Protein Alignment SERPINA3 and Spn28Dc

DIOPT Version :10

• Sequence 1: NP_001076.2
• Gene: SERPINA3 / 12
• HGNCID: 16
• Length: 423
• Species: Homo sapiens
• Sequence 2: NP_609172.1
• Gene: Spn28Dc / 34091
• FlyBaseID: FBgn0031973
• Length: 536
• Species: Drosophila melanogaster
• Alignment Length: 507
• Identity: 127/507 - (25%)
• Similarity: 213/507 - (42%)
• Gaps: 118/507 - (23%)

Human     5 LPLLALGLLAAGFCPAVLCHPNSPLDEENLTQENQDRGT--------------HVDLG----LAS 51
            :||.:.||:             :.|..:|....|:..||              :|||.    :|:
  Fly    59 VPLQSPGLV-------------NGLGNQNDPALNRISGTSVKPSNLPAAYSNGYVDLATSDRIAN 110

Human    52 ANVDFAFSLYKQLVLKAPDKNVIFSPLSISTALAFLSLGAHNTTLTEILKGLKFNLTETSEAEIH 116
            :.::||..|.:.|   |..|..|:|||||..:||.|.|||...:..|:  ...|::.:||  .:|
  Fly   111 SVLNFANILGQHL---ANGKTQIYSPLSIVHSLALLLLGAKGRSYEEL--STVFDIPDTS--RLH 168

Human   117 QSFQHLLRTLNQSSDEL----------------------------QLSMGNAMFVKEQLSLLDRF 153
            :.|..:|:.|.|.:.|.                            ::.:.|.:|.:...:|...:
  Fly   169 EQFGLMLQDLQQPTREAISAGRPLTDWRASSAMRSNRRAQRPGAHEVHLANGLFTQTGYTLNPDY 233

Human   154 TEDAKRLYGSEAFATDFQDS-AAAKKLINDYVKNGTRGKITDLI-KDLDSQTMMVLVNYIFFKAK 216
            ......:|.|:....||:.| |.|:..||.||...|:..|.::| .|:...|.|:|.|.::|||.
  Fly   234 RRVIVEVYASDLQIQDFEGSPATARYNINAYVAQHTKNHIENIIASDIPQTTRMILANALYFKAF 298

Human   217 WEMPFDPQDTHQSRFYLSKKKWVMVPMMSLHHL----TIPYFRDEELSCTVVELKYTGNASALFI 277
            ||..|....|....||.:.:.  ..|:|.:..:    ..||..|.||.|.::.|.|.||.|.::|
  Fly   299 WETDFIESATRPDNFYPNGEG--TEPVMRVQMMATGGAYPYHEDHELGCKIIGLPYRGNLSTMYI 361

Human   278 L-PDQDKMEEVEAMLLPETLKRWRDSLE------FREIGELYLPKFSISRDYNLNDILLQLGIEE 335
            : |.:..:.|:  |.|.:.|.  .|.:|      :|....:..||..::...||..::.::|:..
  Fly   362 IQPFKSSVREL--MALQKRLT--ADKIESMISRMYRRAALVAFPKMHLTESVNLKTVMQRMGLGG 422

Human   336 AFTS-KADLS---------------------------GITGAR-NLAVSQVVHKAVLDVFEEGTE 371
            .|:: :.|||                           |..||| :|.|..:|||....|.|:|||
  Fly   423 IFSAVQNDLSLIATNEATRTNALGGNSLQNLEAQRRAGTGGARSDLVVDDIVHKVDFTVNEQGTE 487

Human   372 ASAATAVKITLLSALVETRTIVRFNRPFLMIIVPTDTQNIFFMSKVTNPKQA 423
            |:|::...:......|    :.|.:.||::::....|:.:.|...:..|..|
  Fly   488 AAASSVTYLKKSGPDV----LFRGDTPFMVLVRHDPTKLVLFYGLINEPPAA 535

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
SERPINA3	NP_001076.2	serpinA3_A1AC	40..421	CDD:381019	118/468 (25%)
		RCL	369..394		6/24 (25%)
		O-glycosylated at one site	381..389		1/7 (14%)
Spn28Dc	NP_609172.1	serpin28D-like_insects	111..532	CDD:381061	112/437 (26%)