Protein Alignment Atp8a1 and CG33298

DIOPT Version :10

• Sequence 1: XP_017176112.1
• Gene: Atp8a1 / 11980
• MGIID: 1330848
• Length: 1177
• Species: Mus musculus
• Sequence 2: NP_995666.1
• Gene: CG33298 / 2768929
• FlyBaseID: FBgn0032120
• Length: 1517
• Species: Drosophila melanogaster
• Alignment Length: 1342
• Identity: 409/1342 - (30%)
• Similarity: 648/1342 - (48%)
• Gaps: 313/1342 - (23%)

Mouse     5 PSMAPGSSYSGRGRLTHNQGARK------------PPGYEK-------TDDVSEKTSLADQEEVR 50
            || ||.|:..|||   |::.|.:            ||.:::       |.|..|:.|      .|
  Fly   174 PS-APTSATGGRG---HSRQASRSESIYTLRRTEAPPWWKRLTLCNYNTGDKFEERS------YR 228

Mouse    51 TIFINQ---PQLTK-------FCNNHVSTAKYNVITFLPRFLYSQFRRAANSFFLFIALLQQIPD 105
            |:..|.   |:..|       |..|.:.|.||.:::|:|:.|..||.|.||.:|:||.||..:|:
  Fly   229 TVVPNHTVPPKTPKRDHPNGQFVGNKIRTTKYTLLSFIPKNLLEQFHRVANLYFIFIVLLNWVPE 293

Mouse   106 VSPTGRYTTLVPLLFILAVAAIKEIIEDIKRHKADNAVNKKQTQVL--RNGAWEIVHWEKVAVGE 168
            :|..|:...::|:||:|.|.|:|::.||.:|..:|..:|....:|.  ....::.|.|:::.||:
  Fly   294 ISAFGKEVAMIPVLFVLGVTAVKDLFEDRRRRASDKRINNTTCRVYDGETERYKKVKWQELRVGD 358

Mouse   169 IVKVTNGEHLPADLLSLSSSEPQAMCYIETSNLDGETNLKIRQGLPATSDIKDIDSLMRISGRIE 233
            ||.::|.|.:|||:|.|.:|:||.:|||:|.:||||||||.|:.:....:::.|....:...|:|
  Fly   359 IVHLSNNETVPADILLLRTSDPQGVCYIDTCDLDGETNLKRREVVRGFEEMQSIFVPSKFVSRVE 423

Mouse   234 CESPNRHLYDFVGNIRLDGHGTVPLGADQILLRGAQLRNTQWVHGIVVYTGHDTKLMQNSTSPPL 298
            .::|...||.|.|.:.......||:..:.:|||.::|:||.::.|||||.||:||.|.|::.|..
  Fly   424 ADAPTTKLYRFHGALIHPTGERVPISTECLLLRESRLKNTDYIEGIVVYAGHETKSMLNNSGPRY 488

Mouse   299 KLSNVERITNVQILILFCILIAMSLVCSVGSAIWNRRHSGKDWYLHLHYGGASNFGLN------F 357
            |.|.||:..|:.::....||:.:.:|.::|..:|....:    :..:.|...:....|      |
  Fly   489 KRSQVEQQMNIDVIWCVIILLILCVVGAIGCRMWLSSFT----HFPVPYLPPNKLTANMESMWIF 549

Mouse   358 LTFIILFNNLIPISLLVTLEVVKFTQAYFINWDLDMHYEPTDTAAMARTSNLNEELGQVKYIFSD 422
            .|:|::...:||:||.||:|:.|..|.:.|:.::|:....|:.....|..|:.|||||:::||:|
  Fly   550 WTYIVILQVMIPLSLYVTIELCKILQVFHIHNNVDLFDAETNKQTECRAMNITEELGQIQHIFTD 614

Mouse   423 KTGTLTCNVMQFKKCTIAGVAYGHVPEPEDYGCSPDEWQSSQFGDEKTFNDPS-----LL--DNL 480
            ||||||.|.|.|::|.:.|..|.|.|              |:.  ||.::.|.     |:  |||
  Fly   615 KTGTLTENKMIFRRCVVNGSDYNHPP--------------SEL--EKIYSKPGAPAPPLIPNDNL 663

Mouse   481 QNN----------HPTAPIICEFLTMMAVCHT----AVPERE----------------------- 508
            .::          .|.|..|.|||.::|:|:|    |.|.|:
  Fly   664 NSDMAQLTQGTYLTPHAQRIQEFLVVLAICNTVIVGAAPHRDMMNASGIIEVQQIGNSPANLKHG 728

Mouse   509 ----------------------------------------------------------------- 508
                                                                             
  Fly   729 KQRQKLLASSTSTTTTTTIINGPTTQPQVVSIPADRYIRLAESRSVTPSPPPNLLFALPAQSHQP 793

Mouse   509 -------------------------------------------GDKI------------------ 512
                                                       ..||
  Fly   794 TLSPISSSAESSPNSESESPSPPMKNKSLSNSISPTGRAKAVINSKITSIATFLNAKTQGKRMKL 858

Mouse   513 ----------------IYQAASPDEGALVRAAKQLNFVFTGRTPDSVIID--SLGQEERYELLNV 559
                            :|:|.||||.|||.||...:.....|:|:.:::.  ..|....||:|.|
  Fly   859 PSSKTGTIYRTADGRPLYEAESPDELALVNAAYSYDCCLLNRSPNQILVSMPMAGATREYEILKV 923

Mouse   560 LEFTSARKRMSVVVR-TPSGKLRLYCKGADTVIYERLAETSK------YKEITLKHLEQFATEGL 617
            |.|.|:||.||:||| ..|.::.||.||||:.|...|...|.      .:|.|.:.|:::|.|||
  Fly   924 LPFDSSRKCMSIVVRQIGSQEIVLYTKGADSSIMPVLVPCSHNSPEGILREQTQQLLDRYAREGL 988

Mouse   618 RTLCFAVAEISESDFEEWRAVYHRASTSVQNRLLKLEESYELIEKNLQLLGATAIEDKLQDQVPE 682
            |.|..|...::.:|:.:|.|.:.....|::||..:|.:|:..:|.||.|||||.|||:|||.|||
  Fly   989 RILVMAKRTLNSADYTDWWARHQEIEMSLENRERRLRDSFAKLESNLTLLGATGIEDRLQDGVPE 1053

Mouse   683 TIETLMKADIKIWILTGDKQETAINIGHSCRLLKRNMGMIVINEGSLDGTRETLSRHCTTL---- 743
            ||.:|:.|.|.:|:|||||.||||||.:|.:|..:.|.:|.:...|.|.....::.:.|.:
  Fly  1054 TIASLLSAGISVWVLTGDKPETAINIAYSAKLFTQQMELIRLTARSRDAAETAINFYLTDMENDK 1118

Mouse   744 -------GDALRKENDFALIIDGKTLKYALTFGVRQY--FLDLALSCKAVICCRVSPLQKSEVVE 799
                   |.:|||:.. ||::|||||.:.|....:..  ||.|:..|.:|:|||.:||||:.:|:
  Fly  1119 TTSTLGYGQSLRKKQR-ALVVDGKTLTFILDPKSKLILPFLRLSKRCASVLCCRSTPLQKAYLVK 1182

Mouse   800 MVKKQVKVITLAIGDGANDVSMIQTAHVGVGISGNEGLQAANSSDYSIAQFKYLKNLLMVHGAWN 864
            :||:::.:.|||||||||||||||.|.|||||||.||:||..::|:::.:|:||:.||:.||.|.
  Fly  1183 VVKEELNLRTLAIGDGANDVSMIQMADVGVGISGQEGMQAVMAADFTLPRFRYLERLLLAHGYWC 1247

Mouse   865 YNRVSKCILYCFYKNIVLYIIEIWFAFVNGFSGQILFERWCIGLYNVMFTAMPPLTLGIFERSCR 929
            |:|:|:.|||.||||.....:..|:....|||||::.::..:.|||::||::|||.:|::::...
  Fly  1248 YDRLSRMILYFFYKNAAFVFLIFWYQLYCGFSGQVMMDQMYLMLYNLIFTSLPPLAIGVYDKRVA 1312

Mouse   930 KENMLKYPELYKTSQNALDFNTKVFWVHCLNGLFHSVILFWFPLKALQYGTV----FGNGKTSDY 990
            ::.:||.|.|||..:..:.:....||:..|:.|:.|:::|:..|.|.....|    ||...|:.
  Fly  1313 EDLLLKNPYLYKNGRLGVAYRPHDFWLILLDALYQSLVIFFVALCAYAESDVGIWEFGTTITAS- 1376

Mouse   991 LLLGNFVYTFVVITVCLKAGLETSYWTWFSHIAIWGSIALWVVF-----------FGIYSSLWPA 1044
            .|..|.|:          ..:|...||....::|..|:..:.:|           ||:.||.|..
  Fly  1377 CLFANLVH----------CAIEIRSWTVLHVLSIVLSLGSFYLFAIVYDSVCMNCFGVRSSYWVI 1431

Mouse  1045 VPMAPDMSGEAAMLFSSGVFWVGLLSIPVASLLLDVLYKVIK 1086
            .           :.|:|.|.|:.::...|.::|..:|...::
  Fly  1432 F-----------VCFASAVHWLVIMLSTVVAVLPRLLLTTVR 1462

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Atp8a1	XP_017176112.1	ATPase-Plipid	62..1099	CDD:273734	388/1256 (31%)
CG33298	NP_995666.1	P-type_ATPase_APLT_Dnf-like	252..1355	CDD:319770	360/1123 (32%)