DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp7b and ATP7

DIOPT Version :9

Sequence 1:	XP_006509070.1	Gene:	Atp7b / 11979	MGIID:	103297	Length:	1511	Species:	Mus musculus
Sequence 2:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1337	Identity:	570/1337 - (42%)
Similarity:	766/1337 - (57%)	Gaps:	232/1337 - (17%)

- Green bases have known domain annotations that are detailed below.

Mouse   198 PAQEAV------VKLRVEGMTCQSCVSSIEGKIRKLQGVVRIKVSLSNQEAVITYQPYLIQPEDL 256
            |:.|.|      |:|.:.||||||||.:|...|.:..|::.::|.|........|.|....|..:
  Fly     2 PSDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARI 66

Mouse   257 RDHICDMGFEAAIKNRTAPLRLGPIDVNKLESTNLKKETVSPVQISNHFETLGHQGSYLATLPLR 321
            ...|.|||||.:.....|    .|.:......||                             :|
  Fly    67 ASDIDDMGFECSYPGDAA----DPPETPASAWTN-----------------------------IR 98

Mouse   322 IDGMHCKSCVLNIEGNIGQLPGVQNIHVSLENKTAQIQYDPSCVTPMFLQTAIEALPPGHFKVSL 386
            :.||.|:|||.|||||||..||:.:|.|.|..|.|::||||:
  Fly    99 VVGMTCQSCVRNIEGNIGTKPGIHSIEVQLAAKNARVQYDPA----------------------- 140

Mouse   387 PDGVEENEPQSGSSQRHQEQGPGRTAVLTISGITCASSVQPIEDMLSQRKGVQQTSISLAEGTGA 451

  Fly   141 ----------------------------------------------------------------- 140

Mouse   452 VLYDPSIVSLDELRTAVEDMGFEVSVNSETFTINPVRNFKSGNSVPQTMGDIAGSVQKMAPDTRG 516
             .|||:     ::...::|||||.||..                 |::...........:|..|.
  Fly   141 -QYDPA-----QIAELIDDMGFEASVQE-----------------PRSPSQSPSPAPASSPKKRA 182

Mouse   517 LPTHQGPGHSSETPSSPGATASQ----KCFVQIKGMTCASCVSNIERSLQRHAGILSVLVALMSG 577
            .||...|.: ::..|:......|    |||:.|:||||||||:.||:..::..|:.|:||||::.
  Fly   183 TPTPPPPSY-AQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVALLAA 246

Mouse   578 KAEVKYDPEIIQSPRIAQLIQDLGFEASVMEDNTVSEGDIELIITGMTCASCVHNIESKLTRTNG 642
            |||||::..::.:..||:.|.:|||...::::....|.::||.|.||||||||:.|||.:.:..|
  Fly   247 KAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVLKIRG 311

Mouse   643 ITYASVALATSKAHVKFDPEIVGPRDIIKIIEEIGFHASL-AQRNPNAH-HLDHKTEIKQWKKSF 705
            :|.|||.|.|.:...::..|..|||.|.:.||.:||.|.| ..|:..|| :|:||.||::|:.:|
  Fly   312 VTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKWRNAF 376

Mouse   706 LCSLVFGIPVMGLMVYMLIPSSTPQETMVLDHNIIPGLSVLNLIFFILCTFVQFLGGWYFYVQAY 770
            |.||:||.|.|..|:|.::..|......:.  .::||||:.||:.|:|.|.|||.||::||||:|
  Fly   377 LVSLIFGGPCMVAMIYFMLEMSDKGHANMC--CLVPGLSMENLVMFLLSTPVQFFGGFHFYVQSY 439

Mouse   771 KSLRHRSANMDVLIVLATTIAYAYSLVILVVAVAEKAEKSPVTFFDTPPMLFVFIALGRWLEHVA 835
            ::::|.:.||||||.:.|||:|.||:.:::.||..:...||:|||||||||.:||:|||||||:|
  Fly   440 RAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTFFDTPPMLLIFISLGRWLEHIA 504

Mouse   836 KSKTSEALAKLMSLQATEATVVTLGEDNLILREEQVPMELVQRGDVIKVVPGGKFPVDGKVLEGN 900
            |.||||||:||:||:|.:|.:|.:..|..|:.|:.:.::.|||||::||:||.|.|||||||.|:
  Fly   505 KGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRGDILKVIPGAKVPVDGKVLYGH 569

Mouse   901 TMADESLITGEAMPVTKKPGSIVIAGSINAHGSVLLKATHVGNDTTLAQIVKLVEEAQMSKAPIQ 965
            :..||||||||:|||.|:.||:||.||||.:|.:|::|||.|.:|||||||:||||||.||||||
  Fly   570 SSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGENTTLAQIVRLVEEAQTSKAPIQ 634

Mouse   966 QLADRFSGYFVPFIIIISTLTLVVWIVIGFVDFGVVQKYFPSPSKHISQTEVIIRFAFQTSITVL 1030
            |||||.:||||||::::|::||:.||:|||.:..:|.... ....|:.|..:|:.:||:.:::||
  Fly   635 QLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAM-EHKMHMDQNTIIVSYAFKCALSVL 698

Mouse  1031 CIACPCSLGLATPTAVMVGTGVAAQNGVLIKGGKPLEMAHKIKTVMFDKTGTITHGVPRVMRFLL 1095
            .|||||:|||||||||||.||..|.||||:||...||.|||:|||:||||||||||.|...:..|
  Fly   699 AIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKTVVFDKTGTITHGTPMTSKVTL 763

Mouse  1096 LADVATLPLRKVLAVVGTAEASSEHPLGVAVTKYCKEELG------TETLGYSTDFQAVPGCGIS 1154
            ........|.:.|.:||.||.:||||:..|:..:.|:.|.      ..:.|.|:.|||||||||.
  Fly   764 FVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGATPQAGSFGKSSHFQAVPGCGIR 828

Mouse  1155 CKVSNVEGILARS----------DL-TAHPVGVGNPPTGEGAG-----PQ--------------- 1188
            ..|||.|..|.::          :| ..||  .|:.|...||.     ||
  Fly   829 VTVSNYEQTLRQACNADRIINYENLHRTHP--QGSVPVDNGASIEHLLPQRSVRKSMELNNQQLL 891

Mouse  1189 ---------------------TFSVLIGNREWMRRNGLTISSDISDAMTDHEMKGQTAILVAIDG 1232
                                 ...|||||||||.||.:.:..:|||.||..|.||.||:|.|::|
  Fly   892 SDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLEISDCMTHEERKGHTAVLCALNG 956

Mouse  1233 VLCGMIAIADAVKPEAALAIYTLKSMGVDVALITGDNRKTARAIATQVGINKVFAEVLPSHKVAK 1297
            .|..|.|::|.|||||.||:||||.||:||.|:||||:.||.:||.:|||..|:|||||||||||
  Fly   957 QLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAASIAREVGIRTVYAEVLPSHKVAK 1021

Mouse  1298 VQELQNEGKKVAMVGDGVNDSPALAQADVGIAIGTGTDVAIEAADVVLIRNDLLDVVASIHLSKR 1362
            :|.:|..|.:|||||||||||||||||||||.|..|||||.||:|:||:|||||||||.:.||:.
  Fly  1022 IQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEASDIVLMRNDLLDVVACLDLSRC 1086

Mouse  1363 TVRRIRVNLVLALIYNMVGIPIAAGVFMPIGIVLQPWMGSAAMAASSVSVVLSSLQLKCYRKPDL 1427
            ||||||.|...|.:||::|||:|:|:|.|.|..|.|||.|.||||||||||.|||.||.||||..
  Fly  1087 TVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAMAASSVSVVCSSLLLKMYRKPTA 1151

Mouse  1428 E-----RYEAQ-----AHGRMKPLSASQVSVHIGMDD 1454
            :     .||||     |.|....|  .::|:|.|:||
  Fly  1152 KTLRTAEYEAQLAAERASGSEDEL--DKLSLHRGLDD 1186

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Atp7b	XP_006509070.1	HMA	120..183	CDD:238219
		HMA	205..268	CDD:238219	23/62 (37%)
		HMA	320..377	CDD:238219	25/56 (45%)
		HMA	413..476	CDD:238219	8/62 (13%)
		HMA	543..605	CDD:238219	28/61 (46%)
		HMA	618..681	CDD:238219	30/62 (48%)
		P-type_ATPase_Cu-like	703..1400	CDD:319783	389/754 (52%)
ATP7	NP_001259466.1	HMA	16..78	CDD:238219	23/61 (38%)
		HMA	97..159	CDD:238219	33/155 (21%)
		HMA	214..274	CDD:238219	28/59 (47%)
		ZntA	285..1131	CDD:225127	435/850 (51%)
		HMA	287..350	CDD:238219	30/62 (48%)
		E1-E2_ATPase	489..735	CDD:278548	144/246 (59%)
		COG4087	<984..1085	CDD:226572	71/100 (71%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167835954
Domainoid	1	1.000	239	1.000	Domainoid score	I2267
eggNOG	1	0.900	-	-		E1_COG2217
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	1007	1.000	Inparanoid score	I290
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53773
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001874
OrthoInspector	1	1.000	-	-		otm43975
orthoMCL	1	0.900	-	-		OOG6_100289
Panther	1	1.100	-	-	LDO	PTHR43520
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R123
SonicParanoid	1	1.000	-	-		X1231
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790