DRSC/TRiP Functional Genomics Resources

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Protein Alignment ADD3 and hts

DIOPT Version :10

Sequence 1:NP_058432.1 Gene:ADD3 / 120 HGNCID:245 Length:706 Species:Homo sapiens
Sequence 2:NP_001097377.2 Gene:hts / 37230 FlyBaseID:FBgn0263391 Length:1833 Species:Drosophila melanogaster


Alignment Length:695 Identity:246/695 - (35%)
Similarity:370/695 - (53%) Gaps:87/695 - (12%)


- Green bases have known domain annotations that are detailed below.


Human    44 DLRQDFNMMEQRKRVTQILQSPAFREDLECLIQEQMKKGHNPTGLLALQQIADYIMANSFSGFSS 108
            |:.||...||:||||..|:.|..|||:||.::......|...:|:  |||::| |:....|...|
  Fly    29 DIEQDMREMERRKRVEAIMGSKLFREELERIVDSARDGGAGASGI--LQQLSD-IVGVPVSRVGS 90

Human   109 PPLSLGMVTPINDLPGADTSSYVKGEKLTRCKLASLYRLVDLFGWAHLANTYISVRISKEQDHII 173
            ...|...:.||||:.|.::..|.||||:.|||||:.:||:||:||.......|:.|:..:|::.:
  Fly    91 VFKSSNCMVPINDIRGVESMGYAKGEKILRCKLAATFRLLDLYGWTQGLGAQITARLKVDQEYFL 155

Human   174 IIPRGLSFSEATASNLVKVNIIGEVVDQGSTNLKIDHTGFSPHAAIYSTRPDVKCVIHIHTLATA 238
            :.|.||.:.|.|||.|.||::.|::|:||:||...:.:.|..|:.:::.|||::|.|:|......
  Fly   156 VNPYGLLYHEITASALNKVDMQGQIVEQGTTNFGGNKSHFVLHSVVHAARPDIRCAIYIGCSPVV 220

Human   239 AVSSMKCGILPISQESLLLGDVAYYDYQGSLEEQEERIQLQKVLGPSCKVLVLRNHGVVALGETL 303
            |:||:|.|:||:::::.:||::..:.|.| |.::|||.:|.:.|||:.||::|.|||.:..|||:
  Fly   221 AISSLKTGLLPLTKDACVLGEITTHAYTG-LFDEEERNRLVRSLGPNSKVILLTNHGALCCGETI 284

Human   304 EEAFHYIFNVQLACEIQVQALAGAGGVDNLHVLDFQKYKA---------------FTYTVAASGG 353
            ||||....::..|||.|::.|  ..|:|||.::..:..||               |....||..|
  Fly   285 EEAFFAACHIVQACETQLKLL--PVGLDNLVLIPEESRKAIYEQSRRPPEDLEKKFAAVAAAEDG 347

Human   354 GGV----------NMGSHQKWKVGEIEFEGLMRTLDNLGYRTGYAYRHPLIR-EKPRHKSDVEIP 407
            ...          .:||..||:||..|||.|||.|||.||||||.||||||: :.|:.|:|||:|
  Fly   348 AATAEKDAAEAVPKVGSPPKWRVGGAEFEALMRMLDNAGYRTGYIYRHPLIKSDPPKPKNDVELP 412

Human   408 ATVTAFSF---EDDTVPLSPLKYMAQRQQREKTRWLNSPNTYMKVNVPEESRNGETSPRTKITWM 469
            ..|::..:   |::.......|....|:..:::|||||||.|.||.|.|   .|...|: |||..
  Fly   413 PAVSSLGYLLEEEELFRQGIWKKGDIRKGGDRSRWLNSPNVYQKVEVLE---TGTPDPK-KITKW 473

Human   470 KAEDSSKVSGGTPIKIEDPNQFVPLNTNPNEVLEKRNKIREQNRYDLKTAGPQSQLLAGIVVD-- 532
            .||.|...|  ||::||||.||||..|||.|....:..|::..|.|..:|||||.:|.|:..|  
  Fly   474 VAEGSPTHS--TPVRIEDPLQFVPAGTNPREFKRVQQLIKDNRRADKISAGPQSHILEGVTWDEA 536

Human   533 ---KPPSTMQFEDD----------------DHG-----PPAPPNPFSHLTEGELEEYKRTIERKQ 573
               |..:..|..|.                .|.     .|...|||.::|:.||.|||||:|||:
  Fly   537 SRLKDATVSQAGDHVVMMGAASKGIIQRGFQHNATVYKAPYAKNPFDNVTDDELNEYKRTVERKK 601

Human   574 QGLEDAEQELLSDDASSVSQIQSQTQS-PQNVPEKLEENHELFSKSFISMEVP--VMVVNGKDDM 635
            :.:.....:  :|.:.|.:.:|:.|:. ||:.|   |..|::.........||  ..||...||.
  Fly   602 KSVHGEYTD--TDFSESEAVLQAGTKKYPQSEP---ETEHQVIEIQTQQAPVPRQAEVVLSDDDS 661

Human   636 ------HDVEDELAKRVSRLSTSTTIENIEITIK------SPEKI 668
                  .|:|::|.:|...:..::.........|      |||::
  Fly   662 KNNEYGDDMENQLYERNRNVHNNSKCRRDLFATKRRDPHPSPERL 706

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
ADD3NP_058432.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..20
Aldolase_II 137..385 CDD:469663 102/272 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 471..497 14/25 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 535..555 6/40 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 575..610 7/35 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 666..706 1/3 (33%)
Interaction with calmodulin. /evidence=ECO:0000255 684..701
htsNP_001097377.2 Aldolase_II 116..323 CDD:238232 82/209 (39%)
Blue background indicates that the domain is not in the aligned region.

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