Protein Alignment CLN3 and cln-3.3

DIOPT Version :10

• Sequence 1: XP_054170579.1
• Gene: CLN3 / 1201
• HGNCID: 2074
• Length: 489
• Species: Homo sapiens
• Sequence 2: NP_505237.1
• Gene: cln-3.3 / 179249
• WormBaseID: WBGene00000541
• Length: 417
• Species: Caenorhabditis elegans
• Alignment Length: 423
• Identity: 171/423 - (40%)
• Similarity: 246/423 - (58%)
• Gaps: 49/423 - (11%)

Human    89 AVGFWLLGLCNNFSYVVMLSAAHDILS--HKRTSGNQSHVDPGPTPIPHNSSSRFDCNSVSTAAV 151
            ||.|:|:|||||:.||:|||||.||||  |.:...|       .|.:...:.::.:|.. ..|.|
 Worm    13 AVAFFLIGLCNNYGYVIMLSAAEDILSEQHGKVKSN-------ATDLCLPAITKRECKP-PVAEV 69

Human   152 LLADILPTLVIKLLAPLGLHLLPYSPRVLVSGICAAGSFVLVAFSHSVGTSLCGVVFASISSGLG 216
            ||:|.||:|::||..|..:...|:..||.:..:..|.|:.:||||.|:..||.||||.|:..|||
 Worm    70 LLSDNLPSLIVKLTFPFFMDRFPFGFRVAIVCLLQATSYFVVAFSVSIPMSLAGVVFVSLGGGLG 134

Human   217 EVTFLSLTAFYPRAVISWWSSGTGGAGLLGALSYLGLTQ---AGLSPQQTLLSMLGIPALLLASY 278
            |:|||.|:|.|.|..|:.||||||.|||||:.||..||:   |.|:|:..||..|.||.|...:|
 Worm   135 EITFLGLSAHYQRIAIAGWSSGTGMAGLLGSFSYAFLTEPHMANLTPKVALLIQLFIPVLFAFAY 199

Human   279 FLLLTSPEA-----QDP-------GGEEEAESAARQPLIRTEAPESKPGSSSSLSLRERWTVFKG 331
            |:||..||:     .||       |.::...|..|       .|:.:.|.|..|.|      ...
 Worm   200 FILLKKPESVYSPTLDPKSWIVPKGYDDFIVSEHR-------VPQRELGPSDRLKL------ILP 251

Human   332 LLWYIVPLVVVYFAEYFINQGLFELLFF-----WNTSLSHAQQYRWYQMLYQAGVFASRSSLRCC 391
            :|..::||.:||..||.||||:.:.:.|     :|.|| |: ||||||:|||.|||.||||:|..
 Worm   252 MLHLMIPLAIVYVGEYMINQGMTQQIVFDCAHGFNLSL-HS-QYRWYQVLYQFGVFVSRSSIRLV 314

Human   392 RIRFTWALAL---LQCLNLVFLLADVWFGFLPSIYLVFLIILYEGLLGGAAYVNTFHNIALETSD 453
            .:.. |.|.|   ||..|::|...|..:.|:|.|.::|.:|::|||.||::||||||.|..:...
 Worm   315 ELPM-WMLYLLPFLQLTNMLFFFFDALYWFVPQIAIIFALIIFEGLFGGSSYVNTFHKIHNKVEP 378

Human   454 EHREFAMAATCISDTLGISLSGLLALPLHDFLC 486
            :.||:.::|..:.|::|::.:..:::|||.::|
 Worm   379 DVREYCLSAASMGDSIGVNFAAGVSIPLHYWMC 411

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLN3	XP_054170579.1	CLN3	90..488	CDD:460570	170/422 (40%)
cln-3.3	NP_505237.1	CLN3	14..412	CDD:460570	170/422 (40%)