Protein Alignment SERPINA3 and Spn38F

DIOPT Version :10

• Sequence 1: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_524956.2
• Gene: Spn38F / 49806
• FlyBaseID: FBgn0028986
• Length: 372
• Species: Drosophila melanogaster
• Alignment Length: 375
• Identity: 122/375 - (32%)
• Similarity: 189/375 - (50%)
• Gaps: 19/375 - (5%)

Human    51 SANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEI 115
            |.:..|...||:.|..:..|||:|.||||:..||:...:||...|..|:...||.   ...:.|:
  Fly    12 SVSCRFTDDLYQLLAKENADKNLITSPLSVEIALSLAYMGARGKTAQEMRDVLKL---PDDKKEV 73

Human   116 HQSFQHLLRTLNQSSDELQLSMGNAMFVKEQLSLLDRFTEDAKRLYGSEAFATDFQDSAAAKKLI 180
            ...|:.||..|........||:.|.::|..:..|:..:.:..|..:.:||.|....:......::
  Fly    74 AAKFKDLLSKLEGRESVAILSLANRIYVNNKFKLVPEYNQMVKDSFKAEAEAISANNPKITASIV 138

Human   181 NDYVKNGTRGKITDLIKDLD-SQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFYLSKKKWVMVPMM 244
            |.:|...|.|||.||:...| :..::|::|.|:||.:|:..|:.:.| :|.|::|.:|.|.|.||
  Fly   139 NKWVDTQTSGKIRDLVMPSDVANLVLVILNAIYFKGQWQKKFNTEQT-KSDFHISDQKSVPVQMM 202

Human   245 SL-HHLTIPYFRDEELSCTVVELKY-TGNASALFILPDQ-DKMEEVEAMLLPETLKRWRDSLEFR 306
            || ....:.|  |.||...|:||.| ..|.|.:..|||: |.:.|:|..::..|.|....::..|
  Fly   203 SLVRPFGVSY--DRELGANVIELPYRNSNLSMVIFLPDKVDGLPELEKKMVGFTPKLININVHLR 265

Human   307 EIGELYLPKFSISRDYNLNDILLQLGIEEAFTSKADLSGITGARNLAVSQVVHKAVLDVFEEGTE 371
                  ||||.|.....|..:|:.:||::||.:.||.:.:.......|..|||||.|:|.|||:|
  Fly   266 ------LPKFKIEFSARLEQVLIAMGIQDAFKTSADFNDLVANSGAHVGGVVHKAFLEVNEEGSE 324

Human   372 ASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPK 421
            |:||||| :....::.........|.||..:|  .|.:||:|.....||:
  Fly   325 AAAATAV-VFRYKSIRSPPMDFNVNHPFAYVI--RDAENIYFQGHFVNPE 371

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	121/373 (32%)
		RCL	369..394		8/24 (33%)
		O-glycosylated at one site	381..389		0/7 (0%)
Spn38F	NP_524956.2	serpin42Dd-like_insects	12..370	CDD:381070	120/372 (32%)