat 1198..1221 CDD:275380 13/62 (21%)
LRR 11. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1221..1245 7/53 (13%)
leucine-rich repeat 1222..1246 CDD:275380 7/26 (27%)
LRR 12. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1246..1267 6/20 (30%)
leucine-rich repeat 1247..1269 CDD:275380 7/21 (33%)
LRR 13. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 1269..1291 6/21 (29%)
RocCOR 1334..1507 CDD:206741 60/197 (30%)
COR 1527..1740 CDD:406489 64/296 (22%)
STKc_LRRK2 1884..2135 CDD:270970 100/299 (33%)
WD 1. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2139..2183 10/56 (18%)
WD 2. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2188..2228 8/54 (15%)
WD 3. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2233..2276 10/42 (24%)
WD 4. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2281..2327 8/56 (14%)
WD 5. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2333..2377 6/43 (14%)
WD 6. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2402..2438 11/42 (26%)
WD 7. /evidence=ECO:0000269|PubMed:38127736, ECO:0007744|PDB:8FO2, ECO:0007744|PDB:8FO8, ECO:0007744|PDB:8FO9 2443..2497
lrk-1NP_492839.4 ANKYR 13..337 CDD:440430 67/379 (18%)
ANK repeat 56..88 CDD:293786 7/31 (23%)
ANK repeat 90..121 CDD:293786 1/30 (3%)
ANK repeat 197..228 CDD:293786 7/30 (23%)
ANK repeat 230..262 CDD:293786 5/33 (15%)
ANK repeat 361..390 CDD:293786 10/70 (14%)
Ank_2 366..472 CDD:463710 30/149 (20%)
ANK repeat 398..432 CDD:293786 6/34 (18%)
LRR <529..>778 CDD:443914 68/302 (23%)
leucine-rich repeat 534..555 CDD:275380 4/32 (13%)
leucine-rich repeat 556..580 CDD:275380 6/27 (22%)
leucine-rich repeat 581..604 CDD:275380 8/22 (36%)
leucine-rich repeat 605..627 CDD:275380 7/46 (15%)
leucine-rich repeat 628..654 CDD:275380 9/25 (36%)
leucine-rich repeat 655..684 CDD:275380 2/28 (7%)
leucine-rich repeat 687..718 CDD:275380 9/30 (30%)
leucine-rich repeat 719..742 CDD:275380 3/22 (14%)
leucine-rich repeat 743..765 CDD:275380 5/21 (24%)
leucine-rich repeat 803..856 CDD:275380 6/52 (12%)
LRR <857..>953 CDD:443914 26/96 (27%)
leucine-rich repeat 857..883 CDD:275380 7/26 (27%)
leucine-rich repeat 884..906 CDD:275380 7/21 (33%)
leucine-rich repeat 907..931 CDD:275380 8/23 (35%)
P-loop containing Nucleoside Triphosphate Hydrolases 977..1160 CDD:476819 58/192 (30%)
COR <1239..>1336 CDD:406489 32/104 (31%)
Protein Kinases, catalytic domain 1699..1990 CDD:473864 100/299 (33%)
Blue background indicates that the domain is not in the aligned region.

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