Protein Alignment CLK3 and mnb

DIOPT Version :9

• Sequence 1: NP_001123500.2
• Gene: CLK3 / 1198
• HGNCID: 2071
• Length: 490
• Species: Homo sapiens
• Sequence 2: NP_728107.2
• Gene: mnb / 32771
• FlyBaseID: FBgn0259168
• Length: 1047
• Species: Drosophila melanogaster
• Alignment Length: 466
• Identity: 137/466 - (29%)
• Similarity: 212/466 - (45%)
• Gaps: 90/466 - (19%)

Human    73 EERSPSFG-----ED-----------YYGPSRSRHRRRSRER----------GPYR--------T 103
            :..:|.:|     ||           :..||.|...|..:.|          ||.|        |
  Fly   182 QRHAPLYGRFVDAEDLPATHRDVMHHHSSPSSSSEVRAMQARIPNHFREPASGPLRKLSVDLIKT 246

Human   104 RKHAHHCH----KRRTRSCSSASSRSQQSSKRSSRSVEDDKEGHLVCRIGDWLQERYEIVGNLGE 164
            .||.:..:    |||.:........|.:..::......||.....:.:.|:...:||||...:|:
  Fly   247 YKHINEVYYAKKKRRAQQTQGDDDSSNKKERKLYNDGYDDDNHDYIIKNGEKFLDRYEIDSLIGK 311

Human   165 GTFGKVVECLDHARGKSQVALKIIRNVGKYREAARLEINVLKKIKEKDKENKFLCVLMSDWFNFH 229
            |:||:||:..||.. :..||:|||:|...:...|::|:.:|:.:...|.|||:..|.:...|.:.
  Fly   312 GSFGQVVKAYDHEE-QCHVAIKIIKNKKPFLNQAQIEVKLLEMMNRADAENKYYIVKLKRHFMWR 375

Human   230 GHMCIAFELLGKNTFEFLKENNFQPYPLPHVRHMAYQLCHALRFLH--ENQLTHTDLKPENILFV 292
            .|:|:.||||..|.::.|:..||:...|...|..|.|||.||.||.  |..:.|.||||||||..
  Fly   376 NHLCLVFELLSYNLYDLLRNTNFRGVSLNLTRKFAQQLCTALLFLSTPELNIIHCDLKPENILLC 440

Human   293 NSEFETLYNEHKSCEEKSVKNTSIRVADFGSATFDHEHHTTIVATRHYRPPEVILELGWAQPCDV 357
            |.                 |.::|::.||||:....:.....:.:|.||.|||:|.:.:....|:
  Fly   441 NP-----------------KRSAIKIVDFGSSCQLGQRIYHYIQSRFYRSPEVLLGIQYDLAIDM 488

Human   358 WSIGCILFEYYRGFTLFQTHENREHLVMMEKILGPIPSHMIHRTRKQKYFYKGGLVWDENSSDGR 422
            ||:||||.|.:.|..||......:.:..:.::||..|.:::.:..|.:.|:      |:..:||.
  Fly   489 WSLGCILVEMHTGEPLFSGCNEVDQMNKIVEVLGMPPKYLLDQAHKTRKFF------DKIVADGS 547

Human   423 YV-KEN-----CKPLKSYMLQDSL--------------------EHVQLFDLMRRMLEFDPAQRI 461
            || |:|     .||..|..|.|.|                    ::::..||:.|||:|||..|:
  Fly   548 YVLKKNQNGRKYKPPGSRKLHDILGVETGGPGGRRLDEPGHSVSDYLKFKDLILRMLDFDPKTRV 612

Human   462 TLAEALLHPFF 472
            |...||.|.||
  Fly   613 TPYYALQHNFF 623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CLK3	NP_001123500.2	PKc_CLK3	142..472	CDD:271116	114/357 (32%)
mnb	NP_728107.2	PKc_DYRK1	289..628	CDD:271128	116/359 (32%)
		S_TKc	303..623	CDD:214567	112/343 (33%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165155020
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740