DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Bcl6 and CG10321

DIOPT Version :9

Sequence 1:NP_001334955.1 Gene:Bcl6 / 12053 MGIID:107187 Length:707 Species:Mus musculus
Sequence 2:NP_001261124.1 Gene:CG10321 / 37464 FlyBaseID:FBgn0034643 Length:855 Species:Drosophila melanogaster


Alignment Length:320 Identity:74/320 - (23%)
Similarity:116/320 - (36%) Gaps:53/320 - (16%)


- Green bases have known domain annotations that are detailed below.


Mouse   416 QPPMEPANLDLQS---PTKLSASGEDSTIPQASRLNNLV---------NRSLAGSPRSSSESHSP 468
            :||....::|:..   .::.|...:.....|:..|.|.|         ..:|.| |..:..|.||
  Fly   479 EPPDGETSVDIDQAFMDSEQSHHQQHQEEMQSISLENAVVEFSQATTTTEALVG-PTMTVSSASP 542

Mouse   469 LYMHPPKCTSCGSQSPQHT--EMCLH---TAGPTFPEEMG--------ETQSEYSDSSCENGTFF 520
            .   |.:......|.|...  |.|.|   .||.|...::.        :|.|..:.:..::.   
  Fly   543 T---PKRAKRSNHQIPAGVTLEPCDHQPPAAGSTTSSKLAAANSRQLVQTASVIAAAGADDN--- 601

Mouse   521 CNECDCRFSEEASLKRHTLQTHSDKPYKCDRCQASFRYKGNLASHKTVHTG------EKPYRCNI 579
             .|.|.....| .:::||....|.: |.|..|...||....|.:|...||.      :|..:|.|
  Fly   602 -YEIDANLVTE-FIRQHTSPLGSGR-YICHLCSTEFRQFKGLQNHMHSHTNWIRANCKKQPQCQI 663

Mouse   580 CGAQFNRPANLKTHTRIHSGEKPY-KCETCGARFVQVAHLRAHVLIHTGEKPYPCEI--CGTRFR 641
            |...|..|..|:.|.:.|..|... .|..|...|...|.|..|...|. ::.|.|.:  |...|.
  Fly   664 CLKSFKGPGMLRMHMKTHDAESSTPMCTICNRTFKSKAILYRHRQTHQ-QRAYCCGVANCRKNFS 727

Mouse   642 HLQTLKSHL-RIH--TGEKPYHCEKCNLHFRHKSQLRLHLRQKHGAITNTKVQYRVSAAD 698
            ....||.|: |.|  ..:..:.|.:|...:.:...|:||:..     |:...:.::|..|
  Fly   728 SAVNLKWHVERKHPEVVDPLFKCGECGSLYDNVDSLQLHVES-----TDHSAEVQISGQD 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Bcl6NP_001334955.1 BTB_POZ_ZBTB27_BCL6 8..125 CDD:349640
PHA03247 <179..429 CDD:223021 3/15 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 275..350
Required for interaction with NuRD complex and for transcriptional repressor activity 377..380
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 405..469 13/64 (20%)
C2H2 Zn finger 521..542 CDD:275368 5/20 (25%)
C2H2 Zn finger 549..569 CDD:275368 6/19 (32%)
zf-H2C2_2 561..586 CDD:372612 9/30 (30%)
C2H2 Zn finger 577..597 CDD:275368 7/19 (37%)
zf-H2C2_2 589..614 CDD:372612 7/25 (28%)
C2H2 Zn finger 605..625 CDD:275368 6/19 (32%)
zf-H2C2_2 617..642 CDD:372612 7/26 (27%)
C2H2 Zn finger 633..653 CDD:275368 7/22 (32%)
zf-H2C2_2 646..670 CDD:372612 7/26 (27%)
C2H2 Zn finger 661..679 CDD:275368 5/17 (29%)
CG10321NP_001261124.1 zf-AD 12..80 CDD:214871
ASF1_hist_chap <405..516 CDD:304562 6/36 (17%)
C2H2 Zn finger 627..647 CDD:275368 6/19 (32%)
C2H2 Zn finger 661..681 CDD:275368 7/19 (37%)
C2H2 Zn finger 690..710 CDD:275368 6/19 (32%)
C2H2 Zn finger 717..740 CDD:275368 7/22 (32%)
C2H2 Zn finger 750..767 CDD:275368 4/16 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24399
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.100

Return to query results.
Submit another query.