DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Bcl6 and Kr-h1

DIOPT Version :9

Sequence 1:	NP_001334955.1	Gene:	Bcl6 / 12053	MGIID:	107187	Length:	707	Species:	Mus musculus
Sequence 2:	NP_477466.1	Gene:	Kr-h1 / 33861	FlyBaseID:	FBgn0266450	Length:	845	Species:	Drosophila melanogaster

Alignment Length:	427	Identity:	117/427 - (27%)
Similarity:	169/427 - (39%)	Gaps:	97/427 - (22%)

- Green bases have known domain annotations that are detailed below.

Mouse   333 QSPQKSDCQPNSPTESCS-------SKNACILQASGS----------PPAKSPTDPKACNWKKYK 380
            :||.|:.....||.:..:       |.|..:::...|          ||..:.|
  Fly    34 KSPAKAVAVKKSPAKDSATTKMVYYSANQLLIKTEQSSQAQFCLQVPPPLTATT----------- 87

Mouse   381 FIVLNSLNQNAKPEGSEQAELGRLSPRAYPAPPACQPPMEPAN-----------LDLQSPTKLSA 434
                .|:.....|.|.:|.....|..   |.....|..::..:           |.:|...|...
  Fly    88 ----TSVGLGVPPSGGQQEHFELLQT---PQQRQMQLQLQDQHQQEQQQFVSYQLAIQQHQKQQQ 145

Mouse   435 SGEDSTI--------PQASRLNNLVNRSLAGSPRSS---SESHSPLYMHPP-KCTSCG------S 481
            ..:..:|        |.|.|:.   ...:.|.|.|:   |:...|....|. ||..||      |
  Fly   146 QQQHESITNAAPTAAPSAQRIK---TEPVGGFPASAAVVSQVRKPSASKPQFKCDQCGMTFGSKS 207

Mouse   482 QSPQHT-------EMCLHTA-GPTFPEEMGETQSEYSDSSCENG------------------TFF 520
            ....||       ::.|:.| |......:.....|.:|:....|                  .:.
  Fly   208 AHTSHTKSHSKNQDLSLNGASGAGVAAPVSTAAIELNDAGLPVGIPKSPTIKPLANVAAGADPYQ 272

Mouse   521 CNECDCRFSEEASLKRHTLQTHS-DKPYKCDRCQASFRYKGNLASHKTVHTGEKPYRCNICGAQF 584
            ||.|...|:..|.|.|| .:||: ::|::|:.|...|..|.||..|:.:||.|:||:|::||..|
  Fly   273 CNVCQKTFAVPARLIRH-YRTHTGERPFECEFCHKLFSVKENLQVHRRIHTKERPYKCDVCGRAF 336

Mouse   585 NRPANLKTHTRIHSGEKPYKCETCGARFVQVAHLRAHVLIHTGEKPYPCEI--CGTRFRHLQTLK 647
            .....|..|.|||:||:|:||..|...|:|...|..|:..|||||||.|..  ||..|...:.||
  Fly   337 EHSGKLHRHMRIHTGERPHKCSVCEKTFIQSGQLVIHMRTHTGEKPYKCPEPGCGKGFTCSKQLK 401

Mouse   648 SHLRIHTGEKPYHCEKCNLHFRHKSQLRLHLRQKHGA 684
            .|.|.|||||||||:.|...|.:...|:||..|.:|:
  Fly   402 VHSRTHTGEKPYHCDICFRDFGYNHVLKLHRVQHYGS 438

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Bcl6	NP_001334955.1	BTB_POZ_ZBTB27_BCL6	8..125	CDD:349640
		PHA03247	<179..429	CDD:223021	20/123 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	275..350		5/16 (31%)
		Required for interaction with NuRD complex and for transcriptional repressor activity	377..380		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	405..469		13/85 (15%)
		C2H2 Zn finger	521..542	CDD:275368	8/20 (40%)
		C2H2 Zn finger	549..569	CDD:275368	7/19 (37%)
		zf-H2C2_2	561..586	CDD:372612	12/24 (50%)
		C2H2 Zn finger	577..597	CDD:275368	7/19 (37%)
		zf-H2C2_2	589..614	CDD:372612	12/24 (50%)
		C2H2 Zn finger	605..625	CDD:275368	6/19 (32%)
		zf-H2C2_2	617..642	CDD:372612	13/26 (50%)
		C2H2 Zn finger	633..653	CDD:275368	8/21 (38%)
		zf-H2C2_2	646..670	CDD:372612	15/23 (65%)
		C2H2 Zn finger	661..679	CDD:275368	6/17 (35%)
Kr-h1	NP_477466.1	C2H2 Zn finger	196..216	CDD:275368	6/19 (32%)
		COG5048	<270..420	CDD:227381	67/150 (45%)
		zf-C2H2	271..293	CDD:278523	8/22 (36%)
		C2H2 Zn finger	273..293	CDD:275368	8/20 (40%)
		zf-H2C2_2	286..309	CDD:290200	8/23 (35%)
		C2H2 Zn finger	301..321	CDD:275368	7/19 (37%)
		zf-H2C2_2	313..338	CDD:290200	12/24 (50%)
		C2H2 Zn finger	329..349	CDD:275368	7/19 (37%)
		zf-H2C2_2	344..366	CDD:290200	11/21 (52%)
		C2H2 Zn finger	357..377	CDD:275368	6/19 (32%)
		zf-H2C2_2	370..396	CDD:290200	13/25 (52%)
		C2H2 Zn finger	385..407	CDD:275368	8/21 (38%)
		zf-H2C2_2	400..424	CDD:290200	15/23 (65%)
		C2H2 Zn finger	415..435	CDD:275368	6/19 (32%)
		zf-C2H2	441..463	CDD:278523
		C2H2 Zn finger	443..463	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910