Protein Alignment ADD3 and add3a

DIOPT Version :10

• Sequence 1: NP_058432.1
• Gene: ADD3 / 120
• HGNCID: 245
• Length: 706
• Species: Homo sapiens
• Sequence 2: NP_001428998.1
• Gene: add3a / 556762
• ZFINID: ZDB-GENE-030131-2721
• Length: 678
• Species: Danio rerio
• Alignment Length: 711
• Identity: 479/711 - (67%)
• Similarity: 580/711 - (81%)
• Gaps: 38/711 - (5%)

Human     1 MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSP 65
            ||.:..|.|:|||||||:..:|.||||:|||||||:|.||||||||||||||||:||||||||||
Zfish     1 MSGEPRQEVVTTPPPPSVGKREGYFDRVNENDPEYLRARNMSPDLRQDFNMMEQKKRVTQILQSP 65

Human    66 AFREDLECLIQEQMKKGHNPTGLLALQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSY 130
            ||:::||.:|||||.||:||||||||:||||:.|::|.:|||:.||||||||||||:...::|:.
Zfish    66 AFKDELEGMIQEQMNKGNNPTGLLALRQIADFFMSSSVAGFSTSPLSLGMVTPINDMFSVESSTM 130

Human   131 VKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNII 195
            |||||.||||||||||:||||.|||.|:.||:||:|||||||:||||||||:||:|||||||||:
Zfish   131 VKGEKQTRCKLASLYRIVDLFSWAHFASCYITVRVSKEQDHILIIPRGLSFAEASASNLVKVNIL 195

Human   196 GEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDV 260
            |:|:|||||||:||..||||||||||.||||:|::||.|.|||||||||||:||||||:|:|||:
Zfish   196 GDVIDQGSTNLRIDAAGFSPHAAIYSIRPDVRCIVHISTPATAAVSSMKCGLLPISQEALILGDI 260

Human   261 AYYDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALA 325
            |||:|||||:|||||::|||.|||:.|||||||||:||||||:|||||||:..|.||||||.|.:
Zfish   261 AYYNYQGSLDEQEERVELQKALGPTAKVLVLRNHGIVALGETIEEAFHYIYGAQYACEIQVNAFS 325

Human   326 GAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYR 390
            .|||::||.|||.:|:||.|..||..   ||||||.|||::||:|||.|||.||||||||||.||
Zfish   326 CAGGMENLIVLDLEKFKARTQGVAQV---GVNMGSQQKWRLGELEFESLMRMLDNLGYRTGYTYR 387

Human   391 HPLIREKPRHKSDVEIPATVTAFSFEDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEES 455
            ||::||||||||:||||||||||.|::|..|..|||.:.|||||||||||||||.||||||.:.:
Zfish   388 HPIVREKPRHKSEVEIPATVTAFMFDEDDAPRFPLKLLQQRQQREKTRWLNSPNCYMKVNVADGA 452

Human   456 RNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAG 520
              .|.:.|||.||||::|....| ||||:||||||||||||||:|||:||||||||||:|:.|||
Zfish   453 --SEENRRTKTTWMKSDDGGNAS-GTPIRIEDPNQFVPLNTNPSEVLQKRNKIREQNRFDVMTAG 514

Human   521 PQSQLLAGIVVDKPPSTMQFE-----DDDHGPPAPPNPFSHLTEGELEEYKRTIERKQQGLEDAE 580
            ||||.||||||::||.....:     |::...|.||||||.|  .|.||::|.:.     ::..|
Zfish   515 PQSQKLAGIVVERPPGQSPVQPYMGNDEEETGPLPPNPFSEL--NEKEEHQRRLR-----IDADE 572

Human   581 QELLSDDASSVSQIQSQTQSPQNVPEKLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKR 645
            ::|.|||||::    ||:.|||:.|.| ||||            ..:::||||| |..||||.||
Zfish   573 EQLTSDDASTL----SQSVSPQHTPAK-EENH------------TGVMLNGKDD-HGDEDELIKR 619

Human   646 VSRLSTSTTIENIEITIKSPEKIEEVLSPEGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA 706
            ||:|:||  :|::||:::|.|||||.|:||.||||||:|||||||||||||||||||||||
Zfish   620 VSQLTTS--LESMEISVRSGEKIEEALTPESSPSKSPNKKKKKFRTPSFLKKNKKKEKVEA 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADD3	NP_058432.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		11/18 (61%)
		Aldolase_II	137..385	CDD:469663	184/247 (74%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..497		17/25 (68%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..555		7/24 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	575..610		14/34 (41%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	666..706		35/39 (90%)
		Interaction with calmodulin. /evidence=ECO:0000255	684..701		16/16 (100%)
add3a	NP_001428998.1	None