Protein Alignment ADD3 and add3

DIOPT Version :10

• Sequence 1: NP_058432.1
• Gene: ADD3 / 120
• HGNCID: 245
• Length: 706
• Species: Homo sapiens
• Sequence 2: NP_001006858.2
• Gene: add3 / 448622
• XenbaseID: XB-GENE-5923007
• Length: 685
• Species: Xenopus tropicalis
• Alignment Length: 710
• Identity: 497/710 - (70%)
• Similarity: 577/710 - (81%)
• Gaps: 29/710 - (4%)

Human     1 MSSDASQGVITTPPPPSMPHKERYFDRINENDPEYIRERNMSPDLRQDFNMMEQRKRVTQILQSP 65
            |:|..||||||.||.|||||||||||||:||||.|:||||||||||||||||||:|||||:|:||
 Frog     1 MTSALSQGVITAPPLPSMPHKERYFDRIDENDPSYLRERNMSPDLRQDFNMMEQKKRVTQMLKSP 65

Human    66 AFREDLECLIQEQMKKGHNPTGLLALQQIADYIMANSFSGFSSPPLSLGMVTPINDLPGADTSSY 130
            |||:|||.||||||.||:.||.|||||||:|||||:||||.|    .|| |.||||:..|..::.
 Frog    66 AFRDDLETLIQEQMNKGNTPTELLALQQISDYIMASSFSGSS----QLG-VAPINDIHPAMEATM 125

Human   131 VKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHIIIIPRGLSFSEATASNLVKVNII 195
            .|||:||||||||:|||.||||||:||..||:||::||||||:|:|||||||||:||||||:|||
 Frog   126 AKGERLTRCKLASMYRLADLFGWAYLAKAYITVRVTKEQDHILIMPRGLSFSEASASNLVKLNII 190

Human   196 GEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATAAVSSMKCGILPISQESLLLGDV 260
            ||||:||||||:||.:|||||||||:|||||:|.|||||.|.||||||||||||||||:||||||
 Frog   191 GEVVEQGSTNLQIDPSGFSPHAAIYATRPDVRCAIHIHTPAAAAVSSMKCGILPISQEALLLGDV 255

Human   261 AYYDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGVVALGETLEEAFHYIFNVQLACEIQVQALA 325
            |||:|||||:||||||:||||||.|.||||||||||:||||:||||||||||||||||:||.|||
 Frog   256 AYYNYQGSLDEQEERIELQKVLGASAKVLVLRNHGVLALGESLEEAFHYIFNVQLACEVQVHALA 320

Human   326 GAGGVDNLHVLDFQKYKAFTYTVAASGGGGVNMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYR 390
            |||||:||.:||.:|:|..||.|||:|||||||....||||||:|||.|||.|||||||||||||
 Frog   321 GAGGVNNLLLLDLEKFKPTTYCVAAAGGGGVNMEGDHKWKVGELEFESLMRMLDNLGYRTGYAYR 385

Human   391 HPLIREKPRHKSDVEIPATVTAFSF-EDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEE 454
            .||.||.||||||||||||||||:| ||.|:..|||:.:||:||||||||||||||||:|:|||.
 Frog   386 RPLTRENPRHKSDVEIPATVTAFTFDEDPTMQQSPLRLLAQKQQREKTRWLNSPNTYMRVHVPEA 450

Human   455 SRNGETSPRTKITWMKAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTA 519
            |.:||.||||||.|||||...|.|.|.||||||||||||:||||..||:.|||||||||:|||||
 Frog   451 SFSGEMSPRTKIMWMKAEQQDKTSSGFPIKIEDPNQFVPMNTNPTHVLQTRNKIREQNRFDLKTA 515

Human   520 GPQSQLLAGIVVDKPPSTMQFEDDDHGPPAPPNPFSHLTEGELEEYKRTIERKQQGLE--DAEQE 582
            |||||.|:|||||||.....|.:|::.||.||||||.|    |||     |::..|.|  |||.|
 Frog   516 GPQSQYLSGIVVDKPSPPYHFVEDENAPPLPPNPFSQL----LEE-----EKEGMGKENLDAEPE 571

Human   583 LLSDDASSVSQIQSQTQSPQNVPEKLEENHELFSKSFISMEVPVMVVNGKDDMHDVEDELAKRVS 647
            |..:||:.::..||..|:|....|.:.|       ..:.:|.|.:|:|||:. .:..:||:.:|.
 Frog   572 LTPEDAAPIATPQSPPQTPITSKEHVLE-------FMLQLESPPVVLNGKES-GEHREELSVQVG 628

Human   648 RLSTSTTIENIEITIKSPEK-IEEVLSPEGSPSKSPSKKKKKFRTPSFLKKNKKKEKVEA 706
            :||..   |.:|||::..:| ||..|:||||||||||||||||||||||||||||||:||
 Frog   629 QLSVG---ETVEITVRPSDKIIEGELTPEGSPSKSPSKKKKKFRTPSFLKKNKKKEKLEA 685

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADD3	NP_058432.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..20		13/18 (72%)
		Aldolase_II	137..385	CDD:469663	199/247 (81%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	471..497		18/25 (72%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	535..555		8/19 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	575..610		14/36 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	666..706		34/40 (85%)
		Interaction with calmodulin. /evidence=ECO:0000255	684..701		16/16 (100%)
add3	NP_001006858.2	GerD	<31..80	CDD:436127	41/48 (85%)
		Aldolase_II	123..380	CDD:469663	203/256 (79%)