DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SLC36A4 and CG32081

DIOPT Version :9

Sequence 1:	NP_689526.2	Gene:	SLC36A4 / 120103	HGNCID:	19660	Length:	504	Species:	Homo sapiens
Sequence 2:	NP_729646.1	Gene:	CG32081 / 326194	FlyBaseID:	FBgn0052081	Length:	471	Species:	Drosophila melanogaster

Alignment Length:	477	Identity:	137/477 - (28%)
Similarity:	228/477 - (47%)	Gaps:	72/477 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    59 ISFVQTLMHLLKGNIGTGLLGLPLAIKNAGIVLGPISLVFIGIISVHCMHILVRCSHFLCLRFKK 123
            ||.:.....|||..:|||::.:||:...||||.|.|.||.:..:.:|.|.:|:.|. ..|.|  :
  Fly    19 ISDIGAFFSLLKCVVGTGVMAIPLSFNYAGIVTGIILLVSVCFMLIHGMQMLIICM-IECSR--R 80

Human   124 STLGYSD---TVSFAMEVSP--WSCLQKQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHE 183
            ..:||:.   .:.::.:..|  :..:.|.   ||.:||..|..:|.|.|.||.||:|..:||:.:
  Fly    81 MQIGYATYPVAMVYSFDQGPRFFKYISKA---GRYIVDGVLAFSQFGVCVVYNVFVAATLKQLVD 142

Human   184 GFLESKVFISNSTNSSNPCERRSVDLRIYM----LCFLPFIILLVF-IRELKNLFVLSFLANVSM 243
            .:..                  ..|||||:    ||.:|     .| ||:||.|...:.||::.:
  Fly   143 FYWV------------------VADLRIYIAVIALCLIP-----PFQIRKLKYLVPFNILASILI 184

Human   244 AVSLVIIYQYVVRNMPDPHNLPIVAG-WKKYPLFFGTAVFAFEGIGVVLPLENQMKESKRFP--- 304
            .....::..|:..::|......|:.| ..|.|||||.|:|:...:||:|.:|..|.:.:.:.
  Fly   185 YTGFSLMMYYLFVDLPPITERNILFGRIDKIPLFFGIALFSITSVGVMLAVEATMAKPRHYLGWF 249

Human   305 QALNIGMGIVTTLYVTLATLGYMCFHDEIKGSITLNLPQDVWLYQSVKILYSFGIFVTYSIQFYV 369
            ..|:..:.:|...|||...:||..:.||..|||:||:|.|..|.|..|...:..||:||.:..:|
  Fly   250 GILDRAILLVIISYVTFGLMGYWRYGDETAGSISLNIPTDEVLSQVAKGFIAAAIFLTYPLAGFV 314

Human   370 PAEII----------IPGITSKFHTKWKQICEFGIRSFLVSITCAGAILIPRLDIVISFVGAVSS 424
            ..:||          :|....|         |..:|:..|.:.|..||:.|.|..::|.|||::.
  Fly   315 IIDIIMNHFWNKNGDLPNAALK---------ESILRACTVVLICITAIIAPNLGPLLSLVGALTI 370

Human   425 STLALILPPLVEILTFSKEHYNI----WMVLKNISIAFTGVVGFLLGTYITVEEII--YPTPKVV 483
            |.|.|:.|.|:||..:....||.    |:::|:|.....|::..:.||..:::::|  :......
  Fly   371 SLLNLVFPALIEICLYYPPEYNYGKLKWVLVKDIFYVIVGILILVQGTVFSIKDMISEWGGGDTT 435

Human   484 AGTPQS----PFLNLNSTCLTS 501
            .|.|::    ...|:::|..|:
  Fly   436 TGGPETTAEETTANMSATLTTA 457

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SLC36A4	NP_689526.2	SLC5-6-like_sbd	58..476	CDD:294310	131/444 (30%)
CG32081	NP_729646.1	SLC5-6-like_sbd	17..422	CDD:294310	131/440 (30%)
CG32081	NP_729646.1	SdaC	20..415	CDD:223884	128/432 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158594
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D284074at33208
OrthoFinder	1	1.000	-	-		FOG0000138
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR22950
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.940