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Protein Alignment CLN3 and Cln3

DIOPT Version :9

Sequence 1:	NP_000077.1	Gene:	CLN3 / 1201	HGNCID:	2074	Length:	438	Species:	Homo sapiens
Sequence 2:	NP_001261999.1	Gene:	Cln3 / 39981	FlyBaseID:	FBgn0036756	Length:	422	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	173/408 - (42%)
Similarity:	252/408 - (61%)	Gaps:	34/408 - (8%)

- Green bases have known domain annotations that are detailed below.

Human    35 WKNAVGFWLLGLCNNFSYVVMLSAAHDILSHKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAA 99
            |::...:|:||||||:.|||||||||||:...           .|......|||..:|:.|||.|
  Fly    35 WRDLTSYWILGLCNNYGYVVMLSAAHDIIKQF-----------NPNDESEESSSGRNCHLVSTGA 88

Human   100 VLLADILPTLVIKLLAPLGLHLLPYSP-----RVLVSGICAAGSFVLVAFSHSVGTSLCGVVFAS 159
            :||||:||:|.:|:       |:|:.|     |:.::...:|..|:||.|:::...:|.||:..|
  Fly    89 ILLADVLPSLFVKI-------LMPFFPFWVNFRIALAVAFSAAGFLLVGFANAEWMALLGVIITS 146

Human   160 ISSGLGEVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQAGLSPQQTLLSMLGIPALLL 224
            .|||:||.|||:.::.|.:.|||.|||||||||::|:|||..|.....||:.|:|.||..||:..
  Fly   147 ASSGIGETTFLAYSSRYNKNVISTWSSGTGGAGVIGSLSYASLRSLDFSPRDTMLIMLIFPAIEA 211

Human   225 ASYFLLLTSPEAQDPGGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERWTVFKGLLWYIVPLV 289
            .:::|||..|:. |.......||.  :.||..|.|        .:..:|:....|.|..|::||.
  Fly   212 FAFWLLLRRPQV-DILPVTTVEST--EVLISDEKP--------LVGFKEKLFYIKHLFKYMLPLC 265

Human   290 VVYFAEYFINQGLFELLFFWNTSLSHAQQYRWYQMLYQAGVFASRSSLRCCRIRFTWALALLQCL 354
            :|||.|||||||||||::|.:..|....||||..:.||.|||.||||:...::...|.:::.|.:
  Fly   266 LVYFFEYFINQGLFELVYFEDIFLDKDSQYRWLNVDYQIGVFISRSSVNLFQLDKIWLMSIFQFV 330

Human   355 NLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTFHNIALETSDEHREFAMAATCISDTLG 419
            |:|:.|.:|.:.:.|||::||.|:|:||||||.||||||:.::.|.|.|.::||||....||:.|
  Fly   331 NVVYFLTEVIWWYTPSIWIVFAIVLWEGLLGGGAYVNTFYRMSKEISPERQQFAMAMVVQSDSYG 395

Human   420 ISLSGLLALPLHDFLCQL 437
            |:|:|.||:|:|:.:|.|
  Fly   396 IALAGFLAIPVHNAICGL 413

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.