DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLK2 and Dyrk2

DIOPT Version :9

Sequence 1:	NP_001281267.1	Gene:	CLK2 / 1196	HGNCID:	2069	Length:	499	Species:	Homo sapiens
Sequence 2:	NP_001260456.1	Gene:	Dyrk2 / 34831	FlyBaseID:	FBgn0016930	Length:	757	Species:	Drosophila melanogaster

Alignment Length:	365	Identity:	116/365 - (31%)
Similarity:	199/365 - (54%)	Gaps:	42/365 - (11%)

- Green bases have known domain annotations that are detailed below.

Human   128 FSRSSSQHSSRRAKSVE------DDAEGH--LIYHVGDWLQERYEIVSTLGEGTFGRVVQCVDHR 184
            |.:.:|::.::.|.:..      ||..|:  :|.|  |.:..||||:..:|:|:||:|::.:||:
  Fly   192 FGQHASKNYNKPAPTANTTNLGYDDDNGNYKIIEH--DHIAFRYEILEVIGKGSFGQVIRALDHK 254

Human   185 RGGARVALKIIKNVEKYKEAARLEINVLEKINEKDPDNKNLCVQMFDWFDYHGHMCISFELLGLS 249
            . ...||:|||:|.:::...|.:|:|:|:::.|||.|..:..:.|.|:..:..|:||:|||:.|:
  Fly   255 T-NTHVAIKIIRNKKRFLNQAVVELNILDELREKDADGSHNVIHMLDYTYFRKHLCITFELMSLN 318

Human   250 TFDFLKDNNYLPYPIHQVRHMAFQLCQAVKFLHDNKLTHTDLKPENILFVNSDYELTYNLEKKRD 314
            .::.:|.|||..:.:..:|.....:.:.::.|:...:.|.||||||||.            |:|.
  Fly   319 LYELIKKNNYNGFSMSLIRRFCNSIVKCLRLLYKENIIHCDLKPENILL------------KQRG 371

Human   315 ERSVKSTAVRVVDFGSATFDHEHHSTIVSTRHYRAPEVILELGWSQPCDVWSIGCIIFEYYVGFT 379
                 |::::|:||||:.:......|.:.:|.||:|||||.|.:....|:||:|||:.|.|.||.
  Fly   372 -----SSSIKVIDFGSSCYVDRKIYTYIQSRFYRSPEVILGLQYGTAIDMWSLGCILAELYTGFP 431

Human   380 LFQTHDNREHLAMMERILGPIPSRMIRKTRKQKYFYRGRLDWDENTSAGRYVRENCKPLRRYLTS 444
            ||...:..|.||.:..:||..|..:|...|:::.|:..|       .|.|.: .|.|..:|...|
  Fly   432 LFPGENEVEQLACIMEVLGLPPKVLISVARRRRLFFDSR-------DAPRCI-TNTKGRKRSPGS 488

Human   445 EAEEH------HQLFDLIESMLEYEPAKRLTLGEALQHPF 478
            ::..|      ....|.::..||::||:|:|..||..|.|
  Fly   489 KSLAHILHCQDRYFIDFLQRCLEWDPAERMTPDEAAHHEF 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLK2	NP_001281267.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..67
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	101..143		3/14 (21%)
		PKc_CLK2	150..479	CDD:271117	110/337 (33%)
Dyrk2	NP_001260456.1	PKc_DYRK4	186..529	CDD:271127	116/365 (32%)
Dyrk2	NP_001260456.1	S_TKc	233..529	CDD:214567	106/322 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810