Protein Alignment SERPINA3 and Spn77Bb

DIOPT Version :10

• Sequence 1: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_649206.1
• Gene: Spn77Bb / 40235
• FlyBaseID: FBgn0036969
• Length: 362
• Species: Drosophila melanogaster
• Alignment Length: 361
• Identity: 76/361 - (21%)
• Similarity: 137/361 - (37%)
• Gaps: 60/361 - (16%)

Human    84 LAFLSL-----------GAHNTTLTEILKGLKFNLTETSEAEIHQSFQ--HLLRTLNQSSDELQL 135
            |.||.|           ||...|:.|:...|...:...:....::..:  |.|.:.|.....|:.
  Fly     3 LGFLGLFGMVLMIMFYEGAEGYTVNELRDVLGIYVDYPTLRRWYEDVRAYHYLNSENTKLFSLRY 67

Human   136 S----MGNAMFVKEQLS-LLDRFTEDAKRLYGSEAFATDFQDSAAAKKLINDYVKNGTRGKITDL 195
            :    :|:...||...| :|:...|....|........||...|:.  :|||.:...:..||...
  Fly    68 AYYDDVGDLELVKGYNSVVLEGVGEGNVVLREGRPRGVDFDQGASI--IINDDIDKASHAKIFSS 130

Human   196 I--KDLDSQTMMVLVNYIFFKAKWEMPFDPQDTHQSRFY-----LSKKKWVMVPMMSLHHLTIPY 253
            .  :..:|...::.:...:|||||:.|||...|...:||     .:.|..:||......::.
  Fly   131 YSRRSFNSTVTVLGITVSYFKAKWKYPFDKSQTKVEQFYNDGGSPAGKVEMMVQTGKYAYVN--- 192

Human   254 FRDEELSCTVVELKYTGNASALFI-LPDQDK-----MEEVEAMLLPETLKRWRDSLEFREIGELY 312
             ..:.|...|:||.:..:...:.: ||...:     :.:::.:.|...|::...|....:: |:.
  Fly   193 -NVKGLQADVLELPFGEHELVMIVLLPKSSQGVNLVLYQLKNLGLHRLLEKLEASKNETDV-EVK 255

Human   313 LPKFSISRDYNLNDILLQLGIEEAFTSKADLSGI---TGARNLAVSQVVHKAVLDVFEEG----- 369
            ||||......:|.|.:...|:.:.....|||..:   .|.|...::.....|.:.|.|||
  Fly   256 LPKFDTRSVLSLEDTVYDAGLTDLRNDFADLDKLLIAIGHRGACLTLYHQFARIVVDEEGLPNAV 320

Human   370 -TEASAATAVKITLLSALVETRTIVRFNRPFLMIIV 404
             .::|....:|.             ..||||..:::
  Fly   321 PQKSSGKNNIKF-------------HVNRPFAYLVL 343

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	76/361 (21%)
		RCL	369..394		3/30 (10%)
		O-glycosylated at one site	381..389		0/7 (0%)
Spn77Bb	NP_649206.1	serpin	13..358	CDD:476815	72/351 (21%)