DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CLK1 and lkh1

DIOPT Version :9

Sequence 1:	NP_001155879.1	Gene:	CLK1 / 1195	HGNCID:	2068	Length:	526	Species:	Homo sapiens
Sequence 2:	NP_001018187.2	Gene:	lkh1 / 3361532	PomBaseID:	SPAC1D4.11c	Length:	690	Species:	Schizosaccharomyces pombe

Alignment Length:	385	Identity:	154/385 - (40%)
Similarity:	239/385 - (62%)	Gaps:	23/385 - (5%)

- Green bases have known domain annotations that are detailed below.

Human   145 KSSGRSGRSSYKSKHR-----IHHSTSHRRSHGKSHRRKRTRSVEDDEEGHLICQSGDVLSARYE 204
            |...|:....||...|     :|.:|:.            ..|..||::||.........:.||.
pombe   311 KKRKRAAWPPYKKVDRVNVPVVHDTTAF------------DPSTFDDDDGHYKVVPNSKFANRYT 363

Human   205 IVDTLGEGAFGKVVECIDHKAGGRHVAVKIVKNVDRYCEAARSEIQVLEHLNTTDPNSTFRCVQM 269
            :|..||.|.||||::|.| ::.|||.|:|:.:.:.:|.||:..|::||:.:..:||.:..:|:|:
pombe   364 VVRLLGHGTFGKVIQCYD-QSTGRHCAIKVTRAIPKYREASLIELRVLQTIAHSDPTNENKCIQL 427

Human   270 LEWFEHHGHICIVFELLGLSTYDFIKENGFLPFRLDHIRKMAYQICKSVNFLHSNKLTHTDLKPE 334
            .::|::..|||||.:|.|.|.:||:|.|.::||.|.||:.::.|:.|||.||||..|.|||||||
pombe   428 RDYFDYRKHICIVTDLFGWSVFDFLKNNNYIPFPLKHIQMLSQQLFKSVAFLHSLGLVHTDLKPE 492

Human   335 NILFVQSDYTEAYNPKIKRDERTLINPDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWS 399
            |:|.|.:.......|.....::.|.:.:|:::||||||::||:||::||||||||||:||.||||
pombe   493 NVLLVSNASRTIRLPYRNYSQKVLNSCEIRLIDFGSATFEDEYHSSVVSTRHYRAPEIILGLGWS 557

Human   400 QPCDVWSIGCILIEYYLGFTVFPTHDSKEHLAMMERILGPLPKHMIQKTRK--RKYFHHD-RLDW 461
            .|||||||||||:|.:.|..:|.||:..|||.|||:||||..::||.::.:  :::|..| ::.:
pombe   558 YPCDVWSIGCILVELFTGQALFQTHEDSEHLCMMEKILGPFDRNMISRSSRTSQRFFKSDGKVRY 622

Human   462 DEHSSAGRYVS--RRCKPLKEFMLSQDVEHERLFDLIQKMLEYDPAKRITLREALKHPFF 519
            ...::..:.::  :..:.|::.......|...|.||::|:..|||.:|||.:|||.||||
pombe   623 PLSNTPKKSINYLQSLQTLEQIFAVSSPEVALLLDLLKKVFVYDPKRRITAKEALWHPFF 682

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CLK1	NP_001155879.1	PKc_CLK1_4	190..519	CDD:271115	141/333 (42%)
CLK1	NP_001155879.1	S_TKc	203..519	CDD:214567	139/320 (43%)
lkh1	NP_001018187.2	E_Pc_C	<104..198	CDD:284226
		PKc_CLK	349..682	CDD:271036	141/333 (42%)
		S_TKc	362..682	CDD:214567	139/320 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	297	1.000	Domainoid score	I301
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000672
OrthoInspector	1	1.000	-	-		otm53799
orthoMCL	1	0.900	-	-		OOG6_100708
Panther	1	1.100	-	-	O	PTHR45646
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R660
SonicParanoid	1	1.000	-	-		X440
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.800