DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLK3 and Hipk

DIOPT Version :9

Sequence 1:	NP_001123500.2	Gene:	CLK3 / 1198	HGNCID:	2071	Length:	490	Species:	Homo sapiens
Sequence 2:	NP_001369036.1	Gene:	Hipk / 38070	FlyBaseID:	FBgn0035142	Length:	1409	Species:	Drosophila melanogaster

Alignment Length:	408	Identity:	121/408 - (29%)
Similarity:	201/408 - (49%)	Gaps:	64/408 - (15%)

- Green bases have known domain annotations that are detailed below.

Human    99 GPYRTRKHAHHCHKRRTR-SCSSASSRSQQSSKRSSRSVEDDKE--GHLVCRIGDWLQERYEIVG 160
            ||..:.|.||      |: :.|...:.:|..|||||...:.|.:  .|.|...   |...||::.
  Fly   141 GPISSLKTAH------TKVATSGGHANTQPPSKRSSSGADGDYQLVQHEVLYS---LSAEYEVLE 196

Human   161 NLGEGTFGKVVECLDHARGKSQ-VALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSD 224
            .||.||||:||:|  ..||.|: ||:||::|...|....::|:::|.::.:::.: :|..|...:
  Fly   197 FLGRGTFGQVVKC--WKRGTSEIVAIKILKNHPSYARQGQIEVSILSRLSQENAD-EFNFVRAFE 258

Human   225 WFNFHGHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLHENQLTHTDLKPENI 289
            .|....|.|:.||:|.:|.::|||:|.|.|.||.::|.:..|:..||..|.:..|.|.|||||||
  Fly   259 CFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILEQVLTALLKLKQLGLIHADLKPENI 323

Human   290 LFVNSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHT---TIVATRHYRPPEVILELGW 351
            :.|:...:..               .::|.|||||:  |...|   |.:.:|:||.||:||.|.:
  Fly   324 MLVDPVRQPY---------------RVKVIDFGSAS--HVSKTVCNTYLQSRYYRAPEIILGLPF 371

Human   352 AQPCDVWSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRK-QKYFYKG----G 411
            .:..|:||:||::.|.:.|:.|:......:.:..:.:..|....||::...| .|:||:.    .
  Fly   372 CEAIDMWSLGCVVAELFLGWPLYPGSSEFDQIRYISQTQGLPTEHMLNSASKTSKFFYRDVDSTY 436

Human   412 LVWDENSSDGRYVKENCKPLKS-----------------------YMLQDSLEHVQLFDLMRRML 453
            ..|...:::....:.|.|..::                       .:|.:..:..:..||::|||
  Fly   437 PFWRLKTTEEHEAETNTKSKEARKYIFNCLDDIGQVNVPTDLEGGQLLAEKTDRREFIDLLKRML 501

Human   454 EFDPAQRITLAEALLHPF 471
            ..|..:|:|.||||.|.|
  Fly   502 TIDQERRLTPAEALNHSF 519

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLK3	NP_001123500.2	PKc_CLK3	142..472	CDD:271116	107/362 (30%)
Hipk	NP_001369036.1	STKc_HIPK	192..520	CDD:271113	104/348 (30%)
Hipk	NP_001369036.1	PHA03378	<1080..1327	CDD:223065
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810