back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Atp7a and ATP7

DIOPT Version :9

Sequence 1:	NP_001103227.1	Gene:	Atp7a / 11977	MGIID:	99400	Length:	1492	Species:	Mus musculus
Sequence 2:	NP_001259466.1	Gene:	ATP7 / 32142	FlyBaseID:	FBgn0030343	Length:	1254	Species:	Drosophila melanogaster

Alignment Length:	1296	Identity:	578/1296 - (44%)
Similarity:	791/1296 - (61%)	Gaps:	123/1296 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse   274 PSD-------STTMFTIEGMHCKSCVSNIESALSTLQYVSSIVVSLENRSAIVKYNASLVTPEML 331
            |||       ||....|.||.|:|||.||...:.....:..:.|.||..:....|:.....|..:
  Fly     2 PSDERVEATMSTVRLPIVGMTCQSCVRNITEHIGQKSGILGVRVILEENAGYFDYDPRQTDPARI 66

Mouse   332 RKAIEAISPGQYRVSIASEVESTASSPSSSSLQKMPLNIVSQPLTQEAVININGMTCNSCVQSIE 396
            ...|:.:.   :..|...:......:|:|:...                |.:.||||.|||::||
  Fly    67 ASDIDDMG---FECSYPGDAADPPETPASAWTN----------------IRVVGMTCQSCVRNIE 112

Mouse   397 GVISKKPGVKSIHVSLANSTGTIEFDPLLTSPETLREAIEDMGFDAAL-----PADMKEPLVVIA 456
            |.|..|||:.||.|.||.....:::||....|..:.|.|:||||:|::     |:....|....:
  Fly   113 GNIGTKPGIHSIEVQLAAKNARVQYDPAQYDPAQIAELIDDMGFEASVQEPRSPSQSPSPAPASS 177

Mouse   457 QPSLETPLLPSSNELEN-------VMTSVQNKCYIQVSGMTCASCVANIERNLRREEGIYSVLVA 514
            .....||..|..:..:|       |...:..||::.:.|||||||||.||::.::..|:.|:|||
  Fly   178 PKKRATPTPPPPSYAQNGSAVAIPVEQELLTKCFLHIRGMTCASCVAAIEKHCKKIYGLDSILVA 242

Mouse   515 LMAGKAEVRYNPAVIQPRVIAEFIRELGFGAMVMENAGEGNGILELVVRGMTCASCVHKIESTLT 579
            |:|.||||::|..|:....||:.|.||||...:::....|...:||.:.||||||||:||||.:.
  Fly   243 LLAAKAEVKFNANVVTAENIAKSITELGFPTELIDEPDNGEAEVELEIMGMTCASCVNKIESHVL 307

Mouse   580 KHKGIFYCSVALATNKAHIKYDPEIIGPRDIIHTIGSLGFEASLVK-KDRSA-NHLDHKREIKQW 642
            |.:|:...||.|.|.:...:|..|..|||.|...|.:|||||.|:. :|:.| |:|:||.||::|
  Fly   308 KIRGVTTASVTLLTKRGKFRYITEETGPRSICEAIEALGFEAKLMTGRDKMAHNYLEHKEEIRKW 372

Mouse   643 RGSFLVSLFFCIPVMGLMVYMMVMDHHLATLHHNQNMSNEEMINMHSAMFLERQILPGLSIMNLL 707
            |.:|||||.|..|.|..|:|.|:            .||::...||..       ::||||:.||:
  Fly   373 RNAFLVSLIFGGPCMVAMIYFML------------EMSDKGHANMCC-------LVPGLSMENLV 418

Mouse   708 SLLLCLPVQFCGGWYFYIQAYKALKHKTANMDVLIVLATTIAFAYSLVILLVAMFERAKVNPITF 772
            ..||..||||.||::||:|:|:|:||.|.||||||.:.|||::.||:.:::.|:......:|:||
  Fly   419 MFLLSTPVQFFGGFHFYVQSYRAIKHGTTNMDVLISMVTTISYVYSVAVVIAAVLLEQNSSPLTF 483

Mouse   773 FDTPPMLFVFIALGRWLEHIAKGKTSEALAKLISLQATEATIVTLNSENLLLSEEQVDVELVQRG 837
            |||||||.:||:|||||||||||||||||:||:||:|.:|.:|.::.:..::||:.:.|:.||||
  Fly   484 FDTPPMLLIFISLGRWLEHIAKGKTSEALSKLLSLKAADALLVEISPDFDIISEKVISVDYVQRG 548

Mouse   838 DIIKVVPGGKFPVDGRVIEGHSMVDESLITGEAMPVAKKPGSTVIAGSINQNGSLLIRATHVGAD 902
            ||:||:||.|.||||:|:.|||..||||||||:|||||:.||.||.|||||||.||:.|||.|.:
  Fly   549 DILKVIPGAKVPVDGKVLYGHSSCDESLITGESMPVAKRKGSVVIGGSINQNGVLLVEATHTGEN 613

Mouse   903 TTLSQIVKLVEEAQTSKAPIQQFADKLSGYFVPFIVLVSIVTLLVWIIIGFQNFEIVETYFPGYN 967
            |||:|||:||||||||||||||.||:::||||||:|:||.:||:.||||||.|..:|..... :.
  Fly   614 TTLAQIVRLVEEAQTSKAPIQQLADRIAGYFVPFVVVVSSITLIAWIIIGFSNPNLVPVAME-HK 677

Mouse   968 RSISRTETIIRFAFQASITVLCIACPCSLGLATPTAVMVGTGVGAQNGILIKGGEPLEMAHKVKV 1032
            ..:.:...|:.:||:.:::||.|||||:|||||||||||.||.||.||:|:||...||.|||||.
  Fly   678 MHMDQNTIIVSYAFKCALSVLAIACPCALGLATPTAVMVATGTGAINGVLVKGATALENAHKVKT 742

Mouse  1033 VVFDKTGTITHGTPVVNQVKVLVESNKISRNKILAIVGTAESNSEHPLGAAVTKYCKKELD---- 1093
            ||||||||||||||:.::|.:.|.:...|..:.|.|||.||.|||||:.:|:..:.|..|:
  Fly   743 VVFDKTGTITHGTPMTSKVTLFVTAQVCSLARALTIVGAAEQNSEHPIASAIVHFAKDMLNVGAT 807

Mouse  1094 --TETLGTCTDFQVVPGCGISCKVTNIEGL---------------LHKSNLKIEENNIKNASLVQ 1141
              ..:.|..:.||.||||||...|:|.|..               ||:::   .:.::...:...
  Fly   808 PQAGSFGKSSHFQAVPGCGIRVTVSNYEQTLRQACNADRIINYENLHRTH---PQGSVPVDNGAS 869

Mouse  1142 IDAINEQSSTSSSMIIDAH--LSNAV--------------NTQQYKVLIGNREWMIRNGLVISND 1190
            |:.:..|.|...||.::..  ||:.|              ::.:..|||||||||.||.:.:..:
  Fly   870 IEHLLPQRSVRKSMELNNQQLLSDLVLEPEEELLTDQKIIDSPEILVLIGNREWMERNAIEVPLE 934

Mouse  1191 VDESMIEHERRGRTAVLVTIDDELCGLIAIADTVKPEAELAVHILKSMGLEVVLMTGDNSKTARS 1255
            :.:.|...||:|.||||..::.:|..:.|::|.|||||.|||:.||.||::|||:||||..||.|
  Fly   935 ISDCMTHEERKGHTAVLCALNGQLVCMFAVSDMVKPEAHLAVYTLKRMGIDVVLLTGDNKNTAAS 999

Mouse  1256 IASQVGITKVFAEVLPSHKVAKVKQLQEEGKRVAMVGDGINDSPALAMANVGIAIGTGTDVAIEA 1320
            ||.:|||..|:|||||||||||::::|..|.||||||||:|||||||.|:|||.|..|||||.||
  Fly  1000 IAREVGIRTVYAEVLPSHKVAKIQRIQANGIRVAMVGDGVNDSPALAQADVGITIAAGTDVAAEA 1064

Mouse  1321 ADVVLIRNDLLDVVASIDLSRKTVKRIRINFVFALIYNLVGIPIAAGVFLPIGLVLQPWMGSAAM 1385
            :|:||:|||||||||.:||||.||:|||.||.||.:|||:|||:|:|:|.|.|..|.|||.|.||
  Fly  1065 SDIVLMRNDLLDVVACLDLSRCTVRRIRYNFFFASMYNLLGIPLASGLFAPYGFTLLPWMASVAM 1129

Mouse  1386 AASSVSVVLSSLFLKLYRKPTYD-----NYELHPRSHTGQRSPSE---ISVHVGIDDT------- 1435
            ||||||||.|||.||:|||||..     .||....:.....|..|   :|:|.|:||.
  Fly  1130 AASSVSVVCSSLLLKMYRKPTAKTLRTAEYEAQLAAERASGSEDELDKLSLHRGLDDLPEKGRMP 1194

Mouse  1436 -SRNSPRLGLLDRIVNYSRASINSLLSDKRSLNSVVTSEPD---KHSLLVGDFREDDDTTL 1492
             .|:|  ..|:.||..:...:|.|  .|.:....::..|..   :..::...|..:|.|.|
  Fly  1195 FKRSS--TSLISRIFMHDYGNITS--PDAKYGEGLLDPEEQYDGRTKIVRSRFHANDSTEL 1251

Known Domains:

Indicated by green bases in alignment.

Software error:

Illegal division by zero at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 591.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.